{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:55:38Z","timestamp":1782366938847,"version":"3.54.5"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Multiparametric magnetic resonance imaging (mpMRI) is widely used for the evaluation of prostate cancer and is known to have better accuracy. Gallium-68 prostate-specific membrane antigen (Ga-68 PSMA) is a radiotracer that shows high localization in prostate cancer cells.<\/jats:p><jats:p>\n          Purpose\u2003The purpose of this study was to assess the sensitivity and utility of Ga-68 PSMA positron emission tomography\/computed tomography (PET\/CT) in comparison with mpMRI as a noninvasive imaging technique for the initial diagnosis and locoregional staging of prostate cancer using transrectal ultrasound (TRUS)-guided biopsy as gold standard.<\/jats:p><jats:p>\n          Materials and Methods\u2003This prospective observational study conducted from August 2017 to April 2020 evaluated 60 men (n\u2009=\u200960) with biopsy-proven prostate carcinoma. They underwent mpMRI and Ga-68 PSMA PET\/CT scans within 14 days with TRUS biopsy being gold standard. T staging of disease, N staging of lymph nodes within the pelvis, and M staging of lesions in pelvic bones (within the imaging field of mpMRI) were compared using PSPP version 1.0.1 statistical software.<\/jats:p><jats:p>\n          Results\u2003All 60 men with a mean age of 69.9\u2009\u00b1\u20099.35 years showed Ga-68 PSMA avid disease, whereas 55 were detected by mpMRI. The sensitivity in detection of prostate lesions (with 95% confidence interval) was 99.08% for Ga-68 PSMA PET\/CT and 84.40% for mpMRI. Ga-68 PSMA PET\/CT detected greater number of patients with regional lymph nodal involvement (19\/60) as compared with mpMRI (12\/60). Ga-68 PSMA PET\/CT showed PSMA avid pelvic skeletal lesions in nine patients, whereas mpMRI detected pelvic lesions in six patients. In addition, four other patients showed extrapelvic skeletal lesions on Ga-68 PSMA PET\/CT.<\/jats:p><jats:p>\n          Conclusion\u2003Ga-68 PSMA PET\/CT has superior sensitivity in detection of primary prostate tumor, as compared with mpMRI. Both modalities correlate well in detection of seminal vesicle involvement. Ga-68 PSMA PET\/CT outperformed mpMRI in detection of lymph nodal and skeletal metastases. Hence, Ga-68 PSMA PET\/CT should be considered as first-line diagnostic modality for carcinoma prostate.<\/jats:p><jats:p>\n          Summary Statement:\u2003Ga-68 PSMA PET\/CT shows superior diagnostic performance than mpMRI in the evaluation of prostate cancer.<\/jats:p>","DOI":"10.1055\/s-0044-1779749","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T22:44:42Z","timestamp":1712011482000},"page":"079-087","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Ga-68 PSMA PET\/CT and Multiparametric MRI for Initial Detection and Staging of Prostate Cancer"],"prefix":"10.1055","volume":"23","author":[{"given":"Dinesh Kumar","family":"Gauthaman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT, Jaslok Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Luthra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT, Jaslok Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Lele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT, Jaslok Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"J Ferlay","year":"2015","journal-title":"Int J Cancer"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"J 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