{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T14:54:01Z","timestamp":1745852041182,"version":"3.28.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Mechanical assist device indications have changed in recent years. Reduced incidence of complications, better survival, and the third generation of mechanical support devices contributed to this change. In this single-center study, we focused on two time periods that are characterized by the use of different types of mechanical support devices, different patient characteristics, and change in the indications.<\/jats:p><jats:p>\n          Methods\u2003The data were processed from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). We retrospectively defined two time intervals to reflect changes in ventricular assist device technology (period 1: 2007\u20132015; period 2: 2016\u201320222). A total of 181 patients underwent left ventricular assist device implantation. Device utilization was the following: HeartMate II\u2009=\u200952 (76.4%) and HeartWare\u2009=\u200916 (23.6%) in period 1 and HeartMate II\u2009=\u20092 (1.8%), HeartMate 3\u2009=\u200970 (61:9%), HeartWare\u2009=\u200929 (25.7%), SynCardia TAH\u2009=\u200910 (8.8%), and BerlinHeart EXCOR\u2009=\u20092 (1.8%) in period 2. The outcomes of the time intervals were analyzed and evaluated.<\/jats:p><jats:p>\n          Results\u2003Survival was significantly higher during the second time period. Multivariate analysis revealed that age and bypass pump time are independent predictors of mortality. Idiopathic cardiomyopathy, bypass time, and the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) score are independent predictors of adverse events. Furthermore, the first period was noted to be at an increased risk of the following adverse events: pump thrombosis, gastrointestinal bleeding, and bleeding events.<\/jats:p><jats:p>\n          Conclusion\u2003Despite the higher risk profile of the patients and persistent challenges, during the second period, there was a significant decrease in mortality and morbidity. The use of the HeartMate 3 device may have contributed to this result.<\/jats:p>","DOI":"10.1055\/s-0044-1782600","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T23:59:41Z","timestamp":1713571181000},"page":"521-529","source":"Crossref","is-referenced-by-count":2,"title":["Temporal Analysis in Outcomes of Long-Term Mechanical Circulatory Support: Retrospective Study"],"prefix":"10.1055","volume":"72","author":[{"given":"Matej","family":"Ondrusek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular diseases, Clinic of Cardiac Surgery, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Artemiou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular diseases, Clinic of Cardiac Surgery, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislav","family":"Bezak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular diseases, Clinic of Cardiac Surgery, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Gasparovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular diseases, Clinic of Cardiac Surgery, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo MMH de","family":"By","sequence":"additional","affiliation":[{"name":"EUROMACS, European Association for Cardio-Thoracic Surgery (EACTS), Windsor, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Durdik","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Comenius University, St. Elizabeth Oncology Institute, Clinic of Surgical Oncology, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lesny","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular Diseases, Clinic of Heart Failure, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Goncalvesova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular Diseases, Clinic of Heart Failure, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Hulman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the Comenius University, National Institute of Cardiovascular diseases, Clinic of Cardiac Surgery, Bratislava, 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