{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:28:52Z","timestamp":1764588532325,"version":"3.28.0"},"reference-count":80,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Posttraumatic epilepsy (PTE) is a complication of traumatic brain injury that can increase morbidity, but predicting which patients may develop PTE remains a challenge. Much work has been done to identify a variety of risk factors and biomarkers, or a combination thereof, for patients at highest risk of PTE. However, several issues have hampered progress toward fully adapted PTE models. Such issues include the need for models that are well-validated, cost-effective, and account for competing outcomes like death. Additionally, while an accurate PTE prediction model can provide quantitative prognostic information, how such information is communicated to inform shared decision-making and treatment strategies requires consideration of an individual patient's clinical trajectory and unique values, especially given the current absence of direct anti-epileptogenic treatments. Future work exploring approaches integrating individualized communication of prediction model results are needed.<\/jats:p>","DOI":"10.1055\/s-0044-1785502","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:16:00Z","timestamp":1713226560000},"page":"333-341","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Implications of Early Prediction in Posttraumatic Epilepsy"],"prefix":"10.1055","volume":"44","author":[{"given":"Yilun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie P.","family":"Cappucci","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"S 02","key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1528-1167.2008.02006.x","article-title":"Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis","volume":"50","author":"R Diaz-Arrastia","year":"2009","journal-title":"Epilepsia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1528-1157.44.s10.4.x","article-title":"Epidemiology of posttraumatic epilepsy: a critical review","volume":"44","author":"L C Frey","year":"2003","journal-title":"Epilepsia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0140-6736(09)60214-2","article-title":"Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study","volume":"373","author":"J Christensen","year":"2009","journal-title":"Lancet"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM199801013380104","article-title":"A population-based study of seizures after traumatic brain injuries","volume":"338","author":"J F Annegers","year":"1998","journal-title":"N Engl J Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1111\/epi.13582","article-title":"Incidence and risk factors of posttraumatic seizures following traumatic brain injury: a Traumatic Brain Injury Model Systems Study","volume":"57","author":"A C Ritter","year":"2016","journal-title":"Epilepsia"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM199008233230801","article-title":"A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures","volume":"323","author":"N R Temkin","year":"1990","journal-title":"N Engl J Med"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1042-3680(18)30427-3","article-title":"Penetrating injuries in the Vietnam war. 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