{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:16:06Z","timestamp":1788232566837,"version":"build-2803163510"},"reference-count":118,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The microbiome of the female upper reproductive system has garnered increasing recognition and has become an area of interest in the study of women's health. This intricate ecosystem encompasses a diverse consortium of microorganisms (i.e., microbiota) and their genomes (i.e., microbiome) residing in the female upper reproductive system, including the uterus, the fallopian tubes, and ovaries. In recent years, remarkable advancements have been witnessed in sequencing technologies and microbiome research, indicating the potential importance of the microbial composition within these anatomical sites and its impact in women's reproductive health and overall well-being. Understanding the composition, dynamics, and functions of the microbiome of the female upper reproductive system opens up exciting avenues for improving fertility, treating gynecological conditions, and advancing our comprehension of the intricate interplay between the microbiome and the female reproductive system. The aim of this study is to compile currently available information on the microbial composition of the female upper reproductive system in humans, with a focus beyond the uterus, which has received more attention in recent microbiome studies compared with the fallopian tubes and ovaries. In conclusion, this review underscores the potential role of this microbiome in women's physiology, both in health and disease.<\/jats:p>","DOI":"10.1055\/s-0043-1778056","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T23:44:22Z","timestamp":1707263062000},"page":"190-199","source":"Crossref","is-referenced-by-count":6,"title":["The Upper Reproductive System Microbiome: Evidence beyond the Uterus"],"prefix":"10.1055","volume":"41","author":[{"given":"Analuce","family":"Canha-Gouveia","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary, University of Murcia, Murcia, Spain"},{"name":"Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital \u201cVirgen de la Arrixaca,\u201d Murcia, Spain"},{"name":"Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Nisio","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden"},{"name":"Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Salumets","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden"},{"name":"Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden"},{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia"},{"name":"Competence Centre on Health Technologies, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauliina","family":"Damdimopoulou","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden"},{"name":"Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Coy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary, University of Murcia, Murcia, Spain"},{"name":"Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital \u201cVirgen de la Arrixaca,\u201d Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Altm\u00e4e","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden"},{"name":"Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Sola-Leyva","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden"},{"name":"Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden"},{"name":"Competence Centre on Health Technologies, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref1","volume-title":"Physiology, Female Reproduction","author":"J Rosner","year":"2022"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1177\/1933719117698577","article-title":"Reproductive microbiomes: a new thread in the microbial network","volume":"24","author":"M L Power","year":"2017","journal-title":"Reprod Sci"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","article-title":"Are we really vastly outnumbered? 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