{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:02:23Z","timestamp":1769504543225,"version":"3.49.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Skin grafting plays a vital role in post-burn and post-traumatic wound management. Split-thickness skin grafts (STSG) are traditionally fixed using staples or sutures, which have tedious application and their removal necessitates painkillers, medical equipment, and human intervention. As an alternative, fibrin sealant is a biological tissue adhesive, composed of thrombin, calcium, and fibrinogen. Fibrin sealant promotes hemostasis and acts as a biological adherent.<\/jats:p><jats:p>\n          Objective\u2003The aim of this study was to evaluate the outcomes (graft take, wound healing and complications) of fibrin sealant and staples for STSG fixation.<\/jats:p><jats:p>\n          Methods\u2003It is a randomized controlled trial on 40 patients with wounds of minimum 400\u2009cm2. Wound area was divided into equal halves and randomly allocated to the study group or control group. In the study group, 4\u2009mL per 200\u2009cm2 of fibrin sealant was sprayed followed by STSG application. In the control group, STSG was fixed with only skin staples. Evaluation was done on postoperative days 3, 5, 15, and 30 for graft take, hematoma\/seroma, infection, and complete wound healing.<\/jats:p><jats:p>\n          Results\u2003The mean graft take was significantly higher (p-value\u2009&lt;\u20090.05) in the study group than in the control group (91 vs. 89%). No seroma or hematoma formation was seen in either group. Complete wound healing was seen in more patients in the study group, but the difference was statistically insignificant.<\/jats:p><jats:p>\n          Conclusion\u2003Fibrin sealant is an excellent alternative to staples for skin grafting, with the advantage of better graft take and being free of pain that is incurred during staple removal.<\/jats:p>","DOI":"10.1055\/s-0043-1777867","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:08:40Z","timestamp":1704499720000},"page":"060-066","source":"Crossref","is-referenced-by-count":3,"title":["An Outcome Analysis of Fibrin Sealant versus Staples for Fixation of Split-Thickness Skin Grafts"],"prefix":"10.1055","volume":"57","author":[{"given":"Akshara","family":"Shuchi","sequence":"additional","affiliation":[{"name":"Department of Burns, Plastic and Maxillofacial Surgery, VMMC and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-4074","authenticated-orcid":false,"given":"Deepti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Burns, Plastic and Maxillofacial Surgery, VMMC and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujata","family":"Sarabahi","sequence":"additional","affiliation":[{"name":"Department of Burns, Plastic and Maxillofacial Surgery, VMMC and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/00006534-199703000-00034","article-title":"The use of fibrin sealant in the prevention of seromas","volume":"99","author":"D A Kulber","year":"1997","journal-title":"Plast Reconstr 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Grunzweig","year":"2019","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1055\/s-0029-1201395","article-title":"Uber Wirkungen des Fibrins","volume":"35","author":"S Bergel","year":"1909","journal-title":"Dtsch Med Wochenschr"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/SAP.0000000000000397","article-title":"Cost-benefit analysis of outcomes from the use of fibrin sealant for fixation of skin grafts in small-size burns compared to staples as historical controls: a retrospective review","volume":"74","author":"C C Butts","year":"2015","journal-title":"Ann Plast Surg"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/ijb.ijb_30_16","article-title":"Impact of nonscraping of granulation tissue on outcomes after skin grafting","volume":"25","author":"D Krishna","year":"2017","journal-title":"Indian J 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