{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:20:06Z","timestamp":1778858406618,"version":"3.51.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Lotterywest","award":["107\/20090827"],"award-info":[{"award-number":["107\/20090827"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003To evaluate the associations between sleep quality and serum levels of neurofilament light (NfL) protein in individuals with premanifest Huntington disease (HD).<\/jats:p><jats:p>\n          Materials and Methods\u2003We recruited 28 individuals with premanifest HD from a pre-existing database (of the Huntington's Environmental Research Optimisation Scheme, HEROs). The participants filled out the Pittsburgh Sleep Quality Index (PSQI), a subjective measure of sleep quality, and blood was collected via routine venepuncture to measure peripheral NfL levels.<\/jats:p><jats:p>\n          Results\u2003The PSQI scores (median: 5.0; interquartile range: 4.0\u20137.5) indicated poor sleep quality. General linear modelling revealed no significant (p\u2009=\u20090.242) association between PSQI scores and NfL levels. No significant differences were found between individuals with good and poor sleep quality for any demographic variable collected.<\/jats:p><jats:p>\n          Discussion\u2003Contrary to studies on other neurological conditions, there was no association between sleep quality and NfL levels in individuals with premanifest HD. This was unexpected, given the influence of environmental factors (such as social network size) on neurodegeneration in individuals with premanifest HD.<\/jats:p>","DOI":"10.1055\/s-0043-1777783","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T23:57:20Z","timestamp":1708041440000},"page":"e199-e202","source":"Crossref","is-referenced-by-count":2,"title":["Associations between Sleep Quality and Serum Levels of Neurofilament Light in Individuals with Premanifest Huntington Disease"],"prefix":"10.1055","volume":"17","author":[{"given":"Mitchell","family":"Turner","sequence":"additional","affiliation":[{"name":"Centre for Precision Health, Edith Cowan University, Perth, WA, Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-3760","authenticated-orcid":false,"given":"Danielle","family":"Bartlett","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govinda","family":"Poudel","sequence":"additional","affiliation":[{"name":"Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Zaenker","sequence":"additional","affiliation":[{"name":"Centre for Precision Health, Edith Cowan University, Perth, WA, Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Laws","sequence":"additional","affiliation":[{"name":"Centre for Precision Health, Edith Cowan University, Perth, WA, Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Lo","sequence":"additional","affiliation":[{"name":"School of Science, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mel","family":"Ziman","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Cruickshank","sequence":"additional","affiliation":[{"name":"Centre for Precision Health, Edith Cowan University, Perth, WA, Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia"},{"name":"Perron Institute for Neurological and Translational Sciences, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"RRN1189","DOI":"10.1371\/currents.RRN1189","article-title":"Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire","volume":"2","author":"A O Goodman","year":"2010","journal-title":"PLoS Curr"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.24495","article-title":"Sleep deficits but no metabolic deficits in premanifest Huntington's disease","volume":"78","author":"A S Lazar","year":"2015","journal-title":"Ann Neurol"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.sleep.2014.12.021","article-title":"Nocturnal agitation in Huntington disease is caused by arousal-related abnormal movements rather than by rapid eye movement sleep behavior disorder","volume":"16","author":"D Neutel","year":"2015","journal-title":"Sleep Med"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11910-010-0163-x","article-title":"Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease","volume":"11","author":"A O Goodman","year":"2011","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000480701","article-title":"Subjective assessment of sleep in Huntington disease: reliability of sleep questionnaires compared to polysomnography","volume":"17","author":"C Piano","year":"2017","journal-title":"Neurodegener Dis"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/jpm12060864","article-title":"Sleep Quality and Related Clinical Manifestations in Huntington Disease","volume":"12","author":"S Maffi","year":"2022","journal-title":"J Pers Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jns.2016.03.021","article-title":"Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function","volume":"364","author":"C R Baker","year":"2016","journal-title":"J Neurol Sci"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"zsaa147","DOI":"10.1093\/sleep\/zsaa147","article-title":"Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease","volume":"44","author":"A Targa","year":"2021","journal-title":"Sleep"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"zsaa272","DOI":"10.1093\/sleep\/zsaa272","article-title":"Poor sleep correlates with biomarkers of neurodegeneration in mild traumatic brain injury patients: a CENC study","volume":"44","author":"J K Werner Jr","year":"2021","journal-title":"Sleep"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.sleep.2017.12.012","article-title":"Patients with chronic insomnia disorder have increased serum levels of neurofilaments, neuron-specific enolase and S100B: does organic brain damage exist?","volume":"48","author":"P Zhang","year":"2018","journal-title":"Sleep Med"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/JHD-200434","article-title":"Sleep dysfunction in Huntington's disease: perspectives from patients","volume":"9","author":"W K Tanigaki","year":"2020","journal-title":"J Huntingtons Dis"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/JHD-180291","article-title":"Circadian rhythm, cognition, and mood disorders in Huntington's disease","volume":"7","author":"E B Diago","year":"2018","journal-title":"J Huntingtons Dis"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"e01578","DOI":"10.1002\/brb3.1578","article-title":"The relationship between lifestyle and serum neurofilament light protein in Huntington's disease","volume":"10","author":"T Cruickshank","year":"2020","journal-title":"Brain Behav"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.3390\/ijerph18105113","article-title":"Genetic and Environmental Contributors to Neurodegeneration: An Exploration of the Effects of Alcohol on Clinical Features of Huntington's Disease Using the Enroll-HD Global Platform","volume":"18","author":"A L Symonds","year":"2021","journal-title":"Int J Environ Res Public Health"}],"container-title":["Sleep 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