{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:22Z","timestamp":1792176442204,"version":"4.4.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HD096798"],"award-info":[{"award-number":["R01HD096798"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n            Objective\u2003To pilot measurement of hair cortisol concentration (HCC) in pregnant women with opioid use disorder and their infants over time and study the potential utility of hair cortisol as a biomarker of chronic stress in this population.<\/jats:p><jats:p>\n            Study Design\u2003In this pilot prospective cohort study of mother\u2013infant dyads with and without prenatal opioid exposure, we obtained mother\u2013infant HCCs at delivery and again within 1 to 3 months' postpartum. HCCs were compared between the opioid and control groups and between the two time points.<\/jats:p><jats:p>\n            Results\u2003There were no significant differences between opioid and control group maternal or infant HCCs at either time point. However, within the opioid-exposed group, there was a significant increase in infant HCCs across the two time points.<\/jats:p><jats:p>\n            Conclusion\u2003This pilot study describes our experience with the measurement of HCCs in opioid-exposed mother\u2013infant dyads.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1778008","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T23:30:46Z","timestamp":1704065446000},"page":"1106-1112","source":"Crossref","is-referenced-by-count":2,"title":["Hair Cortisol Concentrations in Opioid-Exposed versus Nonexposed Mother\u2013Infant Dyads"],"prefix":"10.1055","volume":"41","author":[{"given":"Tierney M.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida M.","family":"Schiff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigael","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Boston University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Massachusetts Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Work","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serra","family":"Muftu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Boateng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Werler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginny","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendree E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisha M.","family":"Wachman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.ctdb.2016.12.004","article-title":"Mechanisms of glucocorticoid action during development","volume":"125","author":"J T Busada","year":"2017","journal-title":"Curr Top Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/bs.irn.2019.11.002","article-title":"Prenatal stress: effects on fetal and child brain development","volume":"150","author":"A Lautarescu","year":"2020","journal-title":"Int Rev Neurobiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"106030","DOI":"10.1016\/j.addbeh.2019.106030","article-title":"Pregnant women in treatment for opioid use disorder: material hardships and psychosocial factors","volume":"98","author":"R Rose-Jacobs","year":"2019","journal-title":"Addict Behav"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ynstr.2018.08.005","article-title":"Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure","volume":"9","author":"E Conradt","year":"2018","journal-title":"Neurobiol Stress"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"e12786","DOI":"10.1111\/jne.12786","article-title":"Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling","volume":"32","author":"A L Franks","year":"2020","journal-title":"J Neuroendocrinol"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000354702","article-title":"Changes in the maternal hypothalamic-pituitary-adrenal axis in pregnancy and postpartum: influences on maternal and fetal outcomes","volume":"98","author":"L Duthie","year":"2013","journal-title":"Neuroendocrinology"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000100085","article-title":"Hair cortisol as a potential biologic marker of chronic stress in hospitalized neonates","volume":"92","author":"J Yamada","year":"2007","journal-title":"Neonatology"},{"issue":"02","key":"ref8","first-page":"81","article-title":"Hair cortisol concentration as a biomarker of sleep quality and related disorders","volume":"11","author":"N El Mlili","year":"2021","journal-title":"Life (Basel)"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.physbeh.2011.02.041","article-title":"Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol","volume":"104","author":"K L D'Anna-Hernandez","year":"2011","journal-title":"Physiol Behav"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.25011\/cim.v30i2.986","article-title":"The relationship between stress and hair cortisol in healthy pregnant women","volume":"30","author":"S Kalra","year":"2007","journal-title":"Clin Invest Med"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/dev.21394","article-title":"Intra-individual stability and developmental change in hair cortisol among postpartum mothers and infants: implications for understanding chronic stress","volume":"58","author":"C H Liu","year":"2016","journal-title":"Dev Psychobiol"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/dev.21896","article-title":"Maternal hair cortisol levels as a novel predictor of neonatal abstinence syndrome severity: a pilot feasibility study","volume":"62","author":"E M Wachman","year":"2020","journal-title":"Dev Psychobiol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/dev.21433","article-title":"Cortisol during human fetal life: characterization of a method for processing small quantities of newborn hair from 26 to 42 weeks gestation","volume":"59","author":"M C Hoffman","year":"2017","journal-title":"Dev Psychobiol"},{"issue":"08","key":"ref14","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41372-018-0109-8","article-title":"Quality improvement initiative to improve inpatient outcomes for neonatal abstinence syndrome","volume":"38","author":"E M Wachman","year":"2018","journal-title":"J Perinatol"},{"issue":"09","key":"ref15","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1210\/en.2012-1226","article-title":"Minireview: hair cortisol: a novel biomarker of hypothalamic-pituitary-adrenocortical activity","volume":"153","author":"J S Meyer","year":"2012","journal-title":"Endocrinology"},{"issue":"83","key":"ref16","first-page":"e50882","article-title":"Extraction and analysis of cortisol from human and monkey hair","volume":"e50882","author":"J Meyer","year":"2014","journal-title":"J Vis Exp"},{"key":"ref17","first-page":"43","volume-title":"Introduction to Data Analysis","author":"L Metcalf","year":"2016"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"e782","DOI":"10.1210\/clinem\/dgz313","article-title":"Maternal glucocorticoid metabolism across pregnancy: a potential mechanism underlying fetal glucocorticoid exposure","volume":"105","author":"D Q Stoye","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/er.2008-0014","article-title":"Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review","volume":"30","author":"M Tegethoff","year":"2009","journal-title":"Endocr Rev"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1037\/0033-2909.133.1.25","article-title":"If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans","volume":"133","author":"G E Miller","year":"2007","journal-title":"Psychol Bull"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/dev.21302","article-title":"Hair cortisol concentrations in higher- and lower-stress mother-daughter dyads: a pilot study of associations and moderators","volume":"57","author":"S J Ouellette","year":"2015","journal-title":"Dev Psychobiol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/ADM.0000000000000092","article-title":"Methadone and buprenorphine for opioid dependence during pregnancy: a retrospective cohort study","volume":"9","author":"M C Meyer","year":"2015","journal-title":"J Addict Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1778008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:44:42Z","timestamp":1730814282000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1778008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,31]]},"references-count":22,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,5,20]]},"published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1778008","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,31]]}}}