{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:32Z","timestamp":1787068052820,"version":"build-2736575974"},"reference-count":95,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date.<\/jats:p>\n                  <jats:p>Methods\u2003An electronic search of the published literature was performed without publication year limitation in PubMed\/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (\u201cBreast cancer\u201d, OR \u201cBreast carcinoma\u201d) AND (\u201cMetastasis\u201d OR \u201cMetastases\u201d), And (\u201cOral soft tissues\u201d OR \u201cTongue\u201d OR \u201cPalate\u201d OR \u201cTonsil\u201d OR \u201cBuccal mucosa\u201d OR \u201cFloor of mouth\u201d OR \u201cVestibule\u201d OR \u201cSalivary glands\u201d). We also searched all related journals manually. The reference list of all articles was also checked.<\/jats:p>\n                  <jats:p>Results\u2003Our research revealed 88 relevant papers (September 1967\u2013September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months.<\/jats:p>\n                  <jats:p>Conclusions\u2003Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.<\/jats:p>","DOI":"10.1055\/s-0044-1779674","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T19:53:36Z","timestamp":1709063616000},"page":"022-038","source":"Crossref","is-referenced-by-count":3,"title":["Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review"],"prefix":"10.1055","volume":"14","author":[{"given":"Nausheen","family":"Aga","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Dundee, Dundee, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchira","family":"Shreevats","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Primadent Dental Centre, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-5762","authenticated-orcid":false,"given":"Sonia","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology and Forensic Odontology, Yamuna Institute of Dental Sciences & Research, Gadholi, Yamunanagar, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harman","family":"Sandhu","sequence":"additional","affiliation":[{"name":"General Dentistry, Building Smiles Dental Clinic, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna E.M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry, University of Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harnisha V.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"General Dentistry, Bhavya Dental Clinic and Implant Centre, Palanpur, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"R L Siegel","year":"2022","journal-title":"CA Cancer J clin"},{"issue":"S 05","key":"ref2","doi-asserted-by":"crossref","first-page":"S518","DOI":"10.21037\/tcr.2019.07.24","article-title":"Rare sites of breast cancer metastasis: a review","volume":"8","author":"R Di Micco","year":"2019","journal-title":"Transl Cancer Res"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/2231-0762.192935","article-title":"Metastasis to the oral soft tissues: a review of 412 cases","volume":"6","author":"S Irani","year":"2016","journal-title":"J Int Soc Prev Community Dent"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/odi.13611","article-title":"Metastasis to the oral and maxillofacial region: a systematic review","volume":"28","author":"L B Kirschnick","year":"2022","journal-title":"Oral Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"D S Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"E von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"03","key":"ref7","first-page":"340","article-title":"Carcinoma of the breast metastatic to the anterior part of the tongue","volume":"4","author":"D R Meher-Homji","year":"1967","journal-title":"Indian J Cancer"},{"issue":"05","key":"ref8","first-page":"749","article-title":"Metastasis to the gingiva. 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