{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:45:13Z","timestamp":1790981113321,"version":"4.1.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Sinonasal inverted papilloma (SNIP) is a rare benign epithelial tumor of the nasal cavity and paranasal sinuses that accounts for 0.4% and 4.7% respectively, of all tumors of this anatomical region.<\/jats:p><jats:p>\n          Objective\u2003To analyze the outcomes after surgical resection of SNIP and identify the risk factors for recurrence in a Swiss tertiary center.<\/jats:p><jats:p>\n          Methods\u2003We conducted a retrospective review of all cases of SNIP treated at the Lausanne university hospital between 2005 and 2018. All data available on the patients and tumors were collected for analysis. We studied the recurrence rate and looked for risk factors.<\/jats:p><jats:p>\n          Results\u2003We included 57 patients with a mean age of 55.5 years. There were 46 primary cases (80.7%) and 11 recurrences (19.3%). Maxillary sinus was the most frequent location (33.3%). Approximately half of the patients (52.6%) presented with a T3 tumor according to the Krouse classification. The mean recurrence rate after surgery was of 17.5% and it was more frequent among the patients in the recurrence group (45.5%) than among the primary cases (10.9%), reaching statistical significance (odds ratio [OR]\u2009=\u20096.8; 95% confidence interval [95%CI]: 1.5\u201330.8; p\u2009=\u20090.0165). Most patients were treated endoscopically (94.7%). Frontal sinus location, higher Krouse stage, and combined approach seemed to increase the risk of recurrence, but without statistical significance.<\/jats:p><jats:p>\n          Conclusion\u2003Difficult surgical access, as in the case of tumors located in the frontal sinus, higher stage of the disease, and previously operated cases carry the higher risk of incomplete resection and recurrence.<\/jats:p>","DOI":"10.1055\/s-0044-1785206","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T22:30:20Z","timestamp":1716676220000},"page":"e568-e573","source":"Crossref","is-referenced-by-count":6,"title":["Risk Factors for Recurrence after Surgical Resection of Sinonasal Inverted Papilloma"],"prefix":"10.1055","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-4214","authenticated-orcid":false,"given":"Eug\u00e9nie","family":"Delaine","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose, and Throat, Hopital du Valais, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gorostidi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Guilcher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karma","family":"Lambercy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Litzistorf","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/014556130608500201","article-title":"World Health Organization classification of tumours: pathology and genetics of head 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Rhinol"},{"issue":"02","key":"ref8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12105-008-0048-3","article-title":"The role of the human papillomavirus in the pathogenesis of Schneiderian inverted papillomas: an analytic overview of the evidence","volume":"2","author":"W Lawson","year":"2008","journal-title":"Head Neck Pathol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/lary.5541040513","article-title":"The inverted Schneiderian papilloma: a 25-year study","volume":"104","author":"D P Vrabec","year":"1994","journal-title":"Laryngoscope"},{"issue":"06","key":"ref10","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1097\/00005537-200006000-00015","article-title":"Development of a staging system for inverted papilloma","volume":"110","author":"J H Krouse","year":"2000","journal-title":"Laryngoscope"},{"issue":"06","key":"ref11","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/alr.22305","article-title":"Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta-analysis","volume":"9","author":"R Peng","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"issue":"03","key":"ref12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/lary.22495","article-title":"Inverted papilloma of the nasal cavity and paranasal sinuses: a Korean multicenter study","volume":"122","author":"D Y Kim","year":"2012","journal-title":"Laryngoscope"},{"issue":"05","key":"ref13","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.anorl.2016.03.006","article-title":"Sinonasal inverted papilloma: From diagnosis to treatment","volume":"133","author":"Q Lisan","year":"2016","journal-title":"Eur Ann Otorhinolaryngol Head Neck 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Laryngol"},{"issue":"05","key":"ref20","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.anl.2019.02.007","article-title":"Attachment-oriented endoscopic surgical management for inverted papillomas in the nasal cavity and paranasal sinuses","volume":"46","author":"S Makihara","year":"2019","journal-title":"Auris Nasus Larynx"},{"issue":"07","key":"ref21","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00405-018-4995-3","article-title":"Optical coherence tomography and confocal laser scanning microscopy as non-invasive tools in the diagnosis of sinonasal inverted papilloma: a pilot study","volume":"275","author":"A \u00d3v\u00e1ri","year":"2018","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"04","key":"ref22","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.amjoto.2018.03.025","article-title":"Optical imaging with a high-resolution microendoscope to identify sinonasal pathology","volume":"39","author":"S M Kidwai","year":"2018","journal-title":"Am J Otolaryngol"},{"issue":"05","key":"ref23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/00016489.2021.1890819","article-title":"Storz Professional Image Enhancement System (SPIES) endoscopy in the detection of sinonasal inverted papilloma: a pilot study","volume":"141","author":"M Li","year":"2021","journal-title":"Acta Otolaryngol"},{"issue":"02","key":"ref24","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/00016480500312554","article-title":"Histopathological parameters of recurrence and malignant transformation in sinonasal inverted papilloma","volume":"126","author":"H Katori","year":"2006","journal-title":"Acta Otolaryngol"},{"issue":"06","key":"ref25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5604\/01.3001.0009.38","article-title":"Endoscopic surgical management of sinonasal inverted papilloma extending to frontal sinuses","volume":"70","author":"Y Takahashi","year":"2016","journal-title":"Otolaryngol Pol"}],"container-title":["International Archives of 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