{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:18:13Z","timestamp":1783009093711,"version":"3.54.5"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003We evaluated the association between the triglyceride\u2013glucose (TG) index, a marker of insulin resistance, and obstructive sleep apnoea (OSA) severity in patients without diabetes mellitus, obesity, and metabolic syndrome.<\/jats:p><jats:p>\n          Methods\u2003This retrospective cohort study included 1,527 patients. We used univariate and multivariate analyses to identify the independent predictors associated with OSA.<\/jats:p><jats:p>\n          Results\u2003Most patients were males (81.5%) with a mean age of 43.9\u2009\u00b1\u200911.1 (15\u201390) years. Based on the apnoea\u2013hypopnea index (AHI), 353 (23.1%) patients were included in the control group, whereas 32.4%, 23.5%, and 21% had mild, moderate, and severe OSA, respectively. The TG index values demonstrated significant associations with OSA patients compared with the control group (p\u2009=\u20090.001). In addition, the mean values of the oxygen desaturation index (ODI), AHI, minimum oxygen saturation, and total sleep time percentage with saturation below 90% demonstrated statistically significant differences among the TG index groups (p: 0.001; p:0.001; p:0.001; p:0.003). The optimal TG index cutoff value to predict OSA was 8.615 (AUC\u2009=\u20090.638, 95% CI\u2009=\u20090.606\u20130.671, p\u2009=\u20090.001). In multivariate logistic regression analysis, after adjusting for age, sex, and body mass index, the TG index was independently associated with OSA patients.<\/jats:p><jats:p>\n          Conclusion\u2003The TG index is independently associated with increased risk for OSA. This indicates that this index, a marker for disease severity, can be used to identify severe OSA patients on waiting lists for PSG.<\/jats:p>","DOI":"10.1055\/s-0043-1776411","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T23:38:01Z","timestamp":1699486681000},"page":"891-897","source":"Crossref","is-referenced-by-count":5,"title":["Triglyceride-glucose index as a predictor of obstructive sleep apnoea severity in the absence of traditional risk factors"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-2075","authenticated-orcid":false,"given":"Sinem Nedime","family":"S\u00f6k\u00fcc\u00fc","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-9056","authenticated-orcid":false,"given":"\u015eenay","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5457-9551","authenticated-orcid":false,"given":"Celal","family":"Sat\u0131c\u0131","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-0392","authenticated-orcid":false,"given":"Seda","family":"Tural \u00d6n\u00fcr","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-8885","authenticated-orcid":false,"given":"Cengiz","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Liv Hospital, Vadi Istanbul, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"N M Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"04","key":"ref2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"R Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"ref3","first-page":"7","article-title":"Diagnostic Acuracy of the Triglyceride and Glucose Index for Insulin Resistance: A systemic review","volume":"x","author":"A Sanchez Garcia","year":"2020","journal-title":"Int J Endocrinology Volume"},{"issue":"03","key":"ref4","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1016\/j.diabres.2011.05.030","article-title":"TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study","volume":"93","author":"A C Vasques","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"issue":"06","key":"ref5","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.pcd.2020.09.001","article-title":"Triglyceride-glucose index predicts independently type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies","volume":"14","author":"A da Silva","year":"2020","journal-title":"Prim Care Diabetes"},{"issue":"07","key":"ref6","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1210\/en.2018-00248","article-title":"Obstructive Sleep Apnea Syndrome and Metabolic Diseases","volume":"159","author":"M Li","year":"2018","journal-title":"Endocrinology"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.chest.2017.05.009","article-title":"Obstructive Sleep Apnea and Diabetes: A State of the Art Review","volume":"152","author":"S Reutrakul","year":"2017","journal-title":"Chest"},{"issue":"04","key":"ref8","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/oby.23679","article-title":"Obstructive sleep apnea and metabolic syndrome","volume":"31","author":"S QC Giamp\u00e1","year":"2023","journal-title":"Obesity (Silver Spring)"},{"issue":"01","key":"ref9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11325-012-0760-9","article-title":"Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism","volume":"18","author":"A M Adedayo","year":"2014","journal-title":"Sleep Breath"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"P L Huang","year":"2009","journal-title":"Dis Model Mech"},{"issue":"04","key":"ref11","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s11325-019-01980-7","article-title":"The use of visceral adiposity variables in the prediction of obstructive sleep apnea: evidence from a large cross-sectional study","volume":"24","author":"J Zou","year":"2020","journal-title":"Sleep Breath"},{"issue":"01","key":"ref12","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12944-020-01358-9","article-title":"Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study","volume":"19","author":"H H Kang","year":"2020","journal-title":"Lipids Health Dis"},{"issue":"02","key":"ref13","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s11325-014-1053-2","article-title":"Relationship of obstructive sleep apnea and cardiometabolic risk factors in elderly patients with abdominal aortic aneurysm","volume":"19","author":"V E Bianchi","year":"2015","journal-title":"Sleep Breath"},{"issue":"09","key":"ref14","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.3390\/jcm10091932","article-title":"Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea","volume":"10","author":"A Bikov","year":"2021","journal-title":"J Clin Med"},{"issue":"04","key":"ref15","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1378\/chest.11-1844","article-title":"Sleep apnea and glucose metabolism: a long-term follow-up in a community-based sample","volume":"142","author":"E Lindberg","year":"2012","journal-title":"Chest"},{"issue":"03","key":"ref16","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.ecl.2013.05.001","article-title":"Sleep disorders and the development of insulin resistance and obesity","volume":"42","author":"O Mesarwi","year":"2013","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"P E Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41371-020-0326-4","article-title":"Association of triglyceride-glucose index and its interaction with obesity on hypertension risk in Chinese: a population-based study","volume":"35","author":"K Wang","year":"2021","journal-title":"J Hum Hypertens"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12933-020-01077-6","article-title":"A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study","volume":"19","author":"B Zhu","year":"2020","journal-title":"Cardiovasc Diabetol"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.numecd.2019.07.003","article-title":"Temporal relationship between body mass index and triglyceride-glucose index and its impact on the incident of hypertension","volume":"29","author":"Y Xie","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"01","key":"ref22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1378\/chest.14-0500","article-title":"Intermittent hypoxemia and OSA: implications for comorbidities","volume":"147","author":"N A Dewan","year":"2015","journal-title":"Chest"},{"issue":"04","key":"ref23","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2869.2006.00556.x","article-title":"Habitual snoring is associated with elevated hemoglobin A1c levels in non-obese middle-aged adults","volume":"15","author":"S Joo","year":"2006","journal-title":"J Sleep Res"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1776411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T23:38:33Z","timestamp":1699486713000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1776411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1776411","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}