{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:58:49Z","timestamp":1778633929613,"version":"3.51.4"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Infective endocarditis (IE) remains a challenging disease associated with high mortality. Several scores have been suggested to assess surgical risk. None was sufficiently adequate. We therefore analyzed risk factors for 30-day mortality.<\/jats:p><jats:p>\n          Methods\u2003A total of 438 consecutive patients had surgery for IE in our department between 2002 and 2020. Patients were divided into two groups, one consisting of 30-day survivors (362 patients; 82.6%) and one of nonsurvivors (76 patients; 17.4%). Logistic regression analysis on pre- and intraoperative risk factors was performed and the groups were compared by univariable analyses.<\/jats:p><jats:p>\n          Results\u2003Patients in mortality group were older (69 [58, 77] vs. 63 [50, 72] years; p\u2009&lt;\u20090.001), EuroSCORE II was higher (24.5 [12.1, 49.0] vs. 8.95 [3.7, 21.2]; p\u2009&lt;\u20090.001) and there were more females. More frequently left ventricular function (below 30%), preoperative acute renal insufficiency, chronic dialysis, insulin-dependent diabetes mellitus, NYHA-class IV (New York Heart Association heart failure class IV), and cardiogenic shock occurred. Patients in the mortality group were often intensive care unit patients (40.8 vs. 22.4%; p\u2009&lt;\u20090.001) or had a preoperative stroke (26.3 vs. 16.0%; p\u2009=\u20090.033). In the nonsurvivor group Staphylococcus aureus was prevalent. Streptococcus viridans was common in the survivor group as was isolated aortic valve endocarditis (32.9 vs. 17.1%; p\u2009=\u20090.006). Prosthetic valve endocarditis (PVE) and abscesses occurred more often in nonsurvivors. In the logistic regression analysis, female gender, chronic dialysis, cardiogenic shock, and NYHA IV and from intraoperative variables PVE, cardiopulmonary bypass time, and mitral valve surgery were the strongest predictors for 30-day mortality.<\/jats:p><jats:p>\n          Conclusion\u2003This study indeed clearly indicates that significant risk factors for 30-day mortality cannot be changed. Nevertheless, they should be taken into account for preoperative counselling, and they will alert the surgical team for an even more careful management.<\/jats:p>","DOI":"10.1055\/s-0044-1779709","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:42:15Z","timestamp":1708389735000},"page":"595-606","source":"Crossref","is-referenced-by-count":11,"title":["Risk Factor Analysis for 30-day Mortality After Surgery for Infective Endocarditis"],"prefix":"10.1055","volume":"72","author":[{"given":"Jill","family":"Jussli-Melchers","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kira","family":"Mandler","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Hosam","family":"Alosh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ahmed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department for Cardiac Surgery, Justus Liebig Universitat Giessen Fachbereich Medizin, Gie\u00dfen, Hessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Schoettler","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universitatsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assad","family":"Haneya","sequence":"additional","affiliation":[{"name":"Department for Cardiac Surgery, Krankenhaus der Barmherzigen Br\u00fcder, Heart Center Trier, Trier, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1093\/jac\/dkad155","article-title":"Differential response to antibiotic therapy in staphylococcal infective endocarditis: contribution of an ex vivo model","volume":"78","author":"S Lalanne","year":"2023","journal-title":"J Antimicrob 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are we running into trouble?","volume":"56","author":"J M Albes","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3390\/jcm11071875","article-title":"Sex-specific risk factors for short- and long-term outcomes after surgery in patients with infective endocarditis","volume":"11","author":"C Friedrich","year":"2022","journal-title":"J Clin Med"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.CIR.91.3.677","article-title":"Multicenter validation of a risk index for mortality, intensive care unit stay, and overall hospital length of stay after cardiac surgery","volume":"91","author":"J V Tu","year":"1995","journal-title":"Circulation"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/ejcts\/ezv223","article-title":"EuroSCORE II underestimates mortality after cardiac surgery for infective 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and endocarditis","volume":"130","author":"V G Fowler Jr","year":"2020","journal-title":"J Clin Invest"},{"issue":"01","key":"ref19","first-page":"153","article-title":"Perioperative red blood cell transfusion is associated with adverse cardiovascular outcomes in heart valve surgery","volume":"137","author":"H J Kim","year":"2023","journal-title":"Anesth Analg"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3349\/ymj.2022.0324","article-title":"Identification of biomarkers for the diagnosis of sepsis-associated acute kidney injury and prediction of renal recovery in the intensive care unit","volume":"64","author":"S H Kwak","year":"2023","journal-title":"Yonsei Med J"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-0042-1748950","article-title":"Endocarditis: who is particularly at risk and why? Ten years analysis of risk factors for in-hospital mortality in infective endocarditis","volume":"71","author":"R Ostovar","year":"2023","journal-title":"Thorac Cardiovasc Surg"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1779709.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T23:42:51Z","timestamp":1732664571000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1779709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":21,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,11,26]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1779709","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]}}}