{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:23:47Z","timestamp":1773851027861,"version":"3.50.1"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"National Institutes of Child Health and Human Development","award":["1R01HD077592"],"award-info":[{"award-number":["1R01HD077592"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Prior stillbirth increases risk of subsequent stillbirth but has unclear effect on subsequent liveborn pregnancies. We examined associations between prior stillbirth, adverse neonatal outcomes, and maternal morbidity in subsequent liveborn pregnancies.<\/jats:p><jats:p>\n            Study Design\u2003This is a secondary analysis of a large, National Institutes of Health-funded retrospective cohort study of parturients who delivered a singleton infant at a tertiary-care hospital from January 2002 to March 2013 and had a past medical\/obstetric history of diabetic, and\/or hypertensive disorders, and\/or pregnancy with fetal growth restriction. Our analysis included all multiparous patients from the parent study. The primary outcome was a neonatal morbidity composite (neonatal resuscitation, neonatal birth injury, respiratory distress syndrome, transient tachypnea of the newborn, hypoglycemia, sepsis). Secondary outcomes included a maternal morbidity composite (venous thromboembolism, intensive care unit admission, disseminated intravascular coagulation, sepsis, hysterectomy, pulmonary edema, renal failure, blood transfusion), other maternal\/delivery complications, and neonatal intensive care unit (NICU) admission. Outcomes were compared between those with versus without prior stillbirth. Negative binomial regression controlled for maternal comorbidities and delivery year.<\/jats:p><jats:p>\n            Results\u2003Among 171 and 5,245 multiparous parturients with versus without prior stillbirth, respectively, those with prior stillbirth had higher rates of pregestational diabetes, autoimmune disease, and clotting disorders. After controlling for these differences and delivery year, infants of parturients with prior stillbirth had similar risk of composite neonatal morbidity (adjusted relative ratio [aRR] 1.19; 95% confidence interval [CI] 0.99\u20131.45) but higher risk of NICU admission (aRR 1.42; 95% CI 1.06\u20131.91) compared with infants of parturients without prior stillbirth, despite delivering at similar gestational ages. Multiparous patients with prior stillbirth had equal maternal morbidity risk but higher risk of developing preeclampsia with severe features (aRR 2.11; 95% CI 1.19\u20133.72).<\/jats:p><jats:p>\n            Conclusion\u2003Compared with high-risk multiparous patients without prior stillbirth, those with prior stillbirth have higher risk of NICU admission and preeclampsia with severe features.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1776349","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:19:05Z","timestamp":1698797945000},"page":"e3018-e3024","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Neonatal and Maternal Outcomes of Pregnancies following Stillbirth"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7734-5804","authenticated-orcid":false,"given":"Eleanor S.","family":"Brakewood","sequence":"additional","affiliation":[{"name":"Department of Medical Education, The Warren Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Stoever","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Boston Medical Center, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phinnara","family":"Has","sequence":"additional","affiliation":[{"name":"Division of Research, Lifespan Health System, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-407X","authenticated-orcid":false,"given":"Nina K.","family":"Ayala","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of OB\/GYN, Women and Infants Hospital of Rhode Island, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery A.","family":"Danilack-Fekete","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Savitz","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Women and Infants Hospital of Rhode Island, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8706-1409","authenticated-orcid":false,"given":"Adam K.","family":"Lewkowitz","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of OB\/GYN, Women and Infants Hospital of Rhode Island, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/GRF.0b013e3181eba25e","article-title":"Management of pregnancy after stillbirth","volume":"53","author":"U M Reddy","year":"2010","journal-title":"Clin Obstet Gynecol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/tog.12708","article-title":"Care in pregnancies subsequent to stillbirth or perinatal death","volume":"23","author":"N Graham","year":"2021","journal-title":"Obstet Gynaecol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1479-828X.2001.tb01290.x","article-title":"Subsequent birth outcomes after an unexplained stillbirth: preliminary population-based retrospective cohort