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Recent efforts, therefore, combine several parameters into screening algorithms, to increase diagnostic accuracy. Besides patient selection, for example, by specific characteristics, algorithms include nonpatented or patented blood tests and liver stiffness measurements using elastography-based techniques. Algorithms can be composed as a set of sequential tests, as recommended by most guidelines on primary care pathways. Future use of algorithms that are easy to interpret, cheap, and semiautomatic will improve the management of patients with SLD, to the benefit of global health care systems.<\/jats:p>","DOI":"10.1055\/s-0043-1778127","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T23:52:15Z","timestamp":1706053935000},"page":"023-034","source":"Crossref","is-referenced-by-count":4,"title":["Algorithms for Early Detection of Silent Liver Fibrosis in the Primary Care Setting"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-0689","authenticated-orcid":false,"given":"Katrine Tholstrup","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-7706","authenticated-orcid":false,"given":"Katrine Prier","family":"Lindvig","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-1924","authenticated-orcid":false,"given":"Maja","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-8588","authenticated-orcid":false,"given":"Laurent","family":"Castera","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital Beaujon, Clichy, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, UMR1149 (CRI), INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","article-title":"Global epidemiology of cirrhosis\u2014aetiology, trends and predictions","volume":"20","author":"D Q Huang","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"H Devarbhavi","year":"2023","journal-title":"J Hepatol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.32163","article-title":"Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases","volume":"75","author":"P Gin\u00e8s","year":"2022","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(21)01701-3","article-title":"The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality","volume":"399","author":"T H Karlsen","year":"2022","journal-title":"Lancet"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"M E Rinella","year":"2023","journal-title":"J Hepatol"},{"issue":"04","key":"ref6","first-page":"281","article-title":"[Principles and practice of mass screening for disease]","volume":"65","author":"J MG Wilson","year":"1968","journal-title":"Bol Oficina Sanit Panam"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1001\/jama.2012.186","article-title":"Does this patient with liver disease have cirrhosis?","volume":"307","author":"J A Udell","year":"2012","journal-title":"JAMA"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1080\/00365521.2021.1929450","article-title":"Diagnostic accuracy of routine liver function tests to identify patients with significant and advanced alcohol-related liver fibrosis","volume":"56","author":"K P Lindvig","year":"2021","journal-title":"Scand J Gastroenterol"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","article-title":"EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update","volume":"75","author":"European Association for the Study of the Liver. 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