{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:31:42Z","timestamp":1773297102437,"version":"3.50.1"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n            Objective and Background\u2003Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data.<\/jats:p><jats:p>\n            Methods\u2003Incidences of PE after CA of supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter (AFlu), and ventricular tachycardias (VT) in three German tertiary centers between 2005 and 2020 were determined and coded by the G-DRG (German Diagnosis Related Groups System) and OPS (German Operation and Procedure Classification) systems. An administrative search was performed with a consecutive case-based analysis.<\/jats:p><jats:p>\n            Results\u2003Overall, 47,344 ablations were analyzed (10,037 SVT; 28,048 AF; 6,252 AFlu; 3,007 VT). PE occurred in 14 (0.03%) predominantly female (n\u2009=\u20099; 64.3%) patients with a mean age of 55.3\u2009\u00b1\u200916.9 years, body mass index 26.2\u2009\u00b1\u20095.1\u2009kg\/m2, and left ventricular ejection fraction of 56\u2009\u00b1\u200913.6%. PE incidences were 0.05% (n\u2009=\u20095) for SVT, 0.02% (n\u2009=\u20095) for AF, and 0.13% (n\u2009=\u20094) for VT ablations. No patient suffered PE after AFlu ablation. Five patients (35.7%) with PE after CA had no prior indication for oral anticoagulation (OAC). Preprocedural international normalized ratio in PE patients was 1.2\u2009\u00b1\u20090.5. Most patients with PE following CA presented with symptoms the day after the procedure (n\u2009=\u20099) after intraprocedural heparin application of 12,943.2\u2009\u00b1\u20095,415.5\u2009IU. PE treatment included anticoagulation with either phenprocoumon (n\u2009=\u20095) or non-vitamin K-dependent OAC (n\u2009=\u20099). Two patients with PE died after VT\/AF ablation, respectively. The remaining patients were discharged without sequels.<\/jats:p><jats:p>\n            Conclusion\u2003Over a 15-year period, incidence of PE after ablation is low, particularly low in patients with ablation for AF\/AFlu. This is most likely due to stricter anticoagulation management in these patients compared with those receiving SVT\/VT ablation procedures and could argue for continuation of OAC prior to ablation. Optimizing periprocedural anticoagulation management should be subject of further prospective trials.<\/jats:p>","DOI":"10.1055\/s-0044-1785519","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T22:30:27Z","timestamp":1711924227000},"page":"861-869","source":"Crossref","is-referenced-by-count":3,"title":["In-Hospital Pulmonary Arterial Embolism after Catheter Ablation of Over 45,000 Cardiac Arrhythmias: Individualized Case Analysis of Multicentric Data"],"prefix":"10.1055","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-6283","authenticated-orcid":false,"given":"Florian","family":"Doldi","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Ge\u00dfler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, Asklepios Clinic St. Georg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, Asklepios Clinic St. Georg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-6693","authenticated-orcid":false,"given":"Ann-Kathrin","family":"Kahle","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Angiologie, Intensivmedizin, cNEP Research Consortium EVK, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Scherschel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Angiologie, Intensivmedizin, cNEP Research Consortium EVK, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Rath","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"K\u00f6be","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp Sebastian","family":"Lange","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Frommeyer","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kardiologie, Universit\u00e4res Herz- und Gef\u00e4\u00dfzentrum UKE Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Angiologie, Intensivmedizin, cNEP Research Consortium EVK, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, Asklepios Clinic St. Georg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, Asklepios Clinic St. Georg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department for Cardiology II: Electrophysiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/eurheartj\/ehz467","article-title":"2019 ESC Guidelines for the management of patients with supraventricular tachycardia: the Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)","volume":"41","author":"J Brugada","year":"2020","journal-title":"Eur Heart J"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/europace\/euac146","article-title":"In-hospital mortality and major complications related to radiofrequency catheter ablations of over 10 000 supraventricular arrhythmias from 2005 to 2020: individualized case analysis of multicentric administrative data","volume":"25","author":"F Doldi","year":"2023","journal-title":"Europace"},{"issue":"05","key":"ref3","first-page":"715","article-title":"Management of ventricular arrhythmias worldwide: comparison of the latest ESC, AHA\/ACC\/HRS, and CCS\/CHRS guidelines","volume":"9","author":"H K\u00f6nemann","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"euad091","DOI":"10.1093\/europace\/euad091","article-title":"Spotlight on the 2022 ESC guideline management of ventricular arrhythmias and prevention of sudden cardiac death: 10 novel key aspects","volume":"25","author":"H K\u00f6nemann","year":"2023","journal-title":"Europace"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1046\/j.1540-8167.2003.02180.x","article-title":"Endocardial 