{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:48:44Z","timestamp":1777290524381,"version":"3.51.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":91,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in \u201clikely molar pregnancy\u201d in the second trimester. Subsequent ultrasound confirmed a cystic appearing portion of the placenta. At 22 weeks, the patient delivered a demised fetus and two placentas. Pathology was consistent with CHMCF. This case is the first to show primary detection of a CHMCF with single-nucleotide polymorphism (SNP)-based NIPT prior to ultrasound identification. Our case suggests the use of SNP-based NIPT as an alternative noninvasive method to guide shared decision-making and clinical management for patients with this diagnosis.<\/jats:p>","DOI":"10.1055\/s-0043-1774727","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T22:33:23Z","timestamp":1696113203000},"page":"e49-e52","source":"Crossref","is-referenced-by-count":3,"title":["Complete Hydatidiform Mole with a Coexisting Viable Male Fetus Detected by Cell-Free DNA"],"prefix":"10.1055","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-8668","authenticated-orcid":false,"given":"Mackenzie","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Kus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kali","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9757","authenticated-orcid":false,"given":"Mai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Bligard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Lawlor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"issue":"03","key":"ref1","first-page":"147","article-title":"Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses","volume":"39","author":"M A Steller","year":"1994","journal-title":"J Reprod Med"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/uog.14854","article-title":"Detection of complete molar pregnancy by single-nucleotide polymorphism-based non-invasive prenatal testing","volume":"46","author":"A L Simon","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1055\/s-0040-1709981","article-title":"Cell-free DNA as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: a case report","volume":"10","author":"M G Gabra","year":"2020","journal-title":"AJP Rep"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000136099.21216.45","article-title":"Low risk of relapse after achieving undetectable HCG levels in women with complete molar pregnancy","volume":"104","author":"A J Wolfberg","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"71","key":"ref5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.15557\/JoU.2017.0044","article-title":"A twin pregnancy with a hydatidiform mole and a coexisting live fetus: prenatal diagnosis, treatment, and follow-up","volume":"17","author":"A Braga","year":"2017","journal-title":"J Ultrason"},{"key":"ref6","volume-title":"Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice","author":"R K Creasy","year":"2009","edition":"6th ed."},{"key":"ref7","first-page":"113","article-title":"Twin pregnancy; hydatidiform mole associated with normal ovum; abortion at four months","volume":"7","author":"G Luker","year":"1914","journal-title":"Proc R Soc Med"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/1471-0528.16283","article-title":"Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta-analysis","volume":"127","author":"N Zilberman Sharon","year":"2020","journal-title":"BJOG"},{"issue":"01","key":"ref9","first-page":"e96","article-title":"Complete molar pregnancies with a coexisting fetus: pregnancy outcomes and review of literature","volume":"12","author":"R A Irani","year":"2021","journal-title":"AJP Rep"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"79.e1","DOI":"10.1016\/j.ajog.2014.10.012","article-title":"Detection of triploid, molar, and vanishing twin pregnancies by a single-nucleotide polymorphism-based noninvasive prenatal test","volume":"212","author":"K J Curnow","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/pd.6169","article-title":"Non-invasive prenatal screening for fetal triploidy using single nucleotide polymorphism-based testing: differential diagnosis and clinical management in cases showing an extra haplotype","volume":"42","author":"V Kantor","year":"2022","journal-title":"Prenat Diagn"},{"issue":"05","key":"ref12","first-page":"241","article-title":"Epidemiological report on the treatment of patients with gestational trophoblastic disease in 10 Brazilian referral centers: results after 12 years since International FIGO 2000 Consensus","volume":"59","author":"A Braga","year":"2014","journal-title":"J Reprod Med"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/uog.7666","article-title":"Chorionic villus sampling in the prenatal diagnosis of placental mesenchymal dysplasia","volume":"36","author":"M Arigita","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/humrep\/deh211","article-title":"Prenatal diagnosis of a complete mole coexisting with a dichorionic twin pregnancy: case report","volume":"19","author":"L Bovicelli","year":"2004","journal-title":"Hum Reprod"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1774727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T22:33:30Z","timestamp":1696113210000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1774727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":14,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,7,14]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1774727","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}