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The neurological manifestations caused by these viruses have a high potential for death or sequelae. The complications that occur in the nervous system associated with arboviruses can be a challenge for diagnosis and treatment. In endemic areas, suspected cases should include acute encephalitis, myelitis, encephalomyelitis, polyradiculoneuritis, and\/or other syndromes of the central or peripheral nervous system, in the absence of a known explanation. The confirmation diagnosis is based on viral (isolation or RT-PCR) or antigens detection in tissues, blood, cerebrospinal fluid, or other body fluids, increase in IgG antibody titers between paired serum samples, specific IgM antibody in cerebrospinal fluid and serological conversion to IgM between paired serum samples (non-reactive in the acute phase and reactive in the convalescent). The cerebrospinal fluid examination can demonstrate: 1. etiological agent; 2. inflammatory reaction or protein-cytological dissociation depending on the neurological condition; 3. specific IgM, 4. intrathecal synthesis of specific IgG (dengue and chikungunya); 5. exclusion of other infectious agents. The treatment of neurological complications aims to improve the symptoms, while the vaccine represents the great hope for the control and prevention of neuroinvasive arboviruses. This narrative review summarizes the updated epidemiology, general features, neuropathogenesis, and neurological manifestations associated with dengue, zika, and chikungunya infection.<\/jats:p>","DOI":"10.1055\/s-0043-1777104","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:05:43Z","timestamp":1703894743000},"page":"1112-1124","source":"Crossref","is-referenced-by-count":26,"title":["Review of dengue, zika and chikungunya infections in nervous system in endemic areas"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-9142","authenticated-orcid":false,"given":"Marzia","family":"Puccioni-Sohler","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Departamento de Medicina Geral, Rio de Janeiro RJ, Brazil."},{"name":"Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-4006","authenticated-orcid":false,"given":"Cristiane","family":"Nascimento Soares","sequence":"additional","affiliation":[{"name":"Hospital Federal dos Servidores do Estado, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-5243","authenticated-orcid":false,"given":"Paulo Pereira","family":"Christo","sequence":"additional","affiliation":[{"name":"Santa Casa BH, Faculdade de Sa\u00fade, Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Medicina-Biomedicina, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Neurologia, Belo Horizonte MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-105X","authenticated-orcid":false,"given":"S\u00e9rgio Monteiro de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Faculdade de Medicina, Departamento de Patologia M\u00e9dica, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref1","first-page":"48","volume-title":"Manual de Vigil\u00e2ncia Sentinela de Doen\u00e7as Neuroinvasivas por Arbov\u00edrus","author":"Minist\u00e9rio da Sa\u00fade (MS). 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