{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:29:53Z","timestamp":1792877393033,"version":"4.5.0"},"reference-count":115,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The filamentous fungus Aspergillus causes a wide spectrum of diseases in the human lung, with Aspergillus fumigatus being the most pathogenic and allergenic subspecies. The broad range of clinical syndromes that can develop from the presence of Aspergillus in the respiratory tract is determined by the interaction between host and pathogen. In this review, an oversight of the different clinical entities of pulmonary aspergillosis is given, categorized by their main pathophysiological mechanisms. The underlying immune processes are discussed, and the main clinical, radiological, biochemical, microbiological, and histopathological findings are summarized.<\/jats:p>","DOI":"10.1055\/s-0043-1777259","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T18:49:32Z","timestamp":1706554172000},"page":"003-020","source":"Crossref","is-referenced-by-count":48,"title":["Aspergillus and the Lung"],"prefix":"10.1055","volume":"45","author":[{"given":"Iris","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"},{"name":"Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium"},{"name":"VIB Center for Inflammation Research, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"},{"name":"Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium"},{"name":"VIB Center for Inflammation Research, Ghent, Belgium"},{"name":"Department of Pulmonary Medicine, ErasmusMC; Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Van Braeckel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"},{"name":"Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","volume-title":"Aspergillus Species","author":"T F Patterson","year":"2019"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"633047","DOI":"10.3389\/fmicb.2021.633047","article-title":"Role for IL-1 family cytokines in fungal infections","volume":"12","author":"J S Griffiths","year":"2021","journal-title":"Front Microbiol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/thoraxjnl-2014-206291","article-title":"The clinical spectrum of pulmonary aspergillosis","volume":"70","author":"C Kosmidis","year":"2015","journal-title":"Thorax"},{"issue":"165","key":"ref4","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"G D Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"ref5","volume-title":"Introduction to the History of Mycology","author":"G C Ainsworth","year":"1976"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3114\/sim.2007.59.05","article-title":"Aspergillus species identification in the clinical setting","volume":"59","author":"S A Balajee","year":"2007","journal-title":"Stud Mycol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"a019786","DOI":"10.1101\/cshperspect.a019786","article-title":"Aspergillus fumigatus and related species","volume":"5","author":"J A Sugui","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.mib.2005.06.017","article-title":"Aspergillus fumigatus: saprophyte or pathogen?","volume":"8","author":"F Tekaia","year":"2005","journal-title":"Curr Opin Microbiol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1439-0507.2007.01453.x","article-title":"Invasive pulmonary aspergillosis in neutropenic patients and the influence of hospital renovation","volume":"51","author":"G Pini","year":"2008","journal-title":"Mycoses"},{"issue":"09","key":"ref11","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/b402995j","article-title":"Indoor air quality during renovation actions: a case study","volume":"6","author":"A A Abdel Hameed","year":"2004","journal-title":"J Environ Monit"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.riam.2010.10.003","article-title":"What makes Aspergillus fumigatus a successful pathogen? 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