{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:47:22Z","timestamp":1792532842063,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Global Medical Genetics"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1055\/s-0044-1779668","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T19:52:32Z","timestamp":1707767552000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Cytogenetics Aberrations and IGHV Mutations with Outcome in Chronic Lymphocytic Leukemia Patients in a Real-World Clinical Setting"],"prefix":"10.1016","volume":"11","author":[{"given":"Carolina","family":"Mu\u00f1oz-Novas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gonz\u00e1lez-Gasc\u00f3n-y-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"P\u00e9rez-Carretero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Quijada-\u00c1lamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Eugenia","family":"Rodr\u00edguez-Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Stefania","family":"Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-\u00c1ngeles","family":"Foncillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Landete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Churruca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro S\u00e1nchez","family":"Salto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-\u00c1ngel","family":"Hern\u00e1ndez-Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"01","key":"10.1055\/s-0044-1779668_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.canlet.2013.07.013","article-title":"Personalized medicine in CLL: current status and future perspectives","volume":"352","author":"Rozovski","year":"2014","journal-title":"Cancer Lett"},{"issue":"10","key":"10.1055\/s-0044-1779668_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41408-018-0131-2","article-title":"Chronic lymphocytic leukemia treatment algorithm 2018","volume":"8","author":"Parikh","year":"2018","journal-title":"Blood Cancer J"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphocytic leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"issue":"01","key":"10.1055\/s-0044-1779668_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","article-title":"A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis","volume":"48","author":"Binet","year":"1981","journal-title":"Cancer"},{"issue":"03","key":"10.1055\/s-0044-1779668_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ajh.23618","article-title":"Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data","volume":"89","author":"Baliakas","year":"2014","journal-title":"Am J Hematol"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41416-019-0502-x","article-title":"The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia","volume":"121","author":"Visentin","year":"2019","journal-title":"Br J Cancer"},{"issue":"06","key":"10.1055\/s-0044-1779668_bib7","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"issue":"06","key":"10.1055\/s-0044-1779668_bib8","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig Vgene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"issue":"13","key":"10.1055\/s-0044-1779668_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14133045","article-title":"Immunoglobulin gene sequence as an inherited and acquired risk factor for chronic lymphocytic leukemia","volume":"14","author":"Datta","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1182\/blood-2015-06-651125","article-title":"Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial","volume":"127","author":"Fischer","year":"2016","journal-title":"Blood"},{"issue":"06","key":"10.1055\/s-0044-1779668_bib11","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3324\/haematol.2019.220194","article-title":"IGHV mutational status and outcome for patients with chronic lymphocytic leukemia upon treatment: a Danish nationwide population-based study","volume":"105","author":"Rotbain","year":"2020","journal-title":"Haematologica"},{"issue":"06","key":"10.1055\/s-0044-1779668_bib12","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1470-2045(16)30029-8","article-title":"An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data","volume":"17","author":"International CLL-IPI working group","year":"2016","journal-title":"Lancet Oncol"},{"issue":"01","key":"10.1055\/s-0044-1779668_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.annonc.2020.09.019","article-title":"Electronic address: clinicalguidelines@esmo.org. Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Eichhorst","year":"2021","journal-title":"Ann Oncol"},{"issue":"17","key":"10.1055\/s-0044-1779668_bib15","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1182\/bloodadvances.2022008033","article-title":"Flow cytometry as a fast, cost-effective tool to assess IGHV mutational status in CLL","volume":"7","author":"Couillez","year":"2023","journal-title":"Blood Adv"},{"key":"10.1055\/s-0044-1779668_bib16","article-title":"Mutation status and immunoglobulin gene rearrangements in patients from northwest and central region of Spain with chronic lymphocytic leukemia","volume":"2014","author":"Gonz\u00e1lez-Gasc\u00f3n","year":"2014","journal-title":"BioMed Res