{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:44:49Z","timestamp":1740109489794,"version":"3.37.3"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Angiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Objective\u2003Chronic limb-threatening ischemia (CLTI) is associated with high morbidity and mortality. Classification methods differentiate into patients with rest pain or with ischemic ulcers. No distinction is made between the presence or absence of rest pain in patients with ischemic ulcers. Our aim is to determine any differences in outcome between these subdivisions so we can improve preoperative counseling and risk assessment.<\/jats:p><jats:p>\n               Materials and Methods\u2003This multicenter retrospective cohort study included all patients revascularized for a first episode of CLTI between 2013 and 2018. The cohort was divided in three groups: patients with solely rest pain (RP), solely ischemic ulcers (IU), and patients with both rest pain and ischemic ulcers (RP\u2009+\u2009IU). Baseline characteristics, morbidity, and mortality were analyzed.<\/jats:p><jats:p>\n               Results\u2003A total of 624 limbs in 599 patients were included: 225 (36.1%) in the rest pain group, 169 (27.1%) in the ischemic ulcers group, and 230 (36.2%) in combined group. Amputation rates were higher in the combined group at 6 months. Mortality rates were significantly higher in the ischemic ulcers group and the combined group at 6 months and 1 year.<\/jats:p><jats:p>\n               Conclusion\u2003Patients with solely rest pain have significantly lower mortality rates in comparison to patients with ischemic ulcers. Rest pain did not affect mortality rates in patients with ulcers. There was a higher amputation rate in patients with combined rest pain and ischemic ulcers because the presence of rest pain CLTI patients had a significant negative effect on amputation risk. A separate subdivision for patients with combined ulcers and rest pain is indicated.<\/jats:p>","DOI":"10.1055\/s-0043-1777414","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:29Z","timestamp":1702684829000},"page":"008-014","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Limb-Threatening Ischemia does not Enclose a Homogenous Population: Time for a More Detailed Classification"],"prefix":"10.1055","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7982-4349","authenticated-orcid":false,"given":"Schraepen","family":"C\u00e9dric","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"van der Laan","family":"Lijckle","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Surgery, Amphia Hospital, Breda, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-4374","authenticated-orcid":false,"given":"Smet","family":"Nick","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Surgery, Amphia Hospital, Breda, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meulenbroek","family":"Anne","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Surgery, Amphia Hospital, Breda, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fourneau","family":"Inge","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2006.09.024","article-title":"Inter-Society Consensus for the management of peripheral arterial disease (TASC II)","volume":"33","author":"L Norgren","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/VHRM.S209241","article-title":"The burden of critical limb ischemia: a review of recent literature","volume":"15","author":"S Duff","year":"2019","journal-title":"Vasc Health Risk Manag"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejvs.2017.07.005","article-title":"Amputation rates, mortality, and pre-operative comorbidities in patients revascularised for intermittent claudication or critical limb ischaemia: a population based 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Thromb Vasc Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijsu.2016.09.001","article-title":"Risk factors of post-operative delirium after elective vascular surgery in the elderly: a systematic review","volume":"35","author":"J W Raats","year":"2016","journal-title":"Int J Surg"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2147\/CIA.S357812","article-title":"Multicomponent prehabilitation as a novel strategy for preventing delirium in older chronic limb threatening ischemia patients: a study protocol","volume":"17","author":"A L Meulenbroek","year":"2022","journal-title":"Clin Interv Aging"}],"container-title":["International Journal of Angiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1777414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:35:35Z","timestamp":1730810135000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1777414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":11,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1777414","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1061-1711","1615-5939"],"issn-type":[{"type":"print","value":"1061-1711"},{"type":"electronic","value":"1615-5939"}],"subject":[],"published":{"date-parts":[[2023,12,15]]}}}