{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:46:46Z","timestamp":1765889206572,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Intracerebral hemorrhage (ICH) is a deadly disease and increased intracranial pressure (ICP) is associated with worse outcomes in this context.<\/jats:p><jats:p>\n          Objective\u2003We evaluated whether dilated optic nerve sheath diameter (ONSD) depicted by optic nerve ultrasound (ONUS) at hospital admission has prognostic value as a predictor of mortality at 90 days.<\/jats:p><jats:p>\n          Methods\u2003Prospective multicenter study of acute supratentorial primary ICH patients consecutively recruited from two tertiary stroke centers. Optic nerve ultrasound and cranial computed tomography (CT) scans were performed at hospital admission and blindly reviewed. The primary outcome was mortality at 90-days. Multivariate logistic regression, ROC curve, and C-statistics were used to identify independent predictors of mortality.<\/jats:p><jats:p>\n          Results\u2003Between July 2014 and July 2016, 57 patients were evaluated. Among those, 13 were excluded and 44 were recruited into the trial. Their mean age was 62.3\u2009\u00b1\u200913.1 years and 12 (27.3%) were female. On univariate analysis, ICH volume on cranial CT scan, ICH ipsilateral ONSD, Glasgow coma scale, National Institute of Health Stroke Scale (NIHSS) and glucose on admission, and also diabetes mellitus and current nonsmoking were predictors of mortality. After multivariate analysis, ipsilateral ONSD (odds ratio [OR]: 6.24; 95% confidence interval [CI]: 1.18\u201333.01; p\u2009=\u20090.03) was an independent predictor of mortality, even after adjustment for other relevant prognostic factors. The best ipsilateral ONSD cutoff was 5.6mm (sensitivity 72% and specificity 83%) with an AUC of 0.71 (p\u2009=\u20090.02) for predicting mortality at 90 days.<\/jats:p><jats:p>\n          Conclusion\u2003Optic nerve ultrasound is a noninvasive, bedside, low-cost technique that can be used to identify increased ICP in acute supratentorial primary ICH patients. Among these patients, dilated ONSD is an independent predictor of mortality at 90 days.<\/jats:p>","DOI":"10.1055\/s-0043-1775885","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T23:38:01Z","timestamp":1699486681000},"page":"861-867","source":"Crossref","is-referenced-by-count":3,"title":["Dilated optic nerve sheath by ultrasound predicts mortality among patients with acute intracerebral hemorrhage"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-4550","authenticated-orcid":false,"given":"Francisco Antunes","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-0660","authenticated-orcid":false,"given":"Maria Clara Zanon","family":"Zotin","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Medicina Interna, Divis\u00e3o de Radiologia, Ribeir\u00e3o Preto SP, Brazil."},{"name":"Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-5358","authenticated-orcid":false,"given":"Frederico Fernandes","family":"Alessio-Alves","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-5938","authenticated-orcid":false,"given":"Rui Kleber do Vale","family":"Martins Filho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-9969","authenticated-orcid":false,"given":"Clara Monteiro Antunes","family":"Barreira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-1797","authenticated-orcid":false,"given":"Otavio Costa","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-2255","authenticated-orcid":false,"given":"Paula Mu\u00f1oz","family":"Venturelli","sequence":"additional","affiliation":[{"name":"Universidad del Desarrollo, Facultad de Medicina Cl\u00ednica Alemana, Instituto de Ciencias e Innovaci\u00f3n en Medicina, Centro de Estudios Cl\u00ednicos, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-9205","authenticated-orcid":false,"given":"Gregoire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-1828","authenticated-orcid":false,"given":"Joshua Norkin","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-843X","authenticated-orcid":false,"given":"Octavio Marques","family":"Pontes-Neto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Hospital das Cl\u00ednicas, Departamento de Neuroci\u00eancias e 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