{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:05:59Z","timestamp":1784736359138,"version":"3.55.0"},"reference-count":66,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Plast Surg"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limb amputations can be devastating and significantly affect an individual's independence, leading to functional and psychosocial challenges in nearly 2 million people in the United States alone. Over the past decade, robotic devices driven by neural signals such as neuroprostheses have shown great potential to restore the lost function of limbs, allowing amputees to regain movement and sensation. However, current neuroprosthetic interfaces have challenges in both signal quality and long-term stability. To overcome these limitations and work toward creating bionic limbs, the Neuromuscular Laboratory at University of Michigan Plastic Surgery has developed the Regenerative Peripheral Nerve Interface (RPNI). This surgical construct embeds a transected peripheral nerve into a free muscle graft, effectively amplifying small peripheral nerve signals to provide enhanced control signals for a neuroprosthetic limb. Furthermore, the RPNI has the potential to provide sensory feedback to the user and facilitate neuroprosthesis embodiment. This review focuses on the animal studies and clinical trials of the RPNI to recapitulate the promising trajectory toward neurobionics where the boundary between an artificial device and the human body becomes indistinct. This paper also sheds light on the prospects of the improvement and dissemination of the RPNI technology.<\/jats:p>","DOI":"10.1055\/s-0044-1779028","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:01:21Z","timestamp":1707264081000},"page":"010-018","source":"Crossref","is-referenced-by-count":8,"title":["Merging Humans and Neuroprosthetics through Regenerative Peripheral Nerve Interfaces"],"prefix":"10.1055","volume":"38","author":[{"given":"Yucheng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex K.","family":"Vaskov","sequence":"additional","affiliation":[{"name":"Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Widya","family":"Adidharma","sequence":"additional","affiliation":[{"name":"Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Cederna","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan"},{"name":"Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.P.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan"},{"name":"Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, 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reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study","volume":"369","author":"T A Kuiken","year":"2007","journal-title":"Lancet"},{"issue":"222","key":"ref8","doi-asserted-by":"crossref","first-page":"222ra19","DOI":"10.1126\/scitranslmed.3006820","article-title":"Restoring natural sensory feedback in real-time bidirectional hand prostheses","volume":"6","author":"S Raspopovic","year":"2014","journal-title":"Sci Transl Med"},{"issue":"18","key":"ref9","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1056\/NEJMoa1917537","article-title":"Self-contained neuromusculoskeletal arm prostheses","volume":"382","author":"M Ortiz-Catalan","year":"2020","journal-title":"N Engl J Med"},{"issue":"83","key":"ref10","doi-asserted-by":"crossref","first-page":"eadf7360","DOI":"10.1126\/scirobotics.adf7360","article-title":"A highly integrated bionic hand with neural control and feedback for use in daily life","volume":"8","author":"M Ortiz-Catalan","year":"2023","journal-title":"Sci Robot"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"026017","DOI":"10.1088\/1741-2560\/13\/2\/026017","article-title":"Individual finger control of a modular prosthetic limb using high-density electrocorticography in a human subject","volume":"13","author":"G Hotson","year":"2016","journal-title":"J Neural Eng"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.pbr.2016.04.016","article-title":"Multisession, noninvasive closed-loop neuroprosthetic control of grasping by upper limb amputees","volume":"228","author":"H A Agashe","year":"2016","journal-title":"Prog Brain Res"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/s18103342","article-title":"EEG-based control for upper and lower limb exoskeletons and prostheses: a systematic review","volume":"18","author":"M S Al-Quraishi","year":"2018","journal-title":"Sensors (Basel)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fnins.2017.00379","article-title":"Self-recalibrating surface EMG pattern recognition for neuroprosthesis control based on Convolutional Neural Network","volume":"11","author":"X Zhai","year":"2017","journal-title":"Front Neurosci"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41551-021-00732-x","article-title":"Toward higher-performance bionic limbs for wider clinical use","volume":"7","author":"D Farina","year":"2023","journal-title":"Nat Biomed Eng"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"066013","DOI":"10.1088\/1741-2560\/11\/6\/066013","article-title":"Real-time simultaneous and proportional myoelectric control using intramuscular EMG","volume":"11","author":"L H Smith","year":"2014","journal-title":"J Neural 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Ghafoor","year":"2017","journal-title":"Front