{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:25:34Z","timestamp":1766579134269,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary laryngeal sarcomas are rare. Their nomenclature and classification are similar to soft tissue counterparts; however, there are notable differences between clinical presentation, behavior, treatment, and follow-up. There is sparse information regarding the clinical features, biologic behavior, and treatment modalities of laryngeal sarcomas. To increase our understanding about these tumors, we describe herein an additional series of four cases of different pathologic types of laryngeal sarcomas, including low-grade chondrosarcoma, leiomyosarcoma, well-differentiated liposarcoma, and undifferentiated pleomorphic sarcoma. Our main aim is to upsurge awareness about the morphologic variations of laryngeal sarcomas, to avoid potential pitfalls during histopathologic examination. It is essential to ensure that correct diagnosis, subclassification, and grading are achieved for proper guidance of treatment and clinical follow-up at multidisciplinary team meetings.<\/jats:p>","DOI":"10.1055\/s-0043-1775997","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:04:22Z","timestamp":1702339462000},"page":"247-252","source":"Crossref","is-referenced-by-count":4,"title":["Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types"],"prefix":"10.1055","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-7352","authenticated-orcid":false,"given":"Ala S.","family":"Abu-Dayeh","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled A.","family":"Murshed","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adham","family":"Ammar","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-8075","authenticated-orcid":false,"given":"Mahir","family":"Petkar","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Hamad Medical Corporation, Doha 576214, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12105-021-01314-8","article-title":"Primary sarcomas of the larynx: a clinicopathologic study of 27 cases","volume":"15","author":"J M Velez Torres","year":"2021","journal-title":"Head Neck Pathol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hed.26604","article-title":"Laryngeal soft tissue sarcoma: systematic review and individual patient data analysis of 300 cases","volume":"43","author":"A V Ramdulari","year":"2021","journal-title":"Head Neck"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3390\/medicina57030192","article-title":"Sarcomas of the larynx: one institution's experience and treatment protocol analyses","volume":"57","author":"J Astl","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.anndiagpath.2018.09.007","article-title":"Laryngeal sarcomas: a case series of 5 cases","volume":"37","author":"B AbdullGaffar","year":"2018","journal-title":"Ann Diagn Pathol"},{"issue":"03","key":"ref5","first-page":"1105","article-title":"A report of 4 laryngeal sarcoma patients","volume":"4","author":"\u00d6 Bay\u0131r","year":"2016","journal-title":"JSM Clin Case Rep."},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/00000478-200207000-00002","article-title":"Chondrosarcoma of the larynx: a clinicopathologic study of 111 cases with a review of the literature","volume":"26","author":"L D Thompson","year":"2002","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"ref7","first-page":"2601","article-title":"Chondrosarcomas of the head and neck","volume":"271","author":"A Coca-Pelaz","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/01945998211004578","article-title":"Laryngeal chondrosarcoma characteristics and survival analysis in the National Cancer Database","volume":"166","author":"V M Talati","year":"2022","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1258\/0022215001905698","article-title":"Laryngeal leiomyosarcoma","volume":"114","author":"G Marioni","year":"2000","journal-title":"J Laryngol Otol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjoto.2004.11.007","article-title":"Leiomyosarcoma of the larynx: critical analysis of the diagnostic role played by immunohistochemistry","volume":"26","author":"G Marioni","year":"2005","journal-title":"Am J Otolaryngol"},{"key":"ref11","first-page":"2925","article-title":"Chondrosarcoma of the larynx and review of the literature","volume":"27","author":"A Sauter","year":"2007","journal-title":"Anticancer Res"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00000478-199002000-00005","article-title":"Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts","volume":"14","author":"B M Wenig","year":"1990","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/01.pas.0000170343.09562.39","article-title":"MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data","volume":"29","author":"M B Binh","year":"2005","journal-title":"Am J Surg Pathol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12105-021-01341-5","article-title":"Well-differentiated liposarcoma of the hypopharynx exhibiting myxoid liposarcoma-like morphology with MDM2 and DDIT3 co-amplification","volume":"16","author":"K A Murshed","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"12","key":"ref15","first-page":"E12","article-title":"Undifferentiated pleomorphic sarcoma of the vocal fold","volume":"95","author":"C Y Jeong","year":"2016","journal-title":"Ear Nose Throat J"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/ajot.2001.22579","article-title":"Radiation-induced malignant fibrous histiocytoma of the neck in a patient with laryngeal carcinoma","volume":"22","author":"I Haberal","year":"2001","journal-title":"Am J Otolaryngol"},{"key":"ref17","first-page":"14","article-title":"Undifferentiated high-grade pleomorphic sarcoma of the larynx treated with partial laringectomy","volume":"86","author":"E Cambruzzi","year":"2020","journal-title":"Rev Bras Otorrinolaringol (Engl Ed)"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000514977","article-title":"Glottic malignant fibrous histiocytoma: a case report and literature review","volume":"14","author":"A A Aljariri","year":"2021","journal-title":"Case Rep Oncol"}],"container-title":["Avicenna Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1775997.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:02:16Z","timestamp":1703203336000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1775997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":18,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,12,21]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1775997","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2231-0770","2249-4464"],"issn-type":[{"type":"print","value":"2231-0770"},{"type":"electronic","value":"2249-4464"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}