{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:20:32Z","timestamp":1793740832193,"version":"4.6.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to describe target oxygen saturation (SpO2) ranges used for premature infants in United States' neonatal intensive care units (NICUs) and to describe if these target SpO2 ranges have changed in recent years.<\/jats:p><jats:p>\n            Study Design\u2003A 29-question survey focused on target SpO2 practices and policies was distributed via the NICU medical directors listservs for the American Academy of Pediatrics Section of Neonatal-Perinatal Medicine and Pediatrix Medical Group between August and October of 2021. Results were collected via Research Electronic Data Capture (REDCap).<\/jats:p><jats:p>\n            Results\u2003We received responses representing 170 unique, levels 2, 3, and 4 NICUs from 36 states. Most NICUs (130, 78%) have recently changed their SpO2 targets in response to target SpO2 clinical trials. Over time, the most commonly reported target SpO2 range has shifted from 88\u201392% to 90\u201395. Of NICUs that changed limits, the most common lower SpO2 limits increased from 88 to 90% and the upper SpO2 limits changed from 92 to 95%. The interquartile range for lower SpO2 limit shifted from 85\u201388% to 88\u201390% and the IQR for upper SpO2 limit decreased from 92\u201395 to 94\u201395%. Most NICUs had designated conditions that would allow for deviations from standard target SpO2 ranges. These most commonly include pulmonary hypertension (152, 95%), severe bronchopulmonary dysplasia (81, 51%), and retinopathy of prematurity (51, 32%).<\/jats:p><jats:p>\n            Conclusion\u2003Oxygen saturation limits have changed over time with an overall increase in targeted SpO2. However, there remains considerable interunit variation in SpO2 policies. There is a need to achieve consensus to optimize clinical outcomes.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0044-1780523","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:37:55Z","timestamp":1708389475000},"page":"1728-1735","source":"Crossref","is-referenced-by-count":4,"title":["Variability in Practice and Implementation of Oxygen Target Saturation Policies in United States' Neonatal Intensive Care Units"],"prefix":"10.1055","volume":"41","author":[{"given":"Pratik","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Christus Children Hospital, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"White","sequence":"additional","affiliation":[{"name":"Regional Newborn Program, Beacon Children's Hospital, South Bend, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeral N.","family":"Tolia","sequence":"additional","affiliation":[{"name":"Pediatrix Center for Research, Education, Quality and Safety, Sunrise, Florida"},{"name":"Department of Pediatrics, Baylor University Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Reyburn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baptist Children\u2019s Hospital at North Central, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charleta","family":"Guillory","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Neonatal-Perinatal Public Health Program, Texas Children's Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaashif A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Pediatrix Center for Research, Education, Quality and Safety, Sunrise, Florida"},{"name":"Department of Neonatology, The Woman's Hospital of Texas, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1542\/peds.113.2.394","article-title":"A cautionary tale about supplemental oxygen: the albatross of neonatal medicine","volume":"113","author":"W A Silverman","year":"2004","journal-title":"Pediatrics"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.clp.2019.05.008","article-title":"Oxygen saturation and retinopathy of prematurity","volume":"46","author":"R D Higgins","year":"2019","journal-title":"Clin Perinatol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1056\/NEJMoa1514212","article-title":"Outcomes of two trials of oxygen-saturation targets in preterm infants","volume":"374","author":"W Tarnow-Mordi","year":"2016","journal-title":"N Engl J Med"},{"issue":"22","key":"ref4","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1056\/NEJMoa1302298","article-title":"Oxygen saturation and outcomes in preterm infants","volume":"368","author":"B J Stenson","year":"2013","journal-title":"N Engl J Med"},{"issue":"21","key":"ref5","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa0911781","article-title":"Target ranges of oxygen saturation in extremely preterm infants","volume":"362","author":"W A Carlo","year":"2010","journal-title":"N Engl J Med"},{"issue":"26","key":"ref6","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1056\/NEJMoa1208506","article-title":"Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial","volume":"367","author":"Y E Vaucher","year":"2012","journal-title":"N Engl J Med"},{"issue":"21","key":"ref7","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1001\/jama.2018.5725","article-title":"Association between oxygen saturation targeting and death or disability in extremely preterm infants in the Neonatal Oxygenation Prospective Meta-analysis collaboration","volume":"319","author":"L M Askie","year":"2018","journal-title":"JAMA"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"e20161576","DOI":"10.1542\/peds.2016-1576","article-title":"Oxygen targeting in extremely low birth weight infants","volume":"138","author":"J J Cummings","year":"2016","journal-title":"Pediatrics"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000448985","article-title":"European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update","volume":"111","author":"D G Sweet","year":"2017","journal-title":"Neonatology"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00431-016-2804-9","article-title":"Pulse oximeter saturation target limits for preterm infants: a survey among European neonatal intensive care units","volume":"176","author":"M J Huizing","year":"2017","journal-title":"Eur J Pediatr"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000490372","article-title":"Variations in Oxygen Saturation Targeting, and Retinopathy of Prematurity Screening and Treatment Criteria in Neonatal Intensive Care Units: An International Survey","volume":"114","author":"B A Darlow","year":"2018","journal-title":"Neonatology"},{"issue":"S 01","key":"ref12","doi-asserted-by":"crossref","first-page":"A53","DOI":"10.1136\/archdischild-2014-306237.125","article-title":"G125(P) Oxygen saturation target monitoring in preterm babies: a survey of level 3 units in United Kingdom","volume":"99","author":"R Sutton","year":"2014","journal-title":"Arch Dis Child"},{"issue":"22","key":"ref13","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1056\/NEJMe1305534","article-title":"Oxygen-saturation targets in preterm infants","volume":"368","author":"R A Polin","year":"2013","journal-title":"N Engl J Med"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000499361","article-title":"European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update","volume":"115","author":"D G Sweet","year":"2019","journal-title":"Neonatology"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/apa.12692","article-title":"Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?","volume":"103","author":"A Sola","year":"2014","journal-title":"Acta Paediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpeds.2015.10.005","article-title":"Higher rates of retinopathy of prematurity after increasing oxygen saturation targets for very preterm infants: experience in a single center","volume":"168","author":"B J Manley","year":"2016","journal-title":"J Pediatr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/pm-21-77","article-title":"Safe and sound oxygen therapy for extremely preterm infants: a literature review","volume":"5","author":"B Schmidt","year":"2022","journal-title":"Pediatr Med"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1001\/jamapediatrics.2014.3307","article-title":"Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis","volume":"169","author":"V Manja","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1542\/peds.2005-0413","article-title":"Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study","volume":"118","author":"J I Hagadorn","year":"2006","journal-title":"Pediatrics"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1542\/peds.105.2.295","article-title":"Supplemental Therapeutic Oxygen for Prethreshold Retinopathy Of Prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes","volume":"105","author":"The STOP-ROP Multicenter Study Group","year":"2000","journal-title":"Pediatrics"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1167\/iovs.16-20822","article-title":"Use of a supplemental oxygen protocol to suppress progression of retinopathy of prematurity","volume":"58","author":"T T Colaizy","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1780523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:10:47Z","timestamp":1730805047000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1780523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,8,16]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1780523","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]}}}