{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:50:02Z","timestamp":1780537802381,"version":"3.54.1"},"reference-count":90,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meningiomas are the most frequent nonmalignant tumors of the central nervous system (CNS). Despite their benign nature and slow-growing pattern, if not diagnosed early, these tumors may reach relatively large sizes causing significant morbidity and mortality. Some variants are located in hard-to-access locations, compressing critical neurovascular structures, and making the surgical management even more challenging. Although most meningiomas have a good long-term prognosis after treatment, there are still controversies over their management in a subset of cases. While surgery is the first-line treatment, the use of fractionated radiotherapy or stereotactic radiosurgery is indicated for residual or recurrent tumors, small lesions, and tumors in challenging locations. Advances in molecular genetics and ongoing clinical trial results have recently helped both to refine the diagnosis and provide hope for effective biomolecular target-based medications for treatment. This article reviews the natural history and current therapeutic options for CNS meningiomas.<\/jats:p>","DOI":"10.1055\/s-0043-1777352","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:11:31Z","timestamp":1701821491000},"page":"001-015","source":"Crossref","is-referenced-by-count":5,"title":["The Natural History and Treatment of Meningiomas: An Update"],"prefix":"10.1055","volume":"44","author":[{"given":"Arsene Daniel","family":"Nyalundja","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Center for Tropical Diseases and Global Health, Universit\u00e9 Catholique de Bukavu, Kadutu, Bukavu, South Kivu, Democratic Republique of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Mugisha","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Surgery, Rwanda Military Hospital, Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-899X","authenticated-orcid":false,"given":"Claire","family":"Karekezi","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Surgery, Rwanda Military Hospital, Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/B978-1-4160-5654-6.00003-9","volume-title":"The origin of meningiomas","author":"S B Albayrak","year":"2010"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/neuonc\/nov069","article-title":"Descriptive epidemiology of World Health Organization grades II and III intracranial meningiomas in the United States","volume":"17","author":"V R Kshettry","year":"2015","journal-title":"Neuro-oncol"},{"issue":"S 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