{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:31:18Z","timestamp":1762097478315,"version":"build-2065373602"},"reference-count":228,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the second most highly cited paper ever published in STH. The manuscript published without an abstract, and essentially represented a State of the Art Review on the bleeding time, a relatively invasive procedure that required an incision on the skin or earlobe of a patient, and timing how long it took for the incision to stop bleeding. The bleeding time test was first described in 1901 by the French physician Milian, who presented three studies of bleeding from stab wounds made in the fingertips of healthy and diseased subjects. In 1910, Duke observed the duration of bleeding from small incisions of the ear lobe, and pointed out that the duration of bleeding was increased in instances of reduced platelet counts. The test was subsequently repeatedly modified, and numerous variants of the test, including semiautomated methods, were described by several workers. The most frequently utilised test reflected one described by Ivy and coworkers, who shifted the location of the incision to the volar aspect of the forearm and applied a blood pressure cuff to the arm to maintain a standard venous pressure. The bleeding time has been proposed for use as a diagnostic test for platelet-related bleeding disorders, a measure of efficacy in various forms of therapy, and as a prognosticator of abnormal bleeding. The authors to the current review reevaluated the bleeding time literature using methods to assess the performance of the test in 1990, locating 862 printed documents that discussed the bleeding time, the majority in peer-reviewed professional journals. As this is a republication of archival material, transformed into a modern format, we apologise in advance for any errors introduced during this transformation.<\/jats:p>","DOI":"10.1055\/s-0043-1777307","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:05:28Z","timestamp":1702425928000},"page":"499-516","source":"Crossref","is-referenced-by-count":5,"title":["A Critical Reappraisal of the Bleeding Time"],"prefix":"10.1055","volume":"50","author":[{"given":"R. P. Channing","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, University of California, San Francisco, California"},{"name":"The Veterans Administration Medical Center, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, University of California, San Francisco, California"},{"name":"The Veterans Administration Medical Center, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"ref1","first-page":"576","article-title":"Influence de la peau sur la coagulabilite du sang","volume":"53","author":"M G Milian","year":"1901","journal-title":"C R Soc Biol (Paris)"},{"key":"ref2","first-page":"556","article-title":"Contribution a l'etude de la coagulation du sang","volume":"53","author":"M G Milian","year":"1901","journal-title":"C R Soc Biol (Paris)"},{"key":"ref3","first-page":"777","article-title":"Technique pour l'etude clinique de la coagulation du sang","volume":"18","author":"M G Milian","year":"1901","journal-title":"Bull Mem Soc Med Hop Paris"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/jama.1910.04330140029009","article-title":"The relation of blood platelets to hemorrhagic disease. Description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion","volume":"55","author":"W W Duke","year":"1910","journal-title":"JAMA"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/ajcp\/55.5.541","article-title":"Bleeding from standardized skin punctures: automated technic for recording time, intensity, and pattern of bleeding","volume":"55","author":"A H Sutor","year":"1971","journal-title":"Am J Clin Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0609.1980.tb01344.x","article-title":"Standardization of the bleeding time","volume":"37","author":"E JW Bowie","year":"1980","journal-title":"Scand J Haematol Suppl"},{"key":"ref7","first-page":"1812","article-title":"The standardization of certain factors in the cutaneous \u201cvenostasis\u201d bleeding time technique","volume":"26","author":"A C Ivy","year":"1941","journal-title":"J Lab Clin Med"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/blood.V34.2.204.204","article-title":"The standardized normal Ivy bleeding time and its prolongation by aspirin","volume":"34","author":"C H Mielke Jr","year":"1969","journal-title":"Blood"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/ajcp\/70.3.406","article-title":"Development and evaluation of a disposable device for performing simultaneous duplicate bleeding time determinations","volume":"70","author":"S R Babson","year":"1978","journal-title":"Am J Clin Pathol"},{"issue":"02","key":"ref11","first-page":"89","article-title":"Evaluation of platelet function","volume":"23","author":"H J Day","year":"1986","journal-title":"Semin Hematol"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0001-2998(78)80014-2","article-title":"Basic principles of ROC analysis","volume":"8","author":"C E Metz","year":"1978","journal-title":"Semin Nucl Med"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00004424-197903000-00002","article-title":"ROC analysis applied to the evaluation of medical imaging techniques","volume":"14","author":"J A Swets","year":"1979","journal-title":"Invest Radiol"},{"key":"ref15","first-page":"553","article-title":"Greenland: selection and interpretation