{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:25:30Z","timestamp":1730870730444,"version":"3.28.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Wuhan Health Commission Project","award":["WX21B06"],"award-info":[{"award-number":["WX21B06"]}]},{"name":"Hubei Provincial Science and Technology Plan Project","award":["2022DCC020"],"award-info":[{"award-number":["2022DCC020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The risk factors for respiratory insufficiency in children with Guillain\u2013Barr\u00e9 syndrome (GBS) are poorly known. This study aimed to investigate the factors associated with respiratory insufficiency in children with GBS.<\/jats:p><jats:p>\n          Methods\u2003This retrospective study included children diagnosed with GBS by pediatric neurologists and admitted at the Wuhan Children's Hospital and other hospitals from January 2013 to October 2022. The patients were divided into the respiratory insufficiency and nonrespiratory insufficiency groups according to whether they received assist breathing during treatment.<\/jats:p><jats:p>\n          Results\u2003The median (interquartile range) age of onset of 103 patients were 5 (3.1\u20138.5) years, 69 (67%) were male, and 64 (62.1%) had a history of precursor infection. Compared with the nonrespiratory insufficiency group, the respiratory insufficiency group showed more facial and\/or bulbar weakness (p\u2009=\u20090.002), a higher Hughes Functional Grading Scale (HFGS) at admission (p\u2009&lt;\u20090.001), and a shorter onset-to-admission interval (p\u2009=\u20090.017). Compared with the acute motor axonal neuropathy (AMAN) subtype, the acute inflammatory demyelinating polyneuropathy (AIDP) subtype showed longer days from onset to lumbar (p\u2009=\u20090.000), lower HFGS at admission (p\u2009=\u20090.04), longer onset-to-admission interval (p\u2009=\u20090.001), and more cranial nerve involvement (p\u2009=\u20090.04). The incidence of respiratory insufficiency between AIDP and AMAN showed no statistical difference (p\u2009&gt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003In conclusion, facial and\/or bulbar weakness, HFGS at admission, and onset-to-admission interval were associated with respiratory insufficiency and might be useful prognostic markers in children with GBS.<\/jats:p>","DOI":"10.1055\/s-0043-1777767","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:05:05Z","timestamp":1705968305000},"page":"112-116","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Respiratory Insufficiency in Children with Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1055","volume":"55","author":[{"given":"Rui-di","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Wuhan Children's Hospital (Wuhan Maternal and Children's Healthcare Center), Wuhan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Wuhan Children's Hospital (Wuhan Maternal and Children's Healthcare Center), Wuhan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-long","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Wuhan Children's Hospital (Wuhan Maternal and Children's Healthcare Center), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref1","first-page":"1295","article-title":"Guillain-Barr\u00e9 syndrome","volume":"23","author":"P D Donofrio","year":"2017","journal-title":"Continuum (Minneap Minn)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"388","author":"H J Willison","year":"2016","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(21)00517-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"397","author":"N Shahrizaila","year":"2021","journal-title":"Lancet"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archneur.58.6.913","article-title":"Early electrodiagnostic findings in Guillain-Barr\u00e9 syndrome","volume":"58","author":"P H Gordon","year":"2001","journal-title":"Arch Neurol"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.clinph.2004.05.009","article-title":"Neurophysiologic findings in early acute inflammatory demyelinating polyradiculoneuropathy","volume":"115","author":"S Vucic","year":"2004","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00381-018-3856-0","article-title":"Guillain-Barr\u00e9 syndrome in children: subtypes and outcome","volume":"34","author":"Z S Karalok","year":"2018","journal-title":"Childs Nerv Syst"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.4187\/respcare.10311","article-title":"2021 year in review: pediatric mechanical ventilation","volume":"67","author":"A G Miller","year":"2022","journal-title":"Respir Care"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.17219\/acem\/37264","article-title":"Mechanical ventilation in children - problems and issues. 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