{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:20:57Z","timestamp":1776309657638,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012521","name":"Universitas Gadjah Mada","doi-asserted-by":"crossref","award":["5075\/UN1.P.II\/Dit-Lit\/PT.01.01\/2023"],"award-info":[{"award-number":["5075\/UN1.P.II\/Dit-Lit\/PT.01.01\/2023"]}],"id":[{"id":"10.13039\/501100012521","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003The development of remineralization biomimetics using organic peptide molecules is expected to resemble the hydroxyapatite (HA) mineralization process in tooth enamel. The development of an amelogenin derivative peptide combined with antimicrobial peptide was designed, resulting in QP3VH. This combination then was mixed with chitosan as a carrier. This study aimed to evaluate the biomimetic efficacy of QP3VH as a remineralizing agent combined with chitosan.<\/jats:p><jats:p>\n          Materials and Methods\u2003Fifty deciduous mandibular incisor enamel samples were used in this study. The artificial enamel lesions were created on a buccal surface and were randomly assigned to five groups of 10 each according to the remineralizing agent used: QP3VH, NaF, QP3VH\u2009+\u2009NaF, QP3VH\u2009+\u2009CS (QP3VH\u2009+\u2009chitosan), and saline distilled water (SDW). Each group was performed pH cycling for seven days. Enamel surface morphology and evaluation of mineral content Ca\/P (calcium and phosphate) using scanning electron microscopy and energy dispersive X-ray analysis. The assessment was carried out, after demineralization, and after application with remineralization agents.<\/jats:p><jats:p>\n          Statistical Analysis\u2003Data were analyzed using a one-way analysis of variance followed by least significance difference post-hoc test. The paired t-test was utilized to compare the demineralization and remineralization results. The significance level used was 95%.<\/jats:p><jats:p>\n          Results\u2003The remineralized group exhibited a significant increase in calcium and phosphate content on the enamel surface (p &lt;0.05), and QP3VH\u2009+\u2009CS produced the maximum Ca\/P mass percent after remineralization.<\/jats:p><jats:p>\n          Conclusion\u2003Combining QP3VH with chitosan produces greatest remineralization than QP3VH, QP3VH\u2009+\u2009NaF, Naf, and SDW; therefore, QP3VH peptide has potential as a remineralizing agent, in the future<\/jats:p>","DOI":"10.1055\/s-0044-1782189","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T23:23:44Z","timestamp":1715988224000},"page":"1149-1156","source":"Crossref","is-referenced-by-count":3,"title":["The Potential of QP3VH-Chitosan Peptide as Biomimetic Remineralization in Early Dental Caries Treatment: An In Vitro Study"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-3778","authenticated-orcid":false,"given":"Prima","family":"Agusmawanti","sequence":"additional","affiliation":[{"name":"Doctoral Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia"},{"name":"Departement of Pediatric Dentistry, Faculty of Dentistry, Universitas Islam Sultan Agung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5584-1403","authenticated-orcid":false,"given":"Diatri Nari","family":"Ratih","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4360-6358","authenticated-orcid":false,"given":"Nunuk","family":"Purwanti","sequence":"additional","affiliation":[{"name":"Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-5241","authenticated-orcid":false,"given":"Tri Joko","family":"Raharjo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"issue":"09","key":"ref1","first-page":"661","article-title":"The global burden of oral diseases and risks to oral health","volume":"83","author":"P E Petersen","year":"2005","journal-title":"Bull World Health Organ"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.eclinm.2018.06.006","article-title":"Child dental caries - a global problem of inequality","volume":"1","author":"D J 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