{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:39:28Z","timestamp":1788244768475,"version":"build-2803163510"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Background\u2003Extracellular vesicles (EVs), shed in response to cell activation, stress, or injury, are increased in the blood of patients with cardiovascular disease. EVs are characterized by expressing parental-cell antigens, allowing the determination of their cellular origin. Platelet-derived EVs (pEVs) are the most abundant in blood. Although not universally given, EVs generally express phosphatidylserine (PS) in their membrane.<\/jats:p><jats:p>Objectives\u2003To investigate pEVs in chronic and acute conditions, such as chronic heart failure (CHF) and first-onset acute coronary syndrome (ACS), in patients treated as per guidelines.<\/jats:p><jats:p>Methods\u2003EVs in CHF patients (n\u2009=\u2009119), ACS patients (n\u2009=\u200958), their respective controls (non-CHF [n\u2009=\u200921] and non-ACS [n\u2009=\u200924], respectively), and a reference control group (n\u2009=\u200931) were characterized and quantified by flow cytometry, using monoclonal antibodies against platelet antigens, and annexin V (AV) to determine PS exposure.<\/jats:p><jats:p>Results\u2003CHF patients had higher EVs-PS\u2212 numbers, while ACS had predominantly EVs-PS+. In contrast to ACS, CHF patients had significantly reduced numbers of pEVs carrying PECAM and \u03b1IIb-integrin epitopes (CD31+\/AV+, CD41a+\/AV+, and CD31+\/CD41a+\/AV+), while no differences were observed in P-selectin-rich pEVs (CD62P+\/AV+) compared with controls. Additionally, background etiology of CHF (ischemic vs. nonischemic) or ACS type (ST-elevation myocardial infarction [STEMI] vs. non-STEMI [NSTEMI]) did not affect pEV levels.<\/jats:p><jats:p>Conclusion\u2003PS exposure in EV and pEV-release differ between CHF and ACS patients, with tentatively different functional capacities beyond coagulation to inflammation and cross-talk with other cell types.<\/jats:p>","DOI":"10.1055\/s-0043-57017","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T22:54:19Z","timestamp":1681944859000},"page":"892-903","source":"Crossref","is-referenced-by-count":15,"title":["Platelet-Released Extracellular Vesicle Characteristics Differ in Chronic and in Acute Heart Disease"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6957-4043","authenticated-orcid":false,"given":"Alba","family":"Vilella-Figuerola","sequence":"additional","affiliation":[{"name":"Cardiovascular Program-ICCC, Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"},{"name":"Biochemistry and Molecular Biology Department, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-7109","authenticated-orcid":false,"given":"Alberto","family":"Cordero","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario de San Juan, Alicante, Spain"},{"name":"Unidad de Investigaci\u00f3n en Cardiolog\u00eda, Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana (FISABIO), Val\u00e8ncia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-2748","authenticated-orcid":false,"given":"S\u00f2nia","family":"Mirabet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Heart Failure Group, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-8982","authenticated-orcid":false,"given":"Nat\u00e0lia","family":"Mu\u00f1oz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiovascular Program-ICCC, Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, 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