{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:09:38Z","timestamp":1778260178285,"version":"3.51.4"},"reference-count":53,"publisher":"Georg Thieme Verlag KG","issue":"03\/04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity affects nearly 40% of reproductive-aged women and has serious implications for women's overall and reproductive health. Women with an elevated body mass index (BMI) have higher rates of anovulation and irregular menses, lower success with fertility treatment, and significantly higher rates of pregnancy complications, such as hypertension\/preeclampsia, gestational diabetes, and preterm delivery. Many studies have also shown an association between obesity and early pregnancy loss. However, the causal association between BMI and miscarriage has not been elucidated, likely due to the multifactorial effects that BMI may have on early pregnancy development. In addition, BMI as an isolated variable fails to capture other relevant confounding health risk factors, such as nutrition, physical activity, and insulin resistance. In this review, we will summarize the current literature demonstrating the association between BMI and miscarriage, highlight the research that attempts to explain the association, and finally provide data on therapeutic interventions to improve reproductive outcomes in women suffering from obesity and early pregnancy loss.<\/jats:p>","DOI":"10.1055\/s-0043-1777759","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:01:51Z","timestamp":1702684911000},"page":"80-86","source":"Crossref","is-referenced-by-count":10,"title":["Obesity and Miscarriage"],"prefix":"10.1055","volume":"41","author":[{"given":"Samantha","family":"McLean","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina E.","family":"Boots","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"issue":"360","key":"ref1","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017-2018","author":"C M Hales","year":"2020","journal-title":"NCHS Data Brief"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/AOG.0000000000004527","article-title":"Obesity in pregnancy: ACOG Practice Bulletin, Number 230","volume":"138","author":"L Sagi-Dain","year":"2021","journal-title":"Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2419263","DOI":"10.1155\/2019\/2419263","article-title":"Marked Disparities in pre-pregnancy obesity and overweight prevalence among US women by race\/ethnicity, nativity\/immigrant status, and sociodemographic characteristics, 2012-2014","volume":"2019","author":"G K Singh","year":"2019","journal-title":"J Obes"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.fertnstert.2021.08.018","article-title":"Obesity and reproduction: a committee opinion","volume":"116","author":"Practice Committee of the American Society for Reproductive Medicine. 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