of diagnostic tests and procedures","volume":"4","author":"P F Griner","year":"1981","journal-title":"Ann Intern Med"},{"key":"ref16","first-page":"432","volume-title":"A new approach for testing the significance of differences between ROC curves measured from correlated data","author":"C E Metz","year":"1984"},{"volume-title":"Lectures on Biostatistics. An Introduction to Statistics with Applications in Biology and Medicine","year":"1971","author":"D Colquhoun","key":"ref17"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0010-468X(79)90075-8","article-title":"Mlab \u2013 a mathematical modeling tool","volume":"10","author":"G D Knott","year":"1979","journal-title":"Comput Programs Biomed"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1537-2995.1980.20581034500.x","article-title":"Viability and function of platelet concentrates stored in CPD-adenine (CPDA-1)","volume":"20","author":"E P Scott","year":"1980","journal-title":"Transfusion"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1537-2995.1980.20581034501.x","article-title":"Recovery, lifespan, and function of CPD-Adenine (CPDA-1) platelet concentrates stored for up to 72\u2009hours at 4\u2009C","volume":"20","author":"R A Kahn","year":"1980","journal-title":"Transfusion"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.0954-6820.1967.tb11539.x","article-title":"The influence of depth of the cut on the bleeding time","volume":"182","author":"P Stavem","year":"1967","journal-title":"Acta Med Scand"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.0954-6820.1958.tb01782.x","article-title":"The secondary bleeding time; a new method for the differentiation of hemorrhagic diseases","volume":"162","author":"C F Borchgrevink","year":"1958","journal-title":"Acta Med Scand"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2141.1974.tb00458.x","article-title":"Bleeding time from incisions standardized by protruding skin fold method","volume":"26","author":"P Stavem","year":"1974","journal-title":"Br J Haematol"},{"issue":"S 01","key":"ref24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1423-0410.1981.tb00742.x","article-title":"Clinical evaluation of platelet transfusions in thrombocytopenic patients: methods and interpretation","volume":"40","author":"R A Kahn","year":"1981","journal-title":"Vox Sang"},{"issue":"17","key":"ref25","first-page":"1391","article-title":"The reproductiveness of bleeding time tests","volume":"30","author":"U G\u00f6bel","year":"1978","journal-title":"Minerva Pediatr"},{"issue":"7682","key":"ref26","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(70)90314-4","article-title":"Effect of cold on bleeding: Hippocrates vindicated","volume":"2","author":"A H Sutor","year":"1970","journal-title":"Lancet"},{"key":"ref27","first-page":"223","article-title":"The Duke and Ivy methods for determination of the bleeding time","volume":"10","author":"I M Nilsson","year":"1963","journal-title":"Thromb Diath Haemorrh"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.STR.15.2.241","article-title":"Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease","volume":"15","author":"G Boysen","year":"1984","journal-title":"Stroke"},{"issue":"8333","key":"ref29","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(83)91911-6","article-title":"Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid","volume":"1","author":"M Thorngren","year":"1983","journal-title":"Lancet"},{"issue":"25","key":"ref30","first-page":"1597","article-title":"Et forslag til tromboseprofylakse. Eskimo-modellen","volume":"142","author":"J Dyerberg","year":"1980","journal-title":"Ugeskr Laeger"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-2141.1984.tb06103.x","article-title":"Delay in primary haemostasis produced by a fish diet without change in local thromboxane A2","volume":"58","author":"M Thorngren","year":"1984","journal-title":"Br J Haematol"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJM198604103141501","article-title":"In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis","volume":"314","author":"H R Knapp","year":"1986","journal-title":"N Engl J Med"},{"issue":"06","key":"ref33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0049-3848(80)90007-9","article-title":"Acetylsalicylic acid, bleeding time and age","volume":"19","author":"K A J\u00f8rgensen","year":"1980","journal-title":"Thromb Res"},{"issue":"06","key":"ref34","first-page":"552","article-title":"Tiempo de sangr\u00eda de Ivy modificado: valores normales en edad pedi\u00e1trica","volume":"53","author":"E R\u00edos","year":"1982","journal-title":"Rev Chil Pediatr"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/17453678208992182","article-title":"Bleeding time and scoliosis","volume":"53","author":"A Ud\u00e9n","year":"1982","journal-title":"Acta Orthop Scand"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1055\/s-0038-1665330","article-title":"Differences between heterozygous dominant and recessive von Willebrand's disease type I expressed by bleeding symptoms and combinations of factor VIII variables","volume":"50","author":"T B Wahlberg","year":"1983","journal-title":"Thromb Haemost"},{"key":"ref37","first-page":"64A","article-title":"Bleeding time values in children are longer than in adults. (Abst.)","volume":"35","author":"J M Sanders","year":"1987","journal-title":"Clin Res"},{"issue":"03","key":"ref38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/jcp.4.3.272","article-title":"The bleeding time