{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:26:19Z","timestamp":1791325579515,"version":"4.3.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Vitamin B12 deficiency can lead to hematological findings, neurological symptoms, and neurodevelopmental delay. The aim of this study was to investigate the impact of vitamin B12 deficiency on the neurodevelopment of children.<\/jats:p><jats:p>\n          Materials and Methods\u2003This study included 89 children aged between 6 and 24 months without any complaints; 44 of these were evaluated in the study group (serum vitamin B12 &lt;300 pg\/mL) and 45 in the control group (serum vitamin B12 \u2265300 pg\/mL). Denver Developmental Screening Test II (DDST-II) and the Social Communication Area Screening Test (SCAST) were evaluated in each participant.<\/jats:p><jats:p>\n          Results\u2003The mean vitamin B12 level in the study group was 206.11\u2009\u00b1\u20099.1 pg\/mL, and in the control group, it was 540.65\u2009\u00b1\u200924.1 pg\/mL. When DDST-II results were analyzed, the rate of getting suspicious and abnormal results in the study group was significantly higher compared with the control group (p\u2009=\u20090.001). The rate of the \u201crisky\u201d SCAST results of the cases was found to be statistically significantly higher in the study group than in the control group (p\u2009=\u20090.003). Vitamin B12 values of patients with suspicious or abnormal DDST-II results and with risky SCAST results were found to be statistically significantly lower than those with normal neurodevelopmental screening tests results (p\u2009=\u20090.001 and p\u2009=\u20090.001, respectively).<\/jats:p><jats:p>\n          Conclusion\u2003Vitamin B12 deficiency can lead to neurodevelopmental delay in children, even in the absence of neurological and hematological symptoms or complaints, which highlights the importance of early detection and intervention of vitamin B12 deficiency.<\/jats:p>","DOI":"10.1055\/s-0043-1777125","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T23:52:57Z","timestamp":1703116377000},"page":"097-103","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Neurodevelopmental Screening Test Scores in Children with Vitamin B12 Deficiency"],"prefix":"10.1055","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9574-3178","authenticated-orcid":false,"given":"Ceren","family":"Tanc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Tekirda\u011f Nam\u0131k Kemal University, Tekirda\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-8394","authenticated-orcid":false,"given":"Ismail","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Yalova University, Yalova, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"ref1","volume-title":"Harper's Illustrated Biochemistry","author":"P J Kennelly","year":"2022","edition":"32th ed."},{"key":"ref2","volume-title":"Lehninger Principles of Biochemistry","author":"D L Nelson","year":"2021","edition":"8th ed."},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1067\/mpd.2001.112160","article-title":"Vitamin B12 deficiency in children and adolescents","volume":"138","author":"S A Rasmussen","year":"2001","journal-title":"J Pediatr"},{"issue":"19","key":"ref4","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1182\/blood-2016-10-569186","article-title":"Vitamin B12 deficiency from the perspective of a practicing hematologist","volume":"129","author":"R Green","year":"2017","journal-title":"Blood"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3476(67)80070-2","article-title":"The Denver developmental screening test","volume":"71","author":"W K Frankenburg","year":"1967","journal-title":"J Pediatr"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1542\/peds.109.1.144","article-title":"Developmental surveillance and screening of infants and young children","volume":"109","author":"W K Frankenburg","year":"2002","journal-title":"Pediatrics"},{"key":"ref7","first-page":"87","article-title":"Social Communication Area Screening Test (SCAST) for detecting developmental risk in infancy and early childhood","volume":"58","author":"N K Sertgil","year":"2015","journal-title":"J Child Health Dis"},{"key":"ref8","volume-title":"The Social-Communication Area Screening Test for Infants and Young Children (SCASI): Norms, Reliability and Validity. 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