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Burstein","year":"2017","journal-title":"Chest"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"euad361","DOI":"10.1093\/europace\/euad361","article-title":"Major in-hospital complications after catheter ablation of cardiac arrhythmias: individual case analysis of 43 031 procedures","volume":"26","author":"L Eckardt","year":"2023","journal-title":"Europace"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jacep.2017.05.005","article-title":"Catheter ablation for cardiac arrhythmias: utilization and in-hospital complications, 2000 to 2013","volume":"3","author":"S M Hosseini","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.hrthm.2011.05.017","article-title":"Incidence and predictors of major complications from contemporary catheter ablation to treat cardiac arrhythmias","volume":"8","author":"M Bohnen","year":"2011","journal-title":"Heart Rhythm"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/CIRCEP.113.000768","article-title":"Complications of catheter ablation of atrial fibrillation: a systematic review","volume":"6","author":"A Gupta","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10840-020-00769-z","article-title":"Efficacy and complications of cavo-tricuspid isthmus-dependent atrial flutter ablation in patients with and without structural heart disease: results from the German Ablation Registry","volume":"61","author":"D G Dechering","year":"2021","journal-title":"J Interv Card Electrophysiol"},{"issue":"01","key":"ref28","first-page":"100","article-title":"Catheter ablation of ventricular arrhythmias and in-hospital mortality: insights from the German-wide Helios hospital network of 5052 cases","volume":"22","author":"S K\u00f6nig","year":"2020","journal-title":"Europace"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00392-021-01902-2","article-title":"Complications and mortality after catheter ablation of ventricular arrhythmias: risk in VT ablation (RIVA) score","volume":"111","author":"S Mathew","year":"2022","journal-title":"Clin Res Cardiol"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCEP.114.001530","article-title":"Complications of catheter ablation of ventricular tachycardia: a single-center experience","volume":"7","author":"P Peichl","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1007\/s00392-023-02223-2","article-title":"Predictors for major in-hospital complications after catheter ablation of ventricular arrhythmias: validation and modification of the Risk in Ventricular Ablation (RIVA) Score","volume":"112","author":"F Doldi","year":"2023","journal-title":"Clin Res Cardiol"},{"issue":"44","key":"ref32","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1093\/eurheartj\/ehy528","article-title":"In-hospital mortality of patients with atrial arrhythmias: insights from the German-wide Helios hospital network of 161\u2009502 patients and 34\u2009025 arrhythmia-related procedures","volume":"39","author":"S K\u00f6nig","year":"2018","journal-title":"Eur Heart J"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10840-018-0461-9","article-title":"Prevention of venous thrombosis after electrophysiology procedures: a survey of national practice","volume":"53","author":"B Burstein","year":"2018","journal-title":"J Interv Card Electrophysiol"},{"issue":"13","key":"ref34","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.0693","article-title":"Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the cabana randomized clinical trial","volume":"321","author":"D L Packer","year":"2019","journal-title":"JAMA"},{"issue":"26","key":"ref35","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1056\/NEJMoa065457","article-title":"Prophylactic catheter ablation for the prevention of defibrillator therapy","volume":"357","author":"V Y Reddy","year":"2007","journal-title":"N Engl J Med"},{"issue":"45","key":"ref36","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1093\/eurheartj\/ehy452","article-title":"Incidence of complications related to catheter ablation of atrial fibrillation and atrial flutter: a nationwide in-hospital analysis of administrative data for Germany in 2014","volume":"39","author":"G Steinbeck","year":"2018","journal-title":"Eur Heart J"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/europace\/euac236","article-title":"Patient selection, peri-procedural management, and ablation techniques for catheter ablation of atrial fibrillation: an EHRA survey","volume":"25","author":"K Iliodromitis","year":"2023","journal-title":"Europace"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/europace\/eux275","article-title":"2017\u2009HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary","volume":"20","author":"H Calkins","year":"2018","journal-title":"Europace"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/europace\/euab175","article-title":"Meta-analysis of controlled studies on minimally interrupted vs. continuous use of non-vitamin K antagonist oral anticoagulants in catheter ablation for atrial fibrillation","volume":"23","author":"S PG Van Vugt","year":"2021","journal-title":"Europace"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"P Kirchhof","year":"2016","journal-title":"Europace"},{"issue":"08","key":"ref41","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/europace\/euv190","article-title":"Antithrombotic management in patients undergoing electrophysiological procedures: a European Heart Rhythm Association (EHRA) position document endorsed by the ESC Working Group Thrombosis, Heart Rhythm Society (HRS), and Asia Pacific Heart Rhythm Society (APHRS)","volume":"17","author":"C Sticherling","year":"2015","journal-title":"Europace"},{"issue":"03","key":"ref42","first-page":"179","article-title":"Predisposing factors for atrial fibrillation in the 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