{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:36:44Z","timestamp":1740148604827,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O tromboembolismo venoso (TEV) ainda \u00e9 um grande desafio ap\u00f3s grandes cirurgias ortop\u00e9dicas, incluindo a artroplastia total do joelho (ATJ). O objetivo deste estudo foi estimar o risco de TEV com profilaxia farmacol\u00f3gica apenas com \u00e1cido acetilsalic\u00edlico ou anticoagulante oral direto (AOD) ap\u00f3s a cirurgia prim\u00e1ria de ATJ.<\/jats:p><jats:p>\n          M\u00e9todos\u2003O estudo incluiu 476 pacientes submetidos a ATJ prim\u00e1ria de 2016 a 2020. Todos os pacientes receberam tromboprofilaxia com AOD (grupo AOD) (n\u2009=\u2009267) ou \u00e1cido acetilsalic\u00edlico (AAS) (grupo AAS) (n\u2009=\u2009209). Os desfechos cl\u00ednicos foram avaliados e comparados entre aqueles que receberam AOD e AAS. O desfecho prim\u00e1rio foi a incid\u00eancia de TEV. O desfecho secund\u00e1rio foi a ocorr\u00eancia de complica\u00e7\u00f5es da ferida.<\/jats:p><jats:p>\n          Resultado\u2003O AAS e o AOD foram compar\u00e1veis na preven\u00e7\u00e3o de TEV em pacientes submetidos a ATJ prim\u00e1ria. A incid\u00eancia de trombose venosa profunda foi semelhante nos grupos AAS (10%) e AOD (10,1%, p\u2009=\u20090,98), sem nenhum caso de embolia pulmonar em ambos os grupos. N\u00e3o houve diferen\u00e7a significativa entre os grupos AAS (1,4%) e AOD (1,5%) em rela\u00e7\u00e3o \u00e0s complica\u00e7\u00f5es da ferida (p\u2009=\u20090,95).<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003A tromboprofilaxia p\u00f3s-operat\u00f3ria apenas com AAS n\u00e3o foi associada a um maior risco de TEV p\u00f3s-operat\u00f3rio em compara\u00e7\u00e3o \u00e0 AOD ap\u00f3s ATJ. Considerando a ampla disponibilidade e custo-benef\u00edcio, o AAS pode ser uma alternativa promissora ao AOD para a profilaxia de TEV.<\/jats:p>","DOI":"10.1055\/s-0044-1785510","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T23:30:21Z","timestamp":1734823821000},"page":"e883-e887","source":"Crossref","is-referenced-by-count":0,"title":["Compara\u00e7\u00e3o de \u00e1cido acetilsalic\u00edlico e anticoagulante oral direto como tromboprofilaxia ap\u00f3s artroplastia total do joelho: Um estudo retrospectivo"],"prefix":"10.1055","volume":"59","author":[{"given":"Endrotomo","family":"Sumargono","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Ortop\u00e9dica, St. Carolus Hospital, Jakarta, Indon\u00e9sia"},{"name":"Faculdade de Medicina, Universitas Katolik Indonesia Atma Jaya, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Anastasia","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universitas Katolik Indonesia Atma Jaya, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard Christianto","family":"Singjie","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universitas Katolik Indonesia Atma Jaya, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifran","family":"Saleh","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Ortop\u00e9dica, St. Carolus Hospital, Jakarta, Indon\u00e9sia"},{"name":"Departamento de Cirurgia Ortop\u00e9dica, Faculdade de Medicina, Universitas Indonesia, Jakarta, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira Juliet","family":"Anestessia","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universitas Trisakti, Jakarta, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-8205","authenticated-orcid":false,"given":"Erica","family":"Kholinne","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Ortop\u00e9dica, St. Carolus Hospital, Jakarta, Indon\u00e9sia"},{"name":"Faculdade de Medicina, Universitas Trisakti, Jakarta, Indon\u00e9sia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"issue":"17","key":"ref1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1505467","article-title":"A randomized, controlled trial of total knee replacement","volume":"373","author":"S T Skou","year":"2015","journal-title":"N Engl J Med"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2106\/JBJS.17.01617","article-title":"Projected volume of primary total joint arthroplasty in the 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