Int"},{"issue":"15","key":"10.1055\/s-0044-1779668_bib17","doi-asserted-by":"crossref","first-page":"20520","DOI":"10.18632\/oncotarget.7819","article-title":"Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia","volume":"7","author":"Marinelli","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1055\/s-0044-1779668_bib18","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.leukres.2008.02.005","article-title":"Distinctive IgVH gene segments usage and mutation status in Chinese patients with chronic lymphocytic leukemia","volume":"32","author":"Chen","year":"2008","journal-title":"Leuk Res"},{"issue":"04","key":"10.1055\/s-0044-1779668_bib19","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1182\/blood-2004-07-2606","article-title":"Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3\u201321 gene","volume":"105","author":"Ghia","year":"2005","journal-title":"Blood"},{"issue":"07","key":"10.1055\/s-0044-1779668_bib20","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1182\/blood-2006-10-051110","article-title":"Comprehensive characterization of IGHV3\u201321-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study","volume":"109","author":"Bomben","year":"2007","journal-title":"Blood"},{"issue":"05","key":"10.1055\/s-0044-1779668_bib21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/bjh.16434","article-title":"Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations","volume":"189","author":"Raponi","year":"2020","journal-title":"Br J Haematol"},{"issue":"12","key":"10.1055\/s-0044-1779668_bib22","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997","volume":"17","author":"Harris","year":"1999","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1055\/s-0044-1779668_bib23","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"issue":"01","key":"10.1055\/s-0044-1779668_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.leu.2404457","article-title":"ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia","volume":"21","author":"Ghia","year":"2007","journal-title":"Leukemia"},{"issue":"03","key":"10.1055\/s-0044-1779668_bib25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/10428194.2017.1376748","article-title":"Chronic lymphocytic leukemia is becoming more complex: how to define complex karyotype?","volume":"59","author":"Kreinitz","year":"2018","journal-title":"Leuk Lymphoma"},{"issue":"11","key":"10.1055\/s-0044-1779668_bib26","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1182\/blood-2018-09-873083","article-title":"Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact","volume":"133","author":"Baliakas","year":"2019","journal-title":"Blood"},{"issue":"04","key":"10.1055\/s-0044-1779668_bib27","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.18632\/oncotarget.6727","article-title":"Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib","volume":"7","author":"Guo","year":"2016","journal-title":"Oncotarget"},{"issue":"20","key":"10.1055\/s-0044-1779668_bib28","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/1078-0432.CCR-18-0133","article-title":"The light chain IgLV3\u201321 defines a new poor prognostic subgroup in chronic lymphocytic leukemia: results of a multicenter study","volume":"24","author":"Stamatopoulos","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"04","key":"10.1055\/s-0044-1779668_bib29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4149\/neo_2015_074","article-title":"Biological and clinical characteristics of patients with chronic lymphocytic leukemia with the IGHV3\u201321 and IGHV1-69; analysis of data from a single center","volume":"62","author":"Urbanova","year":"2015","journal-title":"Neoplasma"},{"issue":"03","key":"10.1055\/s-0044-1779668_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.clml.2012.01.009","article-title":"IGHV3\u201321 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia","volume":"12","author":"Cahill","year":"2012","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"05","key":"10.1055\/s-0044-1779668_bib31","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1182\/blood-2014-09-600874","article-title":"Not all IGHV3\u201321 chronic lymphocytic leukemias are equal: prognostic considerations","volume":"125","author":"Baliakas","year":"2015","journal-title":"Blood"},{"issue":"07","key":"10.1055\/s-0044-1779668_bib32","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1182\/blood-2005-06-2227","article-title":"Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3\u201321-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status","volume":"107","author":"Thors\u00e9lius","year":"2006","journal-title":"Blood"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib33","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s12032-011-9872-5","article-title":"IGHV gene rearrangements as outcome predictors for CLL patients: experience of Ukrainian group","volume":"29","author":"Kryachok","year":"2012","journal-title":"Med Oncol"},{"issue":"08","key":"10.1055\/s-0044-1779668_bib34","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1182\/blood-2002-08-2432","article-title":"Features of the overexpressed V1\u201369 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire","volume":"101","author":"Potter","year":"2003","journal-title":"Blood"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.leukres.2006.05.008","article-title":"Chronic