{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:07:57Z","timestamp":1763644077904,"version":"3.28.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Postoperative constipation (PC) in patients with imperforate anus and perineal fistula (PF) has been reported in up to 60%. Histological studies of PF revealed innervation anomalies which seem to be one of the reasons for PC. Perioperative histologically controlled fistula resection (PHCFR) allows appropriate resection of PF and pull-down normoganglionic rectum at the time of posterior sagittal anorectoplasty (PSARP).<\/jats:p><jats:p>\n          Materials and Methods\u2003A total of 665 patients with anorectal malformations underwent surgery between 1991 and 2021. Of these, 364 presented PF; 92 out of them (41 F) were studied. Patients with sacral and spinal cord anomalies, neurological disorders, and cut-back anoplasty were excluded. PSARP was done on all patients. Hematoxylin-eosin staining and NADH Tetrazolium-reductase histochemical method were used. Four and more ganglion cells in the myenteric plexus represented a sufficient length of the resection. The continence was scored according to the modified Krickenbeck scoring system. Final scores ranged from 1 to 7 points. Values are given as median.<\/jats:p><jats:p>\n          Results\u2003A total of 65 (70.7%) patients presented an aganglionic segment in PF, and 27 patients presented hypoganglionosis. The median length of the resected fistula was 25\u2009mm (interquartile range [IQR]: 20\u201330). The median total continence score was 7 (IQR: 6\u20137). Post-op constipation was observed in 6\/92 (6.5%) patients.<\/jats:p><jats:p>\n          Conclusion\u2003PHCFR diminished PC to 6.5% of patients.<\/jats:p>","DOI":"10.1055\/s-0043-1777101","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:10:21Z","timestamp":1701216621000},"page":"418-422","source":"Crossref","is-referenced-by-count":1,"title":["Perioperative Histologically Controlled Fistula Resection in Patients with Imperforate Anus and Perineal Fistula"],"prefix":"10.1055","volume":"34","author":[{"given":"Richard","family":"Skaba","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojtech","family":"Dotlacil","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavla","family":"Fuccillo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Rouskova","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Pos","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech 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