{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:45:10Z","timestamp":1740145510779,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Brachial Plex Peripher Nerve Inj"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brachial plexus birth injuries cause diminished motor function in the upper extremity. The most common sequel is internal rotation contracture. A number of these patients also suffer from cocontractions, preventing the use of an otherwise good passive range of motion in the shoulder. One theory behind the co-contracture problem is that injured nerve fibers grow into distal support tissue not corresponding to the proximal support tissue, resulting in reinnervation of the wrong muscle groups. To further elucidate this hypothesis, we used rat neonates to investigate a possible model for the study of cocontractions in brachial plexus birth injuries. Five-day-old rats were subjected to a crush injury to the C5\u2013C6 roots. After a healing period of 4 weeks, the infraspinatus muscle was injected with Fluoro-Gold. A week later, the animals were perfused and spinal cords harvested and sectioned. Differences in the uptake of Fluoro-Gold and NeuN positive cells of between sides of the spinal cord were recorded. We found a larger amount of Fluoro-Gold positive cells on the uninjured side, while the injured side had positive cells dispersed over a longer area in the craniocaudal direction. Our findings indicate that the method can be used to trace Fluoro-Gold from muscle through a neuroma. Our results also indicate that a neuroma in continuity somewhat prevents the correct connection from being established between the motor neuron pool in the spinal cord and target muscle and that some neurons succumb to a crushing injury. We also present future research ideas.<\/jats:p>","DOI":"10.1055\/s-0044-1778691","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T23:30:21Z","timestamp":1705966221000},"page":"e6-e12","source":"Crossref","is-referenced-by-count":0,"title":["Nerve Tracing in Juvenile Rats: A Feasible Model for the Study of Brachial Plexus Birth Palsy and Cocontractions?"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-4572","authenticated-orcid":false,"given":"Krister","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Department of Handsurgery S\u00f6dersjukhuset, Karolinska Institutet Department of Clinical Science and Education, S\u00f6dersjukhuset, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Hultgren","sequence":"additional","affiliation":[{"name":"Department of Handsurgery S\u00f6dersjukhuset, Karolinska Institutet Department of Clinical Science and Education, S\u00f6dersjukhuset, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5rten","family":"Risling","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet, Experimental Traumatology Unit, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-0691","authenticated-orcid":false,"given":"Mattias K.","family":"Sk\u00f6ld","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet, Experimental Traumatology Unit, Sweden"},{"name":"Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1469-8749.2009.03479.x","article-title":"Obstetric brachial plexus palsy: a prospective, population-based study of incidence, recovery, and residual impairment at 18 months of age","volume":"52","author":"A L Lagerkvist","year":"2010","journal-title":"Dev Med Child Neurol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s12178-016-9374-3","article-title":"The natural history and management of brachial plexus birth palsy","volume":"9","author":"K L Buterbaugh","year":"2016","journal-title":"Curr Rev Musculoskelet Med"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1302\/0301-620X.95B10.32049","article-title":"Surgical correction of a rotational deformity of the shoulder in patients with obstetric brachial plexus palsy: short-term results in 270 patients","volume":"95-B","author":"T Hultgren","year":"2013","journal-title":"Bone Joint J"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1302\/0301-620X.96B10.33813","article-title":"Surgical correction of shoulder rotation deformity in brachial plexus birth palsy: long-term results in 118 patients","volume":"96-B","author":"T Hultgren","year":"2014","journal-title":"Bone Joint J"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.jse.2019.02.025","article-title":"Development of the glenohumeral joint after subscapular release and open relocation in children with brachial plexus birth palsy: long-term results in 61 patients","volume":"28","author":"K J\u00f6nsson","year":"2019","journal-title":"J Shoulder Elbow Surg"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00000658-190507000-00008","article-title":"VIII. 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