lymphocytic leukemia patients with a V1\u201369 gene rearrangement do not have inferior survival with respect to patients that express other unmutated V(H) genes","volume":"31","author":"Panovska-Stavridis","year":"2007","journal-title":"Leuk Res"},{"issue":"20","key":"10.1055\/s-0044-1779668_bib36","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1182\/blood-2009-05-221309","article-title":"Extensive intra-clonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4\u201334 receptors: implications for ongoing interactions with antigen","volume":"114","author":"Sutton","year":"2009","journal-title":"Blood"},{"issue":"02","key":"10.1055\/s-0044-1779668_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00277-021-04703-9","article-title":"Somatic hypermutation profiles in stereotyped IGHV4\u201334 receptors from South American chronic lymphocytic leukemia patients","volume":"101","author":"Stanganelli","year":"2022","journal-title":"Ann Hematol"},{"issue":"04","key":"10.1055\/s-0044-1779668_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clml.2012.03.005","article-title":"Mutational status and gene repertoire of IGHV-IGHD-IGHJ rearrangements in Serbian patients with chronic lymphocytic leukemia","volume":"12","author":"Karan-Djurasevic","year":"2012","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"01","key":"10.1055\/s-0044-1779668_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/10428194.2017.1323271","article-title":"Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia","volume":"59","author":"Sandoval-Sus","year":"2018","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"10.1055\/s-0044-1779668_bib40","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3109\/10428194.2011.585529","article-title":"Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia","volume":"52","author":"Gladstone","year":"2011","journal-title":"Leuk Lymphoma"},{"issue":"05","key":"10.1055\/s-0044-1779668_bib41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/cncr.23671","article-title":"Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia","volume":"113","author":"Kharfan-Dabaja","year":"2008","journal-title":"Cancer"},{"issue":"01","key":"10.1055\/s-0044-1779668_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/bjh.13933","article-title":"The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): the CLL Research Consortium experience","volume":"173","author":"Van Dyke","year":"2016","journal-title":"Br J Haematol"},{"issue":"26","key":"10.1055\/s-0044-1779668_bib43","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1182\/blood-2017-03-772285","article-title":"In CLL, comorbidities and the complex karyotype are associated with an inferior outcome independently of CLL-IPI","volume":"129","author":"Rigolin","year":"2017","journal-title":"Blood"},{"issue":"12","key":"10.1055\/s-0044-1779668_bib44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/gcc.22293","article-title":"Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: clinical and biologic correlations","volume":"54","author":"Rigolin","year":"2015","journal-title":"Genes Chromosomes Cancer"},{"issue":"06","key":"10.1055\/s-0044-1779668_bib45","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.3324\/haematol.2018.212571","article-title":"Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia","volume":"106","author":"Heerema","year":"2021","journal-title":"Haematologica"},{"issue":"25","key":"10.1055\/s-0044-1779668_bib46","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2017-09-806398","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","journal-title":"Blood"},{"issue":"14","key":"10.1055\/s-0044-1779668_bib47","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1182\/blood-2015-10-620864","article-title":"Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis","volume":"127","author":"Parikh","year":"2016","journal-title":"Blood"},{"issue":"07","key":"10.1055\/s-0044-1779668_bib48","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1001\/jamaoncol.2015.0779","article-title":"Predicting prognosis in chronic lymphocytic leukemia in the contemporary era","volume":"1","author":"Nabhan","year":"2015","journal-title":"JAMA Oncol"}],"container-title":["Global Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2699940425000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2699940425000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1779668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:36:39Z","timestamp":1761204999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2699940425000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2699940425000037"],"URL":"https:\/\/doi.org\/10.1055\/s-0044-1779668","relation":{},"ISSN":["2699-9404"],"issn-type":[{"value":"2699-9404","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Cytogenetics Aberrations and IGHV Mutations with Outcome in Chronic Lymphocytic Leukemia Patients in a Real-World Clinical Setting","name":"articletitle","label":"Article Title"},{"value":"Global Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1055\/s-0044-1779668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2024 International Knowledge Direct Medical Associations. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}