{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:02:26Z","timestamp":1788465746871,"version":"build-2803163510"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Neutrophils own an arsenal of dischargeable chemicals that enable them to handle bacterial challenges, manipulating innate immune response and actual participation in acquired immunity. The reactive oxygen species (ROS) are one of the most important chemicals that neutrophils discharge to eradicate pathogens. Despite their beneficial role, the ROS were strongly correlated to periodontal tissue destruction. Lowdensity neutrophils (LDN) have been recognized for producing enhanced quantities of ROS. However, the potential role of ROS produced by LDN in periodontitis is unknown. The aim of the study was to investigate the impact of ROS produced by LDN in periodontal diseases.<\/jats:p><jats:p>\n          Materials and Methods\u2003Venous blood and periodontal parameters were obtained from 100 systemically healthy subjects divided into 40 participants with healthy periodontium in the control group and 60 with unstable periodontitis in the study group. Flow cytometry was used to measure the production of ROS by LDN in both groups.<\/jats:p><jats:p>\n          Statistical Analysis\u2003The data were analyzed for normal distribution using the Shapiro-Wilk test at p\u2009&lt;\u20090.05, Spearman's correlations, and Mann-Whitney U test. Statistical analysis was performed in SPSS v25.<\/jats:p><jats:p>\n          Results\u2003No difference between the groups had been obtained in ROS production by LDN. However, a significant positive correlation existed between ROS and clinical attachment loss in periodontitis.<\/jats:p><jats:p>\n          Conclusion\u2003LDN exhibits the same ROS generation capacity in the control and periodontitis groups.<\/jats:p>","DOI":"10.1055\/s-0044-1782211","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T23:11:01Z","timestamp":1715728261000},"page":"1142-1148","source":"Crossref","is-referenced-by-count":8,"title":["The Potential Role of Reactive Oxygen Species Produced by Low-Density Neutrophils in Periodontitis"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1325-1437","authenticated-orcid":false,"given":"Ali Omran","family":"Mousa","sequence":"additional","affiliation":[{"name":"Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-8834","authenticated-orcid":false,"given":"Ali Hussien Abass","family":"Al Hussaini","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-2768","authenticated-orcid":false,"given":"Hashim Mueen","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, College of Dentistry, Mustansiriyah University, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jdsr.2022.09.001","article-title":"Pathogenesis of periodontitis: a potential role for epithelial-mesenchymal 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