{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:17Z","timestamp":1787004917752,"version":"build-2736575974"},"reference-count":174,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Drug-induced liver injury (DILI) is an adverse reaction to medications and other xenobiotics that leads to liver dysfunction. Based on differential clinical patterns of injury, DILI is classified into hepatocellular, cholestatic, and mixed types; although hepatocellular DILI is associated with inflammation, necrosis, and apoptosis, cholestatic DILI is associated with bile plugs and bile duct paucity. Ursodeoxycholic acid (UDCA) has been empirically used as a supportive drug mainly in cholestatic DILI, but both curative and prophylactic beneficial effects have been observed for hepatocellular DILI as well, according to preliminary clinical studies. This could reflect the fact that UDCA has a plethora of beneficial effects potentially useful to treat the wide range of injuries with different etiologies and pathomechanisms occurring in both types of DILI, including anticholestatic, antioxidant, anti-inflammatory, antiapoptotic, antinecrotic, mitoprotective, endoplasmic reticulum stress alleviating, and immunomodulatory properties. In this review, a revision of the literature has been performed to evaluate the efficacy of UDCA across the whole DILI spectrum, and these findings were associated with the multiple mechanisms of UDCA hepatoprotection. This should help better rationalize and systematize the use of this versatile and safe hepatoprotector in each type of DILI scenarios.<\/jats:p>","DOI":"10.1055\/s-0044-1779520","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T18:48:21Z","timestamp":1708454901000},"page":"001-022","source":"Crossref","is-referenced-by-count":24,"title":["UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis"],"prefix":"10.1055","volume":"44","author":[{"given":"Fernando","family":"Bessone","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario, Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine L.","family":"Hillotte","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda Experimental (IFISE-CONICET), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ahumada","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario, Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Jaureguizahar","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario, Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabela C.","family":"Medeot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo G.","family":"Roma","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda Experimental (IFISE-CONICET), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1572-0241.2006.01019.x","article-title":"Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States?","volume":"102","author":"R Vuppalanchi","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2796.1992.tb00562.x","article-title":"Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987","volume":"232","author":"H Friis","year":"1992","journal-title":"J Intern Med"},{"issue":"04","key":"ref3","first-page":"43","article-title":"The epidemiology of acute liver failure","volume":"117","author":"N Weiler","year":"2020","journal-title":"Dtsch Arztebl Int"},{"issue":"20","key":"ref4","doi-asserted-by":"crossref","first-page":"11397","DOI":"10.1021\/acs.jmedchem.0c00524","article-title":"Drug induced liver injury (DILI). 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