in normal and abnormal subjects","volume":"4","author":"J R O'Brien","year":"1951","journal-title":"J Clin Pathol"},{"issue":"7805","key":"ref39","first-page":"694","article-title":"Stressed template bleeding-time and other platelet-function tests in myocardial infarction","volume":"1","author":"J R O'Brien","year":"1973","journal-title":"Lancet"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0038-1650033","article-title":"A sex difference in the bleeding time","volume":"43","author":"B Bain","year":"1980","journal-title":"Thromb Haemost"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/00016348109155470","article-title":"Von Willebrand's disease and pregnancy","volume":"60","author":"R Punnonen","year":"1981","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"02","key":"ref42","first-page":"483","article-title":"Blood changes in atherosclerosis and long after myocardial infarction and venous thrombosis","volume":"34","author":"J R O'Brien","year":"1975","journal-title":"Thromb Diath Haemorrh"},{"key":"ref43","first-page":"355","article-title":"Corticotherapie dans les allongements du temps de saignement","volume":"3","author":"J Caen","year":"1963","journal-title":"Nouv Rev Fr Hematol"},{"key":"ref44","first-page":"304","article-title":"La place du temps de saignement dans l'exploration actuelle des thrombopenies","volume":"3","author":"G Marchal","year":"1963","journal-title":"Nouv Rev Fr Hematol"},{"key":"ref45","first-page":"558","article-title":"Les correlations entre le temps de saignement et l'adhesivite plaquettaire \u2018in vivo\u2019 au cours de divers etats hemorrhagiques","volume":"12","author":"A Parquet-Gernez","year":"1964","journal-title":"Pathol Biol (Paris)"},{"issue":"13","key":"ref46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM196903272801301","article-title":"Platelet function in renal failure","volume":"280","author":"G Eknoyan","year":"1969","journal-title":"N Engl J Med"},{"key":"ref47","first-page":"302","article-title":"Evidence that the spleen retains the youngest and hemostatically most effective platelets","volume":"81","author":"N R Shulman","year":"1968","journal-title":"Trans Assoc Am Physicians"},{"issue":"04","key":"ref48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1056\/NEJM197207272870401","article-title":"The bleeding time as a screening test for evaluation of platelet function","volume":"287","author":"L A Harker","year":"1972","journal-title":"N Engl J Med"},{"issue":"10","key":"ref49","first-page":"401","article-title":"Die Blutungszeitbestimmung im Kindesalter und ihre klinische Anwendung","volume":"25","author":"A H Sutor","year":"1974","journal-title":"Med Welt"},{"issue":"02","key":"ref50","first-page":"298","article-title":"The hemostatic mechanism after open-heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation","volume":"70","author":"R McKenna","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1537-2995.1976.16176130829.x","article-title":"Storage of platelet concentrates","volume":"16","author":"R A Kahn","year":"1976","journal-title":"Transfusion"},{"issue":"03","key":"ref53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2141.1976.tb03586.x","article-title":"Preparation and storage of platelet concentrates. I. Factors influencing the harvest of viable platelets from whole blood","volume":"34","author":"S J Slichter","year":"1976","journal-title":"Br J Haematol"},{"issue":"08","key":"ref54","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/archinte.1978.03630330051014","article-title":"Template bleeding time and clinical hemorrhage in myeloproliferative disease","volume":"138","author":"S Murphy","year":"1978","journal-title":"Arch Intern Med"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ajcp\/74.1.73","article-title":"Normal and abnormal bleeding times in neonates and young children utilizing a fully standardized template technic","volume":"74","author":"J H Feusner","year":"1980","journal-title":"Am J Clin Pathol"},{"issue":"01","key":"ref56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2141.1983.tb01988.x","article-title":"Acquired haemostatic defects in the ill newborn","volume":"53","author":"J H Feusner","year":"1983","journal-title":"Br J Haematol"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/adc.60.1.51","article-title":"Micromethod for bleeding time in the newborn","volume":"60","author":"J M Rennie","year":"1985","journal-title":"Arch Dis Child"},{"issue":"6484","key":"ref58","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1136\/bmj.290.6484.1767","article-title":"Shortened bleeding time in acute myocardial infarction and its relation to platelet mass","volume":"290","author":"P C Milner","year":"1985","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2141.1961.tb00318.x","article-title":"The role of red cells in haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness","volume":"7","author":"A J Hellem","year":"1961","journal-title":"Br J Haematol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000181474","article-title":"Bleeding in renal failure: altered platelet function in chronic uraemia only partially corrected by haemodialysis","volume":"22","author":"G Remuzzi","year":"1978","journal-title":"Nephron J"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1182\/blood.V58.2.326.326","article-title":"Abnormal platelet function and arachidonate metabolism in chronic idiopathic thrombocytopenic purpura","volume":"58","author":"M