{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:24:06Z","timestamp":1787505846918,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Objective\u2003This study evaluated the effects of receiving glucose feedback from continuous glucose monitoring (CGM) by intermittent scanning (unblinded group), and CGM with masked feedback (blinded group) in the subsequent development of gestational diabetes mellitus (GDM).<\/jats:p>\n                  <jats:p>Study Design\u2003This was a prospective, single-center, pilot, randomized controlled trial including n\u2009=\u2009206 pregnant women in the first trimester of pregnancy with no prior diagnosis of type 1 or type 2 diabetes. The participants were randomized into the unblinded group or blinded group and wore the CGM in the first trimester of pregnancy (9\u201313 weeks), the second trimester of pregnancy (18\u201323 weeks), and late-second to early-third trimester (24\u201331 weeks). The primary outcome was GDM rate as diagnosed by the 75-g oral glucose tolerance test (OGTT) at 24 to 28 weeks.<\/jats:p>\n                  <jats:p>Results\u2003Over 47 months, 206 pregnant women were enrolled at 9 to 13 weeks. The unblinded group had a higher prevalence of women who developed GDM (21.5 vs. 14.9%; p\u2009&gt;\u20090.05), compared to the blinded group. In the unblinded group compared to the blinded group, plasma glucose values were higher at 1\u2009hour (median 7.7 [interquartile range {IQR}: 6.3\u20139.2] vs. 7.5 [6.3\u20138.7]) and 2\u2009hours (6.3 [5.8\u20137.7] vs. 6.2 [5.3\u20137.2]), but lower at 0\u2009hour (4.2 [4.0\u20134.5] vs. 4.3 [4.1\u20134.6]; p\u2009&gt;\u20090.05). All these differences were not statistically significant.<\/jats:p>\n                  <jats:p>Conclusion\u2003Glucose feedback from CGM wear in the first to the third trimester of pregnancy without personalized patient education failed to alter GDM rate.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0043-1778664","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T18:45:07Z","timestamp":1705689907000},"page":"e3374-e3382","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Continuous Glucose Monitoring Feedback in the Subsequent Development of Gestational Diabetes: A Pilot, Randomized, Controlled Trial in Pregnant Women"],"prefix":"10.1055","volume":"41","author":[{"given":"Phaik Ling","family":"Quah","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay Kok","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngee","family":"Lek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, KK Women's and Children's Hospital, Singapore"},{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shephali","family":"Tagore","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard Su Min","family":"Chern","sequence":"additional","affiliation":[{"name":"Minimally Invasive Surgery Unit, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng Bin","family":"Ang","sequence":"additional","affiliation":[{"name":"Family Medicine Service\/Menopause Unit, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serene Pei Ting","family":"Thain","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Hian","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore"},{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2147\/DMSO.S261486","article-title":"A review of research progress on glycemic variability and gestational diabetes","volume":"13","author":"W Yu","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12020-012-9753-5","article-title":"Glycemic variability in gestational diabetes mellitus and its association with \u03b2 cell function","volume":"43","author":"J B Su","year":"2013","journal-title":"Endocrine"},{"issue":"S 04","key":"ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/1471-0528.15849","article-title":"Comparative analysis of 2-week glycaemic profile of healthy versus mild gestational diabetic pregnant women using flash glucose monitoring system: an observational study","volume":"126","author":"A Nigam","year":"2019","journal-title":"BJOG"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/dia.2010.0145","article-title":"Glucose variability in diabetic pregnancy","volume":"13","author":"M G Dalfr\u00e0","year":"2011","journal-title":"Diabetes Technol Ther"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12933-020-01085-6","article-title":"Glycemic variability: adverse clinical outcomes and how to improve it?","volume":"19","author":"Z Zhou","year":"2020","journal-title":"Cardiovasc Diabetol"},{"issue":"S 01","key":"ref6","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.2337\/dc21-S014","article-title":"14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021","volume":"44","author":"American Diabetes Association","year":"2021","journal-title":"Diabetes Care"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2337\/cd20-0043","article-title":"Using continuous glucose monitoring in clinical practice","volume":"38","author":"E M Miller","year":"2020","journal-title":"Clin Diabetes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fendo.2019.00697","article-title":"Application and utility of continuous glucose monitoring in pregnancy: a systematic review","volume":"10","author":"Q Yu","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"a1680","DOI":"10.1136\/bmj.a1680","article-title":"Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial","volume":"337","author":"H R 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