{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:36:37Z","timestamp":1747748197126,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Objective\u2003Ocular hemorrhages (OHs) may cause visual disturbances and incidence vary from 18 to 39% in newborns. Precipitated\/instrumental delivery and perinatal asphyxia were predefined risk factors. Acidosis can interfere with coagulation and disrupt the pressure of ocular capillaries and put infants with moderate acidosis with or without hypoxic\u2013ischemic encephalopathy at risk for OH. We aimed to evaluate the OH in neonates with fetal acidosis.<\/jats:p><jats:p>Study Design Neonates &gt;34 weeks are included if pH\u2009&lt;\u20097.10 and BE\u2009&lt;\u2009 \u221212\u2009mmol\/L within the first hour. Ophthalmologic examinations for retinal (RH), vitreous, and anterior chamber (hyphema) hemorrhage were done within the third day. RH was staged according to Egge's classification. Follow-up of the patients was continued until the age of 2. Clinical characteristics of newborns were analyzed.<\/jats:p><jats:p>Results\u2003Sixty-two neonates (38\u2009\u00b1\u20092.3 weeks, 2,971\u2009\u00b1\u2009612\u2009g) were included. pH\u2009=\u20096.91\u2009\u00b1\u20090.16, BE\u2009=\u2009\u2212\u200917.2\u2009\u00b1\u20095.3\u2009mmol\/L. OH was found in 22 (36.7%) neonates (hyphema n\u2009=\u20092, vitreous n\u2009=\u20092, RH n\u2009=\u200921). Thirty-eight eyes with RH were staged (Stage 3: n\u2009=\u200915 [39.5%]; Stage 2: n =11 [28.9%]; Stage 1: n\u2009=\u200912 [31.6%]). Vaginal delivery (OR: 4.9, 95% CI [1.4\u201317.8]) and advanced resuscitation at the delivery room (OR: 8.8; 95% CI [1.9\u201341.7]) were found to increase the risk of RH.<\/jats:p><jats:p>Conclusion\u2003Approximately one-third of neonates with moderate to severe acidosis exhibited RH when examined on the third day. Contrary to previous studies that reported mild RH in otherwise healthy neonates, our findings revealed that neonates with moderate to severe acidosis predominantly presented with Stage 3 RH. While the higher incidence of RH in vaginally delivered infants is consistent with previous studies, the identification of advanced resuscitation as a risk factor is a new addition to the literature. The findings in our study highlight the importance of retinal examination in neonates with acidosis in the presence of intubation during resuscitation.<\/jats:p><jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0044-1780512","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:26:12Z","timestamp":1708129572000},"page":"1755-1760","source":"Crossref","is-referenced-by-count":2,"title":["Should Ocular Hemorrhage Screening Be Conducted in Newborns with Acidosis?"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-4422","authenticated-orcid":false,"given":"Sezin","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Neonatology\/Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Demirel","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seza","family":"Petri\u00e7li","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumru","family":"Kavurt","sequence":"additional","affiliation":[{"name":"Department of Neonatology\/Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Uzlu","sequence":"additional","affiliation":[{"name":"Department of Neonatology\/Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehtap","family":"Durukan","sequence":"additional","affiliation":[{"name":"Department of Neonatology\/Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Maternity Teaching and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Yagmur","family":"Bas","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaapos.2012.07.012","article-title":"Newborn retinal hemorrhages: a systematic review [published correction appears in J AAPOS. 17(2013) 70\u201378","volume":"17","author":"P Watts","year":"2013","journal-title":"J AAPOS"},{"issue":"06","key":"ref2","first-page":"e8400","article-title":"uncommon presentations of multiple myeloma","volume":"12","author":"P Tathineni","year":"2020","journal-title":"Cureus"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/ijo.IJO_928_22","article-title":"Vitreous hemorrhage - 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