Neurorobot"},{"key":"ref36","first-page":"5726730","article-title":"Development of a regenerative peripheral nerve interface for control of a neuroprosthetic limb","author":"M G Urbanchek","year":"2016","journal-title":"BioMed Res Int"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42234-021-00062-y","article-title":"Cut wires: the electrophysiology of regenerated tissue","volume":"7","author":"A L Lowe","year":"2021","journal-title":"Bioelectron Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.prs.0000421762.53265.54","article-title":"Quantification of regenerative peripheral nerve interface signal transmission","volume":"130","author":"S L Woo","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/mus.26860","article-title":"The future of upper extremity 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amputees","volume":"12","author":"P P Vu","year":"2020","journal-title":"Sci Transl Med"},{"issue":"06","key":"ref43","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/PRS.0000000000000168","article-title":"Regenerative peripheral nerve interface viability and signal transduction with an implanted electrode","volume":"133","author":"T A Kung","year":"2014","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12984-017-0243-0","article-title":"Adjacent regenerative peripheral nerve interfaces produce phase-antagonist signals during voluntary walking in rats","volume":"14","author":"D Ursu","year":"2017","journal-title":"J Neuroeng Rehabil"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"046007","DOI":"10.1088\/1741-2560\/13\/4\/046007","article-title":"Chronic recording of hand prosthesis control signals via a regenerative peripheral nerve interface in a rhesus macaque","volume":"13","author":"Z T Irwin","year":"2016","journal-title":"J Neural Eng"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1109\/TNSRE.2017.2772961","article-title":"Closed-loop continuous hand control via chronic recording of regenerative peripheral nerve interfaces","volume":"26","author":"P P Vu","year":"2018","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"issue":"02","key":"ref47","doi-asserted-by":"crossref","first-page":"026039","DOI":"10.1088\/1741-2552\/accb0c","article-title":"Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes","volume":"20","author":"P P Vu","year":"2023","journal-title":"J Neural Eng"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0749-0712(02)00130-0","article-title":"Biomechanics and hand trauma: what you need","volume":"19","author":"S L Moran","year":"2003","journal-title":"Hand Clin"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1109\/TRO.2022.3170720","article-title":"Surgically implanted electrodes enable real-time finger and grasp pattern recognition for prosthetic hands","volume":"38","author":"A K Vaskov","year":"2022","journal-title":"IEEE Trans Robot"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"13840","DOI":"10.1038\/s41598-017-14386-w","article-title":"Myoelectric pattern recognition outperforms direct control for transhumeral amputees with targeted muscle reinnervation: a randomized clinical trial","volume":"7","author":"L J Hargrove","year":"2017","journal-title":"Sci Rep"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2012.6346539","article-title":"Reduction of the effect of arm position variation on real-time performance of Motion Classification","author":"Y Geng","year":"2012","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"11","key":"ref52","doi-asserted-by":"crossref","first-page":"e0186318","DOI":"10.1371\/journal.pone.0186318","article-title":"Real-time robustness evaluation of regression based myoelectric control against arm position change and donning\/doffing","volume":"12","author":"H-J Hwang","year":"2017","journal-title":"PLoS ONE"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12984-018-0361-3","article-title":"Evaluation of EMG pattern recognition for upper limb prosthesis control: a case study in comparison with direct myoelectric control","volume":"15","author":"L Resnik","year":"2018","journal-title":"J Neuroeng Rehabil"},{"issue":"06","key":"ref54","doi-asserted-by":"crossref","first-page":"066010","DOI":"10.1088\/1741-2552\/ac9e1c","article-title":"Use of regenerative peripheral nerve interfaces and intramuscular electrodes to improve prosthetic grasp selection: a case study","volume":"19","author":"C Lee","year":"2022","journal-title":"J Neural Eng"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1109\/JPROC.2016.2607520","article-title":"Stable detection of movement intent from peripheral nerves: chronic study in dogs","volume":"105","author":"Y M Dweiri","year":"2017","journal-title":"Proc IEEE"},{"issue":"06","key":"ref56","doi-asserted-by":"crossref","first-page":"1149e","DOI":"10.1097\/PRS.0000000000009153","article-title":"Restoration of proprioceptive and cutaneous sensation using regenerative peripheral nerve interfaces in humans with upper limb amputations","volume":"149","author":"P P Vu","year":"2022","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2018.08.033","article-title":"Biomimetic intraneural sensory feedback enhances sensation naturalness, tactile sensitivity, and manual dexterity in a bidirectional 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