{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:25:44Z","timestamp":1790306744745,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n            Background\u2003Continuous monitoring using implantable cardiac monitors (ICMs) results in atrial fibrillation (AF) detection rates of up to 30% in patients with cryptogenic stroke (CS). Although higher age is an independent risk factor for AF, there are no age-specific recommendations for the implantation of ICM.<\/jats:p><jats:p>\n            Objective\u2003The aim of this study was to analyze age-related AF rates in patients with CS and continuous rhythm monitoring, to determine the rates of oral anticoagulation (OAC) and recurrent cerebrovascular events (stroke or transient ischemic attack) in patients with ICM-detected AF, and to describe the temporal relationship of AF detection and recurrent cerebrovascular events.<\/jats:p><jats:p>\n            Methods\u2003In this observational study, patients with CS provided with ICMs were systematically followed. All patients underwent 72-hour electrocardiography monitoring, transcranial Doppler ultrasound, and transthoracic echocardiography prior to ICM insertion. Follow-up included a regular outpatient presentation every 3 months with medical history, physical examination, and interrogation of the ICM.<\/jats:p><jats:p>\n            Results\u2003One-hundred eighty-six patients (mean age: 65\u2009\u00b1\u200912 years, 54% female) were included in this analysis. AF was detected in 6, 27, 56, and 65% (p\u2009&lt;\u20090.001) of patients aged less than 60, 60 to 69, 70 to 79, and more than or equal to 80 years, respectively. All patients with AF under 60 years had an impaired left ventricular systolic function. OAC was initiated in 85% of the patients with AF. Recurrent cerebrovascular events occurred in 34 patients of whom 14 had a diagnosis of AF. In nine patients, AF was diagnosed before the occurrence of a recurrent cerebrovascular event.<\/jats:p><jats:p>\n            Conclusion\u2003AF prevalence increased with age and was absent in CS patients younger than 60 years and with preserved left ventricular ejection fraction. The temporal relationship of AF and recurrent cerebrovascular events was weak.<\/jats:p>","DOI":"10.1055\/s-0044-1786015","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T23:03:41Z","timestamp":1713395021000},"page":"e202-e208","source":"Crossref","is-referenced-by-count":4,"title":["Age-Dependent Detection of Atrial Fibrillation with Implantable Cardiac Monitors in Patients with Cryptogenic Stroke"],"prefix":"10.1055","volume":"08","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-2427","authenticated-orcid":false,"given":"Tobias","family":"Uhe","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kardiologie, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Keilitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Klinikum Altenburger Land, Altenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Berrouschot","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Klinikum Altenburger Land, Altenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Wachter","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kardiologie, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1474-4422(17)30002-9","article-title":"Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AFRANDOMISED): an open-label randomised controlled trial","volume":"16","author":"R Wachter","year":"2017","journal-title":"Lancet Neurol"},{"issue":"26","key":"ref2","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1056\/NEJMoa1313600","article-title":"Cryptogenic stroke and underlying atrial fibrillation","volume":"370","author":"T Sanna","year":"2014","journal-title":"N Engl J Med"},{"issue":"26","key":"ref3","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1311376","article-title":"Atrial fibrillation in patients with cryptogenic stroke","volume":"370","author":"D J Gladstone","year":"2014","journal-title":"N Engl J Med"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1001\/jama.1994.03510350050036","article-title":"Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study","volume":"271","author":"E J Benjamin","year":"1994","journal-title":"JAMA"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s00415-013-6935-x","article-title":"Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study","volume":"260","author":"R Wachter","year":"2013","journal-title":"J Neurol"},{"issue":"21","key":"ref6","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.113.007825","article-title":"Temporal relationship between subclinical atrial fibrillation and embolic events","volume":"129","author":"M Brambatti","year":"2014","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ahj.2017.04.007","article-title":"Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE-AF) randomized trial: design and rationale","volume":"190","author":"R A Bernstein","year":"2017","journal-title":"Am Heart J"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"G Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"ref9","volume-title":"Diagnostik akuter zerebrovaskul\u00e4rer Erkrankungen","author":"M G Hennerici"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"E von Elm","year":"2007","journal-title":"Lancet"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1001\/jama.2021.6128","article-title":"Effect of implantable vs prolonged external electrocardiographic monitoring on atrial fibrillation detection in patients with ischemic stroke: The PER DIEM randomized clinical trial","volume":"325","author":"B H Buck","year":"2021","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0140-6736(21)01698-6","article-title":"Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial","volume":"398","author":"J H Svendsen","year":"2021","journal-title":"Lancet"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/jamacardio.2017.3180","article-title":"Incidence of previously undiagnosed atrial fibrillation using insertable cardiac monitors in a high-risk population: the REVEAL AF study","volume":"2","author":"J A Reiffel","year":"2017","journal-title":"JAMA Cardiol"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(21)00067-3","article-title":"Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study","volume":"20","author":"K G Haeusler","year":"2021","journal-title":"Lancet Neurol"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1055\/a-1346-2899","article-title":"Atrial fibrillation in patients with embolic stroke of undetermined source during 3 years of prolonged monitoring with an implantable loop recorder","volume":"121","author":"A Kitsiou","year":"2021","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-0041-1726403","article-title":"Subclinical atrial fibrillation and the risk of recurrent ischemic stroke","volume":"121","author":"R Wachter","year":"2021","journal-title":"Thromb Haemost"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.hrthm.2011.04.022","article-title":"Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: a subgroup analysis of TRENDS","volume":"8","author":"E G Daoud","year":"2011","journal-title":"Heart Rhythm"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/17474930221094682","article-title":"Should we adjudicate outcomes in stroke trials? A systematic review","volume":"18","author":"P J Godolphin","year":"2023","journal-title":"Int J Stroke"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ahj.2023.06.016","article-title":"Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism-the Find-AF 2 study-rationale and design","volume":"265","author":"T Uhe","year":"2023","journal-title":"Am Heart J"}],"container-title":["TH Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1786015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T10:48:21Z","timestamp":1730803701000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1786015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":19,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1786015","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}