{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:24:00Z","timestamp":1773797040211,"version":"3.50.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Sickle cell disorder (SCD) is a hereditary blood disease characterized by an abnormality in the oxygen-carrying protein hemoglobin present in red blood cells. Genetic abnormality causes these cells to become sickle-shaped, with shorter lifespan. Vaso-occlusive crisis is a major symptom of SCD: it is a sudden and severe episode of pain, and occurs when sickle-shaped cells block blood flow. This blockage can lead to tissue damage, inflammation and pain.<\/jats:p><jats:p>\n          Objectives\u2003This case series aims to observe the clinical outcomes from prescribing individualized homeopathic medicines along with organopathic supportive medicine in the management of SCD through the analysis of case studies of six patients from a particularly vulnerable tribal group (PVTG) in India that manifests genetic predisposition for the disease.<\/jats:p><jats:p>\n          Method\u2003The patients were administered individualized homeopathic and organopathic supportive medicines, after a comprehensive door-to-door survey and subsequent screening, conducted between October 2020 and May 2023 in the Dindori and Mandla districts of the central Indian state, Madhya Pradesh. Clinical symptoms, laboratory parameters including hemoglobin, along with scores from a visual analogue scale (VAS) for pain and from the World Health Organization Quality of Life (WHOQoL) Questionnaire, were determined.<\/jats:p><jats:p>\n          Results\u2003Individualized homeopathic and organopathic supportive management led to improvements in clinical symptoms for all six patients. Laboratory test results showed a statistically significant increase in hemoglobin level associated with treatment. The VAS for pain indicated decreased pain frequency and severity. WHOQoL scores also improved, indicating enhanced well-being for each patient. No adverse effects were reported during treatment.<\/jats:p><jats:p>\n          Conclusion\u2003This study suggests that individualized homeopathic medicine and organopathic supportive management have a beneficial role in managing SCD and may be valuable in the context of PVTGs in India. To establish a more comprehensive understanding of its efficacy, further studies should involve larger cohorts to allow for a thorough evaluation, including comparative analyses with standard therapies.<\/jats:p>","DOI":"10.1055\/s-0043-1776908","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:57:45Z","timestamp":1706659065000},"page":"253-261","source":"Crossref","is-referenced-by-count":2,"title":["Individualized Homeopathic and Organopathic Supportive Management of Sickle Cell Disorder: A Case Series of Six Patients from a Particularly Vulnerable Tribal Group in India"],"prefix":"10.1055","volume":"113","author":[{"given":"Nisanth K.M.","family":"Nambison","sequence":"additional","affiliation":[{"name":"Department of AYUSH, Government Homeopathic Medical College and Hospital, Government of Madhya Pradesh, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of AYUSH, Government Homeopathic Medical College and Hospital, Government of Madhya Pradesh, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek D.","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of AYUSH, Government Homeopathic Medical College and Hospital, Government of Madhya Pradesh, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Department of AYUSH, Government Homeopathic Medical College and Hospital, Government of Madhya Pradesh, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1182\/blood-2015-09-618587","article-title":"Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease","volume":"127","author":"M D Hoban","year":"2016","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ijns5020020","article-title":"Sickle cell disease-genetics, pathophysiology, clinical presentation and treatment","volume":"5","author":"B PD Inusa","year":"2019","journal-title":"Int J Neonatal Screen"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"B Modell","year":"2008","journal-title":"Bull World Health 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Encouraging results of a preliminary study","volume":"7","author":"A Banerjee","year":"2010","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.homp.2012.08.005","article-title":"Constitutional, organopathic and combined homeopathic treatment of benign prostatic hypertrophy: a clinical trial","volume":"101","author":"A K Hati","year":"2012","journal-title":"Homeopathy"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.NAJ.0000559779.40570.2c","article-title":"Understanding the complications of sickle cell disease","volume":"119","author":"P Tanabe","year":"2019","journal-title":"Am J Nurs"},{"key":"ref23","first-page":"CD001916","article-title":"Psychological therapies for sickle cell disease and pain","volume":"2015","author":"K A Anie","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref26","first-page":"65","article-title":"Exploring organopathy\u2014its applicability and limitations","volume":"3","author":"M A Billah","year":"2022","journal-title":"IAR J Med Sci"},{"key":"ref27","first-page":"1","article-title":"Comparative study of Ferrum phos 6x versus Ferrum phos 6x along with homoeopathic medicine in the management of anaemia\u2014randomized controlled trial in all age group","volume":"4","author":"F F Motiwala","year":"2022","journal-title":"J Homoeopathy"},{"key":"ref28","first-page":"161","article-title":"Anti-sickling activities of the stem bark of three Khaya species found in Nigeria: K. senegalensis A. 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