{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:41Z","timestamp":1740142421581,"version":"3.37.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background There is very few data regarding homocysteine's influence on the formation and rupture of intracranial aneurysms.<\/jats:p><jats:p>\n          Objective To compare homocysteine levels between patients with ruptured and unruptured intracranial aneurysms, and to evaluate possible influences of this molecule on vasospasm and functional outcomes.<\/jats:p><jats:p>\n          Methods This is a retrospective, case-control study. We evaluated homocysteinemia differences between patients with ruptured and unruptured aneurysms; and the association of homocysteine levels with vasospasm and functional outcomes. Logistic regressions were performed.<\/jats:p><jats:p>\n          Results A total of 348 participants were included: 114 (32.8%) with previous aneurysm rupture and 234 (67.2%) with unruptured aneurysms. Median homocysteine was 10.75\u00b5mol\/L (IQR\u2009=\u20094.59) in patients with ruptured aneurysms and 11.5\u00b5mol\/L (IQR\u2009=\u20095.84) in patients with unruptured aneurysms. No significant association was detected between homocysteine levels and rupture status (OR\u2009=\u20090.99, 95% CI\u2009=\u20090.96-1.04). Neither mild (&gt;15\u00b5mol\/L; OR\u2009=\u20091.25, 95% CI 0.32-4.12) nor moderate (&gt;30\u00b5mol\/L; OR\u2009=\u20091.0, 95% CI\u2009=\u20090.54-1.81) hyperhomocysteinemia demonstrated significant correlations with ruptured aneurysms. Neither univariate (OR\u2009=\u20090.86; 95% CI 0.71-1.0) nor multivariable age-adjusted (OR\u2009=\u20090.91; 95% CI\u2009=\u20090.75-1.05) models evidenced an association between homocysteine levels and vasospasm. Homocysteinemia did not influence excellent functional outcomes at 6 months (mRS\u22641) (OR\u2009=\u20091.04; 95% CI\u2009=\u20090.94-1.16).<\/jats:p><jats:p>\n          Conclusion There were no differences regarding homocysteinemia between patients with ruptured and unruptured intracranial aneurysms. In patients with ruptured aneurysms, homocysteinemia was not associated with vasospasm or functional outcomes.<\/jats:p>","DOI":"10.1055\/s-0044-1779270","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T23:36:55Z","timestamp":1707349015000},"page":"001-006","source":"Crossref","is-referenced-by-count":1,"title":["Homocysteine serum levels in patients with ruptured and unruptured intracranial aneurysms: a case-control study"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-0405","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Mota Telles","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-6644","authenticated-orcid":false,"given":"Jefferson","family":"Rosi Junior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Divis\u00e3o de Neurocirurgia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-1731","authenticated-orcid":false,"given":"Vitor Nagai","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Divis\u00e3o de Neurocirurgia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-8658","authenticated-orcid":false,"given":"Nicollas Nunes","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Divis\u00e3o de Neurocirurgia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-6045","authenticated-orcid":false,"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Divis\u00e3o de Neurocirurgia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-4178","authenticated-orcid":false,"given":"Eberval Gadelha","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Divis\u00e3o de Neurocirurgia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1055\/s-2005-872394","article-title":"Homocysteine: overview of biochemistry, molecular biology, and role in disease processes","volume":"5","author":"B Fowler","year":"2005","journal-title":"Semin Vasc 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