{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:48:05Z","timestamp":1790700485615,"version":"4.1.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003We aimed to determine whether exposure to severe maternal preeclampsia (PE) in very low birth weight (VLBW) infants is associated with hypertrophic cardiac changes and altered hemodynamics.<\/jats:p><jats:p>\n            Study Design\u2003Case\u2013control study of VLBW infants born at Los Angeles General Medical Center from May 2015 to August 2023, who had an echocardiogram within the first 7 days of life. Cases were infants exposed to maternal PE and controls were infants not exposed to maternal PE matched by birth weight (BW) 1:1. Laboratory, placental pathology results, hemodynamic data and clinical outcomes were collected and compared between cases and control infants.<\/jats:p><jats:p>\n            Results\u2003A total of 43 cases matched by BW with control infants were studied. There were no significant anatomical cardiac changes by echocardiography between cases and control infants. Cases had significantly higher blood pressure within the first 72\u2009hours of life and lower ejection fraction (EF), fractional shortening, and peak systolic flow velocity through their patent ductus arteriosus (PDA) within the first week of life. Cases were more likely to be smaller despite being born at a later gestational age (GA), as well as small for GA with placental weight less than 10th percentile compared to control infants.<\/jats:p><jats:p>\n            Conclusion\u2003Our findings indicate that infants born to mothers with PE have higher systemic vascular resistance as evidenced by elevated blood pressure, and lower EF and shortening fraction and higher pulmonary vascular resistance as evidenced by lower peak flow velocity through the PDA. We did not observe hypertrophic cardiac changes in exposed infants. These findings should be considered in clinical decision-making during management of these infants.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0044-1779254","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:08:52Z","timestamp":1706141332000},"page":"e3413-e3419","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Effect of Maternal Preeclampsia on Cardiac Structure and Function in Very Low Birth Weight Infants"],"prefix":"10.1055","volume":"41","author":[{"given":"GoleNaz A.","family":"Kohbodi","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena G.","family":"Cayabyab","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutuja N.","family":"Kibe","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorayne","family":"Barton","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merujan Y.","family":"Uzunyan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-601X","authenticated-orcid":false,"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Los Angeles General Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222","volume":"135","author":"Gestational Hypertension and Preeclampsia","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"e003906","DOI":"10.1161\/JAHA.116.003906","article-title":"Hypertensive disorders of pregnancy and offspring cardiac structure and function in adolescence","volume":"5","author":"S Timpka","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.earlhumdev.2016.09.007","article-title":"Preeclampsia; short and long-term consequences for mother and neonate","volume":"102","author":"A Bokslag","year":"2016","journal-title":"Early Hum Dev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"214365","DOI":"10.1155\/2011\/214365","article-title":"Maternal preeclampsia and neonatal outcomes","volume":"2011","author":"C H Backes","year":"2011","journal-title":"J Pregnancy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.preghy.2020.03.006","article-title":"Adverse maternal and neonatal outcomes among women with preeclampsia with severe features <34 weeks gestation with versus without comorbidity","volume":"20","author":"K K Venkatesh","year":"2020","journal-title":"Pregnancy Hypertens"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1542\/neo.12-4-e198","article-title":"Preeclampsia: effect on the fetus and newborn","volume":"12","author":"L MS de Souza Rugolo","year":"2011","journal-title":"Neoreviews"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/10641955.2020.1866008","article-title":"Pathological investigation of placentas in preeclampsia (the PEARL study)","volume":"40","author":"A Fillion","year":"2021","journal-title":"Hypertens Pregnancy"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"S E Maynard","year":"2011","journal-title":"Semin Nephrol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/tropej\/fmp025","article-title":"Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother","volume":"55","author":"M Z Howlader","year":"2009","journal-title":"J Trop Pediatr"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"79.e1","DOI":"10.1016\/j.ajog.2019.07.025","article-title":"Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction","volume":"222","author":"L Youssef","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"07","key":"ref11","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s00246-013-0702-8","article-title":"Assessment of fetal cardiac function in mild preeclampsia","volume":"34","author":"S Balli","year":"2013","journal-title":"Pediatr Cardiol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000014089","article-title":"Diagnostic value of troponin T in neonates of mild pre-eclamptic mothers","volume":"75","author":"N Narin","year":"1999","journal-title":"Biol Neonate"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/01443615.2017.1322564","article-title":"Echocardiographic evaluation of cardiac functions in newborns of mildly preeclamptic