{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T22:45:41Z","timestamp":1750113941202},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monatsbl Augenheilkd"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>In der multifaktoriellen Pathogenese der glaukomat\u00f6sen Optikusatrophie spielen endotheliale Dysfunktion und vaskul\u00e4re Dysregulation eine Rolle. Eine Hyperhomocystein\u00e4mie als Risikofaktor f\u00fcr die endotheliale Dysfunktion ist sowohl mit dem prim\u00e4ren Offenwinkelglaukom als auch mit dem sekund\u00e4ren Offenwinkelglaukom bei Pseudoexfoliationssyndrom assoziiert. In dieser \u00dcbersichtsarbeit wird die aktuelle Datenlage zur Assoziation zwischen Homocysteinmetabolismus und Glaukomerkrankung dargelegt sowie eine m\u00f6gliche Rolle der Hyperhomocystein\u00e4mie in der Pathogenese und Progression der Glaukomerkrankung erl\u00e4utert. Die Bedeutung von Homocystein f\u00fcr die Regulationsst\u00f6rung der extrazellul\u00e4ren Matrix, der Vasotoxizit\u00e4t, der Neurodegeneration sowie der Epigenetik wird dargelegt. Die Pr\u00e4vention und Therapie der Glaukomerkrankung durch Beeinflussung des Homocysteinspiegels wird diskutiert.<\/jats:p>","DOI":"10.1055\/s-0044-101621","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:36:55Z","timestamp":1518719815000},"page":"163-174","source":"Crossref","is-referenced-by-count":4,"title":["Stellenwert vom Homocystein beim Glaukom"],"prefix":"10.1055","volume":"235","author":[{"given":"Anselm","family":"J\u00fcnemann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsaugenklinik, Universit\u00e4tsmedizin Rostock, Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rejdak","sequence":"additional","affiliation":[{"name":"Tadeusz Krwawicz Chair of Ophthalmology, Medical University, Chmielna, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Hohberger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Augenklinik, Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,2,15]]},"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-101621.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:37:02Z","timestamp":1518719822000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-101621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2018,2,15]]},"published-print":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-101621","relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}