study","volume":"41","author":"S Robson","year":"2001","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"h3080","DOI":"10.1136\/bmj.h3080","article-title":"Risk of recurrent stillbirth: systematic review and meta-analysis","volume":"350","author":"K Lamont","year":"2015","journal-title":"BMJ"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-0528.2010.02641.x","article-title":"Recurrence risk of stillbirth in a second pregnancy","volume":"117","author":"S Bhattacharya","year":"2010","journal-title":"BJOG"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.ajog.2005.03.074","article-title":"Etiology and prevention of stillbirth","volume":"193","author":"R C Fretts","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/AOG.0b013e31824781f8","article-title":"Stillbirth risk in a second pregnancy","volume":"119","author":"A Gordon","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref8","first-page":"31","article-title":"Risk of recurrent stillbirth in subsequent pregnancies","volume":"139","author":"K Lamont","year":"2022","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1097\/AOG.0000000000003719","article-title":"Management of stillbirth: Obstetric Care Consensus No, 10","volume":"135","author":"T D Metz","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"100486","DOI":"10.1016\/j.ajogmf.2021.100486","article-title":"Pregnancy after stillbirth: maternal and neonatal outcomes and health service utilization","volume":"4","author":"R Roseingrave","year":"2022","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1523-536x.2000.00033.x","article-title":"Pregnancy outcome after previous stillbirth resulting from causes other than maternal conditions and fetal abnormalities","volume":"27","author":"S Heinonen","year":"2000","journal-title":"Birth"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1471-0528.2007.01562.x","article-title":"Obstetric outcomes subsequent to intrauterine death in the first pregnancy","volume":"115","author":"M Black","year":"2008","journal-title":"BJOG"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"378.e1","DOI":"10.1016\/j.ajog.2009.06.071","article-title":"The association between stillbirth in the first pregnancy and subsequent adverse perinatal outcomes","volume":"201","author":"D Getahun","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/aogs.14076","article-title":"Can information regarding the index stillbirth determine risk of adverse outcome in a subsequent pregnancy? Findings from a single-center cohort study","volume":"100","author":"N Graham","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"08","key":"ref15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1515\/jpm-2019-0425","article-title":"Stillbirth and subsequent pregnancy outcome - a cohort from a large tertiary referral hospital","volume":"48","author":"M Pekkola","year":"2020","journal-title":"J Perinat Med"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1515\/jpm-2013-0013","article-title":"Subsequent pregnancy after stillbirth: obstetrical and medical risks","volume":"41","author":"K Ofir","year":"2013","journal-title":"J Perinat Med"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"e0155761","DOI":"10.1371\/journal.pone.0155761","article-title":"Adverse perinatal outcome in subsequent pregnancy after stillbirth by placental vascular disorders","volume":"11","author":"F Monari","year":"2016","journal-title":"PLoS ONE"},{"issue":"04","key":"ref18","first-page":"289","article-title":"Pregnancy outcome after stillbirth","volume":"52","author":"S Lurie","year":"2007","journal-title":"J Reprod Med"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/EDE.0000000000001442","article-title":"Health outcomes associated with clinician-initiated delivery for hypertensive disorders at 34-38 weeks' gestation","volume":"33","author":"D A Savitz","year":"2022","journal-title":"Epidemiology"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12884-016-0891-2","article-title":"Marvellous to mediocre: findings of national survey of UK practice and provision of care in pregnancies after stillbirth or neonatal death","volume":"16","author":"T A Mills","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/1471-0528.14424","article-title":"Care in subsequent pregnancies following stillbirth: an international survey of parents","volume":"125","author":"A M Wojcieszek","year":"2018","journal-title":"BJOG"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/jp.2009.133","article-title":"Management of subsequent pregnancy after an unexplained stillbirth","volume":"30","author":"S J Robson","year":"2010","journal-title":"J Perinatol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1776349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:46:02Z","timestamp":1730814362000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1776349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":22,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1776349","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]}}}