J Stuart","year":"1981","journal-title":"Blood"},{"issue":"06","key":"ref62","first-page":"379","article-title":"Contribution of the haematocrit to the bleeding time","volume":"13","author":"M Small","year":"1983","journal-title":"Haemostasis"},{"issue":"01","key":"ref63","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2141.1985.tb02974.x","article-title":"Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions","volume":"59","author":"F Fernandez","year":"1985","journal-title":"Br J Haematol"},{"key":"ref64","first-page":"171","volume-title":"Drugs or conditions that alter platelet function","author":"C R Hillman","year":"1981"},{"issue":"02","key":"ref65","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0002-9343(84)90707-1","article-title":"Prolonged bleeding time","volume":"77","author":"S E Lind","year":"1984","journal-title":"Am J Med"},{"issue":"14","key":"ref66","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1056\/NEJM198204083061406","article-title":"Ethanol potentiation of aspirin-induced prolongation of the bleeding time","volume":"306","author":"D Deykin","year":"1982","journal-title":"N Engl J Med"},{"key":"ref67","first-page":"121","article-title":"The Ponte Vedra syndrome \u2013 an unexpected interaction between alcohol and aspirin","volume":"93","author":"D Deykin","year":"1982","journal-title":"Trans Am Clin Climatol Assoc"},{"issue":"05","key":"ref68","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0002-8703(75)90507-4","article-title":"Effects of dipyridamole and acetylsalicylic acid on platelet functions in patients with aortic ball-valve prostheses","volume":"89","author":"J Dale","year":"1975","journal-title":"Am Heart J"},{"issue":"8387","key":"ref69","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(84)91393-X","article-title":"Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders","volume":"1","author":"N L Kobrinsky","year":"1984","journal-title":"Lancet"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1182\/blood.V67.4.1148.1148","article-title":"Controlled trial of desmopressin in liver cirrhosis and other conditions associated with a prolonged bleeding time","volume":"67","author":"P M Mannucci","year":"1986","journal-title":"Blood"},{"issue":"04","key":"ref71","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1182\/blood.V39.4.490.490","article-title":"\u201cImpotent\u201d platelets in albinos with prolonged bleeding times","volume":"39","author":"H M Maurer","year":"1972","journal-title":"Blood"},{"key":"ref72","first-page":"3217","article-title":"Sur une nouvelle vari\u00e9t\u00e9 de dystrophie thrombocytaireh\u00e9mo\u0157ragipare cong\u00e9nitale","volume":"24","author":"J Bernard","year":"1948","journal-title":"Sem Hop"},{"key":"ref73","first-page":"299","article-title":"Diagnostic etiologique des allongements du temps de saignement","volume":"3","author":"J P Soulier","year":"1963","journal-title":"Nouv Rev Fr Hematol"},{"issue":"02","key":"ref74","first-page":"144","article-title":"[Clinical trial of new bleeding time device (Simplate II) (author's transl)]","volume":"23","author":"Y Tomita","year":"1982","journal-title":"Rinsho Ketsueki"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2141.1978.tb01041.x","article-title":"Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase","volume":"38","author":"M Lagarde","year":"1978","journal-title":"Br J Haematol"},{"issue":"8174","key":"ref76","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0140-6736(80)90837-5","article-title":"Congenital deficiency of thromboxane and prostacyclin","volume":"1","author":"F I Pareti","year":"1980","journal-title":"Lancet"},{"issue":"8184","key":"ref77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0140-6736(80)92930-X","article-title":"Haemostatic balance in congenital deficiency of platelet cyclo-oxygenase","volume":"2","author":"K Rak","year":"1980","journal-title":"Lancet"},{"issue":"01","key":"ref78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajh.2830140102","article-title":"Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency","volume":"14","author":"M H Horellou","year":"1983","journal-title":"Am J Hematol"},{"issue":"06","key":"ref79","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0002-9343(74)90819-5","article-title":"Acquired \u201cstorage pool disease\u201d of platelets associated with circulating antiplatelet antibodies","volume":"56","author":"J Zahavi","year":"1974","journal-title":"Am J Med"},{"issue":"05","key":"ref80","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0002-9343(80)90436-2","article-title":"Acquired storage pool deficiency with increased platelet-associated IgG. Report of five cases","volume":"69","author":"H J Weiss","year":"1980","journal-title":"Am J Med"},{"issue":"05","key":"ref81","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1182\/blood.V57.5.856.856","article-title":"Effect of ascorbate on abnormal neutrophil, platelet and lymphocytic function in a patient with the Chediak-Higashi syndrome","volume":"57","author":"R S Weening","year":"1981","journal-title":"Blood"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.0954-6820.1961.tb00234.x","article-title":"Platelet adhesion in vivo in patients with bleeding disorders","volume":"170","author":"C F Borchgrevink","year":"1961","journal-title":"Acta Med Scand"},{"key":"ref83","first-page":"662","article-title":"Maladie de Glanzmann. 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