{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:59:28Z","timestamp":1788865168158,"version":"build-2803163510"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Carduus marianus is a Mediterranean plant used for treating liver diseases. One of its properties is that it inhibits fat peroxidation, which can contribute toward the prevention of metabolites that are harmful to the liver.<\/jats:p><jats:p>\n          Objective\u2003The aim of this study was to describe the treatment of fatty liver disease in an axolotl (Ambystoma mexicanum).<\/jats:p><jats:p>\n          Methods\u2003An approximately 6-year-old female specimen of A. mexicanum, of length 21\u2009cm and weight 153\u2009g, presented edema in the rostral region and inappetence. Ultrasound showed hepatopathy and a gallbladder stone. A globule of C. marianus 6cH was diluted in 30 mL distilled water and administered in spray form over the animal twice a day.<\/jats:p><jats:p>\n          Results\u2003Twenty days after the beginning of the treatment, improvement of the facial edema and return of appetite were observed. Ultrasound showed improvement in the appearance of the liver and reduction in the size of the gallstone. The Modified Naranjo Criteria for Homeopathy score was +9 in this case, thus suggesting a causal relationship between the use of homeopathic medicine and the clinical outcome.<\/jats:p><jats:p>\n          Conclusion\u2003C. marianus 6cH appeared to be effective in treating fatty liver disease and gallstone in this specimen of A. mexicanum.\n        <\/jats:p>","DOI":"10.1055\/s-0043-1778686","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T23:52:02Z","timestamp":1709250722000},"page":"058-061","source":"Crossref","is-referenced-by-count":2,"title":["Action of Carduus marianus 6cH on Hepatopathy and Gallstone in Ambystoma mexicanum (Axolotl): Case Report"],"prefix":"10.1055","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-9958","authenticated-orcid":false,"given":"J\u00e9ssica Am\u00e2ncio","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade de Santo Amaro, S\u00e3o Paulo\u2014SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-6315","authenticated-orcid":false,"given":"Melina Castilho de Souza","family":"Balbueno","sequence":"additional","affiliation":[{"name":"Universidade de Santo Amaro, HD Science, S\u00e3o Paulo\u2014SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-1822","authenticated-orcid":false,"given":"Cid\u00e9li de Paula","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade de Santo Amaro, HD Science, S\u00e3o Paulo\u2014SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2014.09.021","article-title":"Co-operative Bmp- and Fgf-signaling inputs convert skin wound healing to limb formation in urodele 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Narita","year":"2020","journal-title":"Homeopathy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0040-1701251","article-title":"Evaluation of the modified Naranjo criteria for assessing causal attribution of clinical outcome to homeopathic intervention as presented in case reports","volume":"109","author":"C D Lamba","year":"2020","journal-title":"Homeopathy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ctim.2015.12.019","article-title":"Homeopathic clinical case reports: development of a supplement (HOM-CASE) to the CARE clinical case reporting guideline","volume":"25","author":"R A van Haselen","year":"2016","journal-title":"Complement Ther Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jes.2015.06.020","article-title":"Liver histological changes and lipid peroxidation in the amphibian Ambystoma mexicanum induced by sediment elutriates from the Lake Xochimilco","volume":"46","author":"E Ortiz-Ordo\u00f1ez","year":"2016","journal-title":"J Environ Sci (China)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"112409","DOI":"10.1016\/j.biopha.2021.112409","article-title":"Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF\/c-Met, Wnt\/\u03b2-catenin, and PI3K\/Akt\/mTOR signaling pathways","volume":"145","author":"N YS Yassin","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.33545\/26164485.2021.v5.i1d.316","article-title":"Effect of Carduus marrianus and Chelidonium majus in hepatic damage","volume":"5","author":"R Kandasamy","year":"2021","journal-title":"Int J Homoeopath"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/d41586-017-05921-w","article-title":"Biology's beloved amphibian - the axolotl - is racing towards 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