{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:41:46Z","timestamp":1785897706009,"version":"3.56.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Gallium-68 prostate-specific membrane antigen (68Ga-PSMA) imaging is valuable for staging because an accurate diagnosis, metastatic or nonmetastatic for prostate cancer patients, is required for deciding to treatment approaches and prognostic assessment. The aim of this study was primarily to distinguish between benign and metastatic adrenal gland lesions detected during 68Ga-PSMA positron emission tomography (PET)\/CT imaging, to evaluate the presence of factors predicting its development, and then to determine the life expectancy of patients with metastatic adrenal lesions.<\/jats:p><jats:p>\n          Materials and Methods\u2003We performed a database search for PET\/CT records generated from June 2016 to February 2021 for \u201cadrenal gland\u201d in report for patients who underwent 68Ga-PSMA examination with prostate cancer patients.<\/jats:p><jats:p>\n          Results\u2003Twenty-three patients (10 benign and 13 metastatic) were included in this study. The total prostate-specific antigen, adrenal gland size, adrenal gland density, and maximum standardized uptake (SUVmax) values are significantly different between groups (p\u2009&lt;\u20090.05). On receiver operating characteristic curve analysis, the SUVmax cutoff value\u2009&gt;\u20096.8 provided both sensitivity and specificity of 100%. However, with 29\u2009mm as the adrenal gland size cutoff and 21.2 as Hounsfield unit, the sensitivity and specificity were 56.2 and 92.3%, and 93.8 and 92.3%, respectively. The survival of the benign and metastatic groups was compared and a statistically significant difference was found (p\u2009=\u20090.006). The presence of pelvic lymph nodes was statistically negatively affected the surveillance between the groups.<\/jats:p><jats:p>\n          Conclusion\u2003The presence of atypical metastases such as adrenal gland is not insignificant in prostate cancer patients. Because of this degree of impact on patient management, accurate staging by imaging with 68Ga-PSMA should be an integral part of prostate cancer management.<\/jats:p>","DOI":"10.1055\/s-0044-1786012","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:55:30Z","timestamp":1713916530000},"page":"103-109","source":"Crossref","is-referenced-by-count":2,"title":["The Role of 68Ga PSMA Imaging in Evaluating Adrenal Lesions in Prostate Cancer Patients"],"prefix":"10.1055","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-1032","authenticated-orcid":false,"given":"Funda","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra \u00d6zdemir","family":"G\u00fcnay","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethi Emre","family":"Ustaba\u015f\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Trakya University, Edirne, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/cncr.21778","article-title":"Metastatic patterns in adenocarcinoma","volume":"106","author":"K R Hess","year":"2006","journal-title":"Cancer"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.eururo.2014.07.020","article-title":"Impact of the site of metastases on survival in patients with metastatic prostate cancer","volume":"68","author":"G Gandaglia","year":"2015","journal-title":"Eur Urol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1148\/rg.2018170108","article-title":"Prostate-specific membrane antigen PET: clinical utility in prostate cancer, normal patterns, pearls, and pitfalls","volume":"38","author":"M S Hofman","year":"2018","journal-title":"Radiographics"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.eururo.2019.01.049","article-title":"Gallium-68 prostate-specific membrane antigen positron emission tomography in advanced prostate cancer-updated diagnostic utility, sensitivity, specificity, and distribution of prostate-specific membrane antigen-avid lesions: a systematic review and meta-analysis","volume":"77","author":"M Perera","year":"2020","journal-title":"Eur Urol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.0300-0664.2001.01435.x","article-title":"Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital","volume":"56","author":"K Y Lam","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/pros.22742","article-title":"Distribution of metastatic sites in patients with prostate cancer: a population-based analysis","volume":"74","author":"G Gandaglia","year":"2014","journal-title":"Prostate"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2214\/AJR.11.7533","article-title":"Atypical metastases from prostate cancer: 10-year experience at a single institution","volume":"199","author":"A H Vinjamoori","year":"2012","journal-title":"AJR Am J Roentgenol"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.5858\/2008-132-931-MPOCRF","article-title":"Metastatic patterns of cancers: results from a large autopsy study","volume":"132","author":"G Disibio","year":"2008","journal-title":"Arch Pathol Lab Med"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/1097-0142(19860815)58:4<985::AID-CNCR2820580432>3.0.CO;2-I","article-title":"Metastatic behavior of prostate cancer. 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