{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:26:07Z","timestamp":1789424767490,"version":"build-2803163510"},"reference-count":187,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, there has been a growing interest in identifying subcellular causes of male infertility, and sperm DNA fragmentation (SDF) research has been at the forefront of this focus. DNA damage can occur during spermatogenesis due to faulty chromatin compaction or excessive abortive apoptosis. It can also happen as sperm transit through the genital tract, often induced by oxidative stress. There are several methods for SDF testing, with the sperm chromatin structure assay, terminal deoxynucleotidyl transferase d-UTI nick end labeling (TUNEL) assay, comet assay, and sperm chromatin dispersion test being the most commonly used. Numerous studies strongly support the negative impact of SDF on male fertility potential. DNA damage has been linked to various morphological and functional sperm abnormalities, ultimately affecting natural conception and assisted reproductive technology outcomes. This evidence-based review aims to explore how SDF influences male reproduction and provide insights into available therapeutic options to minimize its detrimental impact.<\/jats:p>","DOI":"10.1055\/s-0043-1777324","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:04:18Z","timestamp":1702512258000},"page":"241-257","source":"Crossref","is-referenced-by-count":15,"title":["Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6637-2794","authenticated-orcid":false,"given":"Jeanett L.M.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"The Fertility Clinic, Skive Regional Hospital, Skive, Denmark"},{"name":"Department of Obstetrics and Gynecology, Viborg Regional Hospital, Viborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-6241","authenticated-orcid":false,"given":"Ahmad","family":"Majzoub","sequence":"additional","affiliation":[{"name":"Department of Urology, Hamad Medical Corporation, Doha, Qatar"},{"name":"Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-9680","authenticated-orcid":false,"given":"Sandro","family":"Esteves","sequence":"additional","affiliation":[{"name":"ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil"},{"name":"Division of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil"},{"name":"Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-5366","authenticated-orcid":false,"given":"Peter","family":"Humaidan","sequence":"additional","affiliation":[{"name":"The Fertility Clinic, Skive Regional Hospital, Skive, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"ref1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2021","edition":"6th ed."},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.rbmo.2023.04.003","article-title":"Towards infertility care on equal terms: a prime time for male infertility","volume":"47","author":"S C Esteves","year":"2023","journal-title":"Reprod Biomed 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