{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:20:40Z","timestamp":1772191240184,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction  Many antidepressants cause QT prolongation but the classification of cardiac risk of these drugs varies markedly in different published lists. This retrospective study analyzed the correlation of QTc time with amitriptyline and venlafaxine serum level in elderly psychiatric inpatients.<\/jats:p><jats:p>\nMethods  Elderly inpatients aged\u226565 years for whom venlafaxine or amitriptyline serum level had been measured were selected retrospectively from a therapeutic drug monitoring database and screened for an electrocardiogram measurement at the time of blood withdrawal. The correlation of amitriptyline or venlafaxine serum levels with QTc time was examined by using Pearson\u2019s correlation analysis.<\/jats:p><jats:p>\nResults  Amitriptyline serum levels (n=11) correlated significantly with QTc time (r=0.918, p&lt;0.001, CI 95%). Venlafaxine serum levels (n=27) also correlated significantly with QTc time (r=0.382, p&lt;0.05, CI 95%).<\/jats:p><jats:p>\nDiscussion  Amitriptyline and venlafaxine induce QT prolongation depending on drug concentrations in blood. Its extent, however, is very low when drug serum levels are within the therapeutic range. Future pharmacokinetic studies that correlate drug serum level and QT time should classify the cardiac risk of drugs based on the grade of the regression line in relation to the therapeutic range.<\/jats:p>","DOI":"10.1055\/s-0044-102009","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:02:40Z","timestamp":1519257760000},"page":"38-43","source":"Crossref","is-referenced-by-count":20,"title":["QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients"],"prefix":"10.1055","volume":"52","author":[{"given":"Gudrun","family":"Hefner","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital, Vitos Klinik Hochtaunus, Friedrichsdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Hahn","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital, Vitos Klinik Eichberg, Eltville, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hohner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybille","family":"Roll","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital, Vitos Klinik Eichberg, Eltville, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Klimke","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital, Vitos Klinik Hochtaunus, Friedrichsdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hiemke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,2,21]]},"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-102009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:45:23Z","timestamp":1547804723000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-102009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-102009","relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}