{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:01Z","timestamp":1790009581409,"version":"4.0.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"DOI":"10.13039\/100020218","name":"Chiesi USA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020218","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n            Objective\u2003Administering surfactant timely and appropriately is important to minimize lung injury but remains challenging in preterm neonates with respiratory distress syndrome. The published literature supports that lung ultrasound (LUS) score can predict surfactant need. Neonatal LUS scanning specification and parameter setting guidelines have been recently published for standardization. However, variations in scanning protocols and machine settings hinder its clinical implementation widely. This observational study aims to internally validate the suggested LUS protocol in a neonatal intensive care unit to establish a correlation between LUS scores and surfactant need as the first step of integrating LUS in the clinical practice.<\/jats:p><jats:p>\n            Study Design\u2003LUS was performed on 40 eligible preterm neonates within 3\u2009hours after birth or before surfactant administration between May 2020 and March 2021. The neonates were between 27 and 32 weeks' gestational age, and all had respiratory distress. Neonates with known congenital anomalies were excluded. A high-frequency linear probe was used to obtain LUS images from six lung zones which were scored using a 0 to 3 system, yielding a maximum of 18 points. Treating physicians were blinded to the LUS score. Receiver operating characteristic analysis determined the optimal LUS score cut-off for predicting surfactant need.<\/jats:p><jats:p>\n            Results\u2003Fifteen of the 40 neonates (38%) required higher oxygen fraction and received surfactant. In our cohort, an LUS score \u226510 was identified as the optimal cut-off for predicting surfactant need, with a sensitivity of 80% and specificity of 84%. The area under the curve was 0.8 (p\u2009=\u20090.0003). LUS predicted surfactant need at a median of 3.5\u2009hours earlier than traditional clinical decision (p\u2009&lt;\u20090.0037).<\/jats:p><jats:p>\n            Conclusion\u2003LUS is a helpful adjunct for predicting surfactant need in preterm neonates. This study describes an approach to implement the LUS protocol and score for clinical decision-making in the clinical practice.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0044-1779500","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:33:53Z","timestamp":1707784433000},"page":"1652-1659","source":"Crossref","is-referenced-by-count":8,"title":["Substantiating and Adopting Lung Ultrasound Scores to Predict Surfactant Need in Preterm Neonates with Respiratory Distress Syndrome within an Institution"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-2572","authenticated-orcid":false,"given":"Belinda","family":"Chan","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, University of Utah, Salt Lake City, Utah"},{"name":"Department of Radiology and Imaging Science, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Torsitano","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, University of Utah, Salt Lake City, Utah"},{"name":"Department of Radiology and Imaging Science, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-8298","authenticated-orcid":false,"given":"Sasha","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olive","family":"Konana","sequence":"additional","affiliation":[{"name":"Neonatology Division, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-9019","authenticated-orcid":false,"given":"Yogen","family":"Singh","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"11","key":"ref1","first-page":"CD001456","article-title":"Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome","volume":"11","author":"F L Bahadue","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"21","key":"ref2","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1056\/NEJMoa0911783","article-title":"Early CPAP versus surfactant in extremely preterm infants","volume":"362","author":"N N Finer","year":"2010","journal-title":"N Engl J Med"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000528914","article-title":"European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update","volume":"120","author":"D G Sweet","year":"2023","journal-title":"Neonatology"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/archdischild-2022-324530","article-title":"Can we balance early exogenous surfactant therapy and non-invasive respiratory support to optimise outcomes in extremely preterm infants? 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