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Indeed, the treatment of idiopathic male infertility is based on an empirical approach that involves administration of the follicle-stimulating hormone (FSH) in dosages within the replacement therapy range. This treatment has so far been attempted when the endogenous FSH serum levels are within the reference ranges. According to the most recent evidence, a \u201csubstitutive\u201d FSH administration may not be effective enough, while a stimulatory approach could boost spermatogenesis over its basal levels without adverse extragonadal effects. This article aims to describe the rationale behind the empirical application of gonadotropins in couple infertility, highlighting the need for a change in the therapeutic approach, especially for the male partner.<\/jats:p>","DOI":"10.1055\/s-0043-1777837","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:20:22Z","timestamp":1703895622000},"page":"258-266","source":"Crossref","is-referenced-by-count":3,"title":["Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy"],"prefix":"10.1055","volume":"41","author":[{"given":"Marilina","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Donno","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Spaggiari","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio R.M.","family":"Granata","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Simoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"La Marca","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-7105","authenticated-orcid":false,"given":"Daniele","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"},{"name":"Department of Medical Specialties, Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/GRH.0000000000000052","article-title":"WHO fact sheet on infertility","volume":"6","year":"2021","journal-title":"Glob Reprod Health"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fertnstert.2021.12.012","article-title":"The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: ensuring quality and standardization in basic examination of human ejaculates","volume":"117","author":"L Bj\u00f6rndahl","year":"2022","journal-title":"Fertil Steril"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1210\/jc.2012-2400","article-title":"Approach to male infertility and induction of spermatogenesis","volume":"98","author":"B D Anawalt","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/cells9040990","article-title":"Male infertility is a women's health issue - 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