{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:13:27Z","timestamp":1773263607921,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Rapid spread of the SARS-CoV-2 pandemic in 2020 led to an indirect effect on non-COVID patients. Since neuro-oncology cases are unique and brain tumors need a specific therapeutic protocol at proper doses and at the right times, the effects of the pandemic on health care services for patients with glioblastomas (GBs) and their impact on overall survival (OS) and quality of life are not yet known.<\/jats:p><jats:p>\n          Methods\u2003We conducted a retrospective study of 142 GB patients who underwent surgery, radiation, and chemotherapy before and after the lockdown period, aiming to determine the differences in access to care, treatment modality, and adjuvant therapies, and how the lockdown changed the prognosis.<\/jats:p><jats:p>\n          Results\u2003The number of procedures performed for GB during the pandemic was comparable to that of the prepandemic period, and patients received standard care. There was a significant difference in the volume of lesions measured at diagnosis with a decreased number of \u201caccidental\u201d diagnoses and expression of a reduced use by the patient for a checkup or follow-up examinations. Patients expressed a significantly lower performance index in the lockdown period with longer progression-free survival (PFS) in the face of a comparable mean time to OS.<\/jats:p><jats:p>\n          Conclusion\u2003Patients treated surgically for GB during the pandemic period had a more pronounced and earlier reduction in performance status than patients treated during the same period the year before. This appears to be primarily due to lower levels of care in the rehabilitation centers and more frequent discontinuation of adjuvant care.<\/jats:p>","DOI":"10.1055\/s-0044-1779262","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T23:00:43Z","timestamp":1720047643000},"page":"120-127","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of the COVID-19 Pandemic and Lockdown on the Outcome of Glioblastoma"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-5534","authenticated-orcid":false,"given":"Daniele","family":"Armocida","sequence":"additional","affiliation":[{"name":"Neurosurgery Division, Human Neurosciences Department, \u201cSapienza\u201d University, Rome, Italy"},{"name":"IRCCS \u201cNeuromed\u201d Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Neurosurgery Division, Human Neurosciences Department, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella De","family":"Pietro","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Policlinico Umberto I \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Chiarello","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Policlinico Umberto I \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Neurosurgery Division, Human Neurosciences Department, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, AOU Citt\u00e0 della Salute e della Scienza, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Garbossa","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, AOU Citt\u00e0 della Salute e della Scienza, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Frati","sequence":"additional","affiliation":[{"name":"IRCCS \u201cNeuromed\u201d Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marampon","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Policlinico Umberto I \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Santoro","sequence":"additional","affiliation":[{"name":"Neurosurgery Division, Human Neurosciences Department, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s11845-020-02429-7","article-title":"The provision of neuro-oncology and glioma neurosurgery during the SARS-CoV-2 pandemic: a single national tertiary centre experience","volume":"190","author":"M Amoo","year":"2021","journal-title":"Ir J Med Sci"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/neuonc\/noaa113","article-title":"Neuro-oncology management during the COVID-19 pandemic with a focus on WHO grades III and IV gliomas","volume":"22","author":"D Bernhardt","year":"2020","journal-title":"Neuro-oncol"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1473-3099(20)30243-7","article-title":"Estimates of the severity of coronavirus disease 2019: a model-based analysis","volume":"20","author":"R Verity","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.1093\/neuros\/nyaa115","article-title":"Letter: neurosurgery and coronavirus (COVID-19) epidemic: doing our part","volume":"87","author":"A Pesce","year":"2020","journal-title":"Neurosurgery"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"106126","DOI":"10.1016\/j.clineuro.2020.106126","article-title":"Is Ki-67 index overexpression in IDH wild type glioblastoma a predictor of shorter progression free survival? 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