{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:22:03Z","timestamp":1791915723476,"version":"4.3.4"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Some psychological and personality characteristics of individuals seem to determine behavioral patterns that are associated with better health throughout life and, consequently, prevent the progression of early cognitive changes to dementia.<\/jats:p><jats:p>\n          Objective\u2003To identify which individuals have modified cognitive ratings after 24 months of follow-up and correlating with personality traits.<\/jats:p><jats:p>\n          Methods\u2003One hundred and two volunteers were evaluated clinically and for personality characteristics and neuropsychological testing. Of these, 25 subjects were classified as cognitively normal (CN), 25 as subjective cognitive decline (SCD), 28 as nonamnestic mild cognitive impairment (naMCI), and 24 as amnestic mild cognitive impairment (amMCI) at baseline. Follow-up occurred over 2 years from the initial assessment, and the cognitive categories of the participants were re-analyzed every 6 months to observe differences in their classification.<\/jats:p><jats:p>\n          Results\u2003Out of the 102 subjects, 65 remained at follow-up. The sample followed-up longitudinally was composed predominantly of women (65%), white (74%), with a mean age of 78 (\u00b17.5) years old and 12 (\u00b14.8) years of schooling. Throughout the process, 23% of CN, 15% of SDC, and 27% of naMCI individuals worsened cognitively. Amnestic with mild cognitive impairment volunteers remained stable or improved. Individuals with older age show more significant cognitive deterioration, and those with very low or high rates of the openness personality trait are associated with cognitive decline utilizing the Fisher exact test, probably because the open extremes influence choices, stress management, and behavioral maintenance.<\/jats:p><jats:p>\n          Conclusion\u2003The factors most associated with cognitive change in this group of older adults were age and the intensity of the openness aspects of personality.<\/jats:p>","DOI":"10.1055\/s-0043-1775884","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T23:37:35Z","timestamp":1698622655000},"page":"868-875","source":"Crossref","is-referenced-by-count":10,"title":["Openness and age influence cognitive progression: a longitudinal study"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-4687","authenticated-orcid":false,"given":"Silvia Stahl","family":"Merlin","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Departamento de Neurologia, Unidade de Neurologia Cognitiva e Comportamental, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6732","authenticated-orcid":false,"given":"Sonia Maria Dozzi","family":"Brucki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Departamento de Neurologia, Unidade de Neurologia Cognitiva e Comportamental, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/brainsci7090111","article-title":"Problems in Classifying Mild Cognitive Impairment (MCI): One or Multiple Syndromes?","volume":"7","author":"M DC D\u00edaz-Mardomingo","year":"2017","journal-title":"Brain Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.brainresbull.2009.07.004","article-title":"The impact of personality characteristics on the clinical expression in neurodegenerative disorders\u2013a review","volume":"80","author":"A von Gunten","year":"2009","journal-title":"Brain Res Bull"},{"issue":"19","key":"ref3","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1212\/WNL.0000000000002100","article-title":"Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging","volume":"85","author":"D S Knopman","year":"2015","journal-title":"Neurology"},{"issue":"01","key":"ref4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jagp.2015.06.001","article-title":"Trajectories of Neuropsychiatric Symptoms and Cognitive Decline in Mild Cognitive Impairment","volume":"24","author":"N D David","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"issue":"06","key":"ref5","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/01.psy.0000190615.20656.83","article-title":"Neuroticism, extraversion, and mortality in a defined population of older persons","volume":"67","author":"R S Wilson","year":"2005","journal-title":"Psychosom Med"},{"issue":"10","key":"ref6","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1001\/archpsyc.64.10.1204","article-title":"Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment","volume":"64","author":"R S Wilson","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"12","key":"ref7","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment","volume":"58","author":"R C Petersen","year":"2001","journal-title":"Arch Neurol"},{"issue":"03","key":"ref8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"R C Petersen","year":"2004","journal-title":"J Intern Med"},{"issue":"04","key":"ref9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1212\/WNL.0000000000000055","article-title":"Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal","volume":"82","author":"R O Roberts","year":"2014","journal-title":"Neurology"},{"issue":"08","key":"ref10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1176\/appi.ajgp.13.8.633","article-title":"Current epidemiology of mild cognitive impairment and other predementia syndromes","volume":"13","author":"F Panza","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"issue":"06","key":"ref11","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1136\/jnnp.2005.085332","article-title":"Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. 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