pregnant women within postnatal 24-48\u2009hours","volume":"38","author":"K Mutlu","year":"2018","journal-title":"J Obstet Gynaecol"},{"issue":"22","key":"ref14","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1161\/CIRCULATIONAHA.110.937995","article-title":"Fetal growth restriction results in remodeled and less efficient hearts in children","volume":"121","author":"F Crispi","year":"2010","journal-title":"Circulation"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"L A Papile","year":"1978","journal-title":"J Pediatr"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2214\/ajr.143.5.1041","article-title":"Natural history of neonatal periventricular\/intraventricular hemorrhage and its complications: sonographic observations","volume":"143","author":"R A Bowerman","year":"1984","journal-title":"AJR Am J Roentgenol"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0031-3955(05)70413-2","article-title":"Necrotizing enterocolitis: the search for a unifying pathogenic theory leading to prevention","volume":"43","author":"J Neu","year":"1996","journal-title":"Pediatr Clin North Am"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archopht.123.7.991","article-title":"The International Classification of Retinopathy of Prematurity revisited","volume":"123","author":"International Committee for the Classification of Retinopathy of Prematurity","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","article-title":"Bronchopulmonary dysplasia: executive summary of a workshop","volume":"197","author":"R D Higgins","year":"2018","journal-title":"J Pediatr"},{"key":"ref20","volume-title":"Practical Neonatal Echocardiography","author":"B Siassi","year":"2019"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/15513819609168713","article-title":"Reference values for singleton and twin placental weights","volume":"16","author":"H Pinar","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/apm.12858","article-title":"Re-view and view on maturation disorders in the placenta","volume":"126","author":"G Turowski","year":"2018","journal-title":"APMIS"},{"issue":"07","key":"ref23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group Consensus Statement","volume":"140","author":"T Y Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1538-7836.2008.03259.x","article-title":"Vascular biology of preeclampsia","volume":"7","author":"L Myatt","year":"2009","journal-title":"J Thromb Haemost"},{"key":"ref25","volume-title":"Pediatric Critical Care","author":"J Zimmerman","year":"2011"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"530.e1","DOI":"10.1016\/j.ajog.2008.12.031","article-title":"Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood","volume":"200","author":"M Boutet","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preghy.2012.01.001","article-title":"The placenta in preeclampsia","volume":"2","author":"J M Roberts","year":"2012","journal-title":"Pregnancy Hypertens"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.placenta.2007.04.009","article-title":"Reference weights for placentas delivered before the 28th week of gestation","volume":"28","author":"J L Hecht","year":"2007","journal-title":"Placenta"},{"issue":"06","key":"ref29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/00016340802056178","article-title":"Placenta weight in pre-eclampsia","volume":"87","author":"B Dahlstr\u00f8m","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"579293","DOI":"10.3389\/fped.2020.579293","article-title":"Neonatal outcome after preeclampsia and HELLP Syndrome: a population-based cohort study in Germany","volume":"8","author":"V Bossung","year":"2020","journal-title":"Front Pediatr"},{"issue":"03","key":"ref31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0022-3476(05)83294-9","article-title":"Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia","volume":"125","author":"M W Doron","year":"1994","journal-title":"J Pediatr"},{"issue":"08","key":"ref32","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.placenta.2014.05.003","article-title":"Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension","volume":"35","author":"K K Mestan","year":"2014","journal-title":"Placenta"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1385\/ENDO:19:1:103","article-title":"Role of placenta in preeclampsia","volume":"19","author":"L Myatt","year":"2002","journal-title":"Endocrine"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpeds.2010.08.051","article-title":"Maternal preeclampsia protects preterm infants against severe retinopathy of prematurity","volume":"158","author":"J B Fortes Filho","year":"2011","journal-title":"J Pediatr"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1542\/peds.2011-3881","article-title":"Preeclampsia and retinopathy of prematurity in preterm births","volume":"130","author":"X D Yu","year":"2012","journal-title":"Pediatrics"},{"issue":"09","key":"ref36","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jamaophthalmol.2017.2697","article-title":"Association of maternal preeclampsia with infant risk of premature birth and retinopathy of prematurity","volume":"135","author":"J P Shulman","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preghy.2019.09.015","article-title":"Association of serum angiogenic factors with bronchopulmonary dysplasia. The ANGIODYS cohort study","volume":"18","author":"H Torchin","year":"2019","journal-title":"Pregnancy Hypertens"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1779254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:50:29Z","timestamp":1730814629000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1779254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":